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Human antibodies to the human glucagon receptor and methods of use thereof

  • US 8,545,847 B2
  • Filed: 11/22/2011
  • Issued: 10/01/2013
  • Est. Priority Date: 11/23/2010
  • Status: Active Grant
First Claim
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1. An isolated human antibody or antigen-binding fragment thereof that specifically binds human glucagon receptor (hGCGR), wherein the antibody comprises the complementarity determining regions (CDRs) of a heavy chain variable region (HCVR), wherein the HCVR has an amino acid sequence as set forth in SEQ ID NO:

  • 86; and

    the CDRs of a light chain variable region (LCVR), wherein the LCVR has an amino acid sequence as set forth in SEQ ID NO;

    88.

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