Assay system
First Claim
Patent Images
1. An assay cartridge comprising detachable base and cap members;
- at least one well being disposed in said base member and a membrane-tipped pipette positionable in at least one said well, wherein said pipette is closed at one end by a liquid permeable membrane, said membrane being planar and angled relative to an axis of the pipette, and wherein said well comprises a base or side wall through which radiation from the membrane may pass when the pipette is in the well;
said cap member being arranged to carry said membrane tipped pipette and wherein said well is sealed at its upper end by a frangible seal wherein said cap member is provided with a cutter arranged to pierce said seal.
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Abstract
An assay apparatus comprising: i) an assay cartridge (52, 53) comprising at least one well (57-62) and a pipette (50) positionable in at least one said well; ii) a holder arranged to received said cartridge; iii) drive means operable to position said pipette in selected wells of said cartridge; iv) a gas pressure applicator couplable to said pipette whereby to cause liquid flow through said membrane; and v) a radiation detector operable to detect radiation from a well of said cartridge of said cartridge or from said pipette.
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Citations
20 Claims
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1. An assay cartridge comprising detachable base and cap members;
- at least one well being disposed in said base member and a membrane-tipped pipette positionable in at least one said well, wherein said pipette is closed at one end by a liquid permeable membrane, said membrane being planar and angled relative to an axis of the pipette, and wherein said well comprises a base or side wall through which radiation from the membrane may pass when the pipette is in the well;
said cap member being arranged to carry said membrane tipped pipette and wherein said well is sealed at its upper end by a frangible seal wherein said cap member is provided with a cutter arranged to pierce said seal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
- at least one well being disposed in said base member and a membrane-tipped pipette positionable in at least one said well, wherein said pipette is closed at one end by a liquid permeable membrane, said membrane being planar and angled relative to an axis of the pipette, and wherein said well comprises a base or side wall through which radiation from the membrane may pass when the pipette is in the well;
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14. An assay device comprising:
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a) a cartridge holder, capable of receiving an assay cartridge comprising (i) at least one well and (ii) a membrane-tipped pipette positionable in at least one said well, wherein said pipette is closed at one end by a liquid permeable membrane, said membrane being planar and angled relative to an axis of the pipette, and wherein said well comprises a base or side wall through which radiation from the membrane may pass when the pipette is in said well; b) drive means operable to position the membrane-tipped pipette of a said cartridge in at least one selected well of said cartridge; c) a gas pressure applicator couplable to the membrane-tipped pipette of a said cartridge whereby to cause liquid flow therethrough; and d) a radiation detector operable to detect radiation from the membrane of a membrane-tipped pipette of a said cartridge through a base or side wall of a well of the said cartridge when the pipette is in the well. - View Dependent Claims (15, 16, 17)
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18. An assay apparatus comprising:
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a) a cartridge holder; b) a removable assay cartridge comprising (i) at least one well and (ii) a membrane-tipped pipette positionable in at least one said well, wherein said pipette is closed at one end by a liquid permeable membrane, said membrane being planar and angled relative to an axis of the pipette, and wherein said well comprises a base or side wall through which radiation from the membrane may pass when the pipette is in said well; c) drive means operable to position the membrane-tipped pipette of said cartridge in at least one selected well of said cartridge; d) a gas pressure applicator couplable to the membrane-tipped pipette of said cartridge whereby to cause liquid flow therethrough; and e) a radiation detector operable to detect radiation from the membrane of the membrane-tipped pipette of said cartridge through a base or side wall of said well when the pipette is in the well. - View Dependent Claims (19)
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20. An assay cartridge comprising detachable base and cap members;
- at least one well being disposed in said base member and a membrane-tipped pipette positionable in at least one said well, wherein said pipette is closed at one end by a liquid permeable membrane, said membrane being planar and angled relative to an axis of the pipette, and wherein said well comprises a base or side wall through which radiation from the membrane may pass when the pipette is in the well;
said cap member being arranged to carry said membrane tipped pipette and wherein said base member comprises an absorbent wiper arranged to wipe the outside of a capillary-tipped pipette inserted therein.
- at least one well being disposed in said base member and a membrane-tipped pipette positionable in at least one said well, wherein said pipette is closed at one end by a liquid permeable membrane, said membrane being planar and angled relative to an axis of the pipette, and wherein said well comprises a base or side wall through which radiation from the membrane may pass when the pipette is in the well;
Specification