Anti-CD79B antibodies and immunoconjugates and methods of use
First Claim
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1. An immunoconjugate comprising an anti-CD79b antibody comprising:
- (i) an HVR-L1 sequence of KASQSVDYEGDSFLN (SEQ ID NO;
194)(ii) an HVR-L2 sequence of AASNLES (SEQ ID NO;
195)(iii) an HVR-L3 sequence of QQSNEDPLT (SEQ ID NO;
196)(iv) an HVR-H1 sequence of GYTFSSYWIE (SEQ ID NO;
202)(v) an HVR-H2 sequence of GEILPGGGDTNYNEIFKG (SEQ ID NO;
203), and(vi) an HVR-H3 sequence of TRRVPIRLDY (SEQ ID NO;
204),wherein said antibody is covalently attached to a cytotoxic agent.
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Abstract
The present invention is directed to compositions of matter comprising immunoconjugates comprising an anti-CD79b antibody comprising: (i) an HVR-L1 sequence of KASQSVDYEGDSFLN (SEQ ID NO: 194), (ii) an HVR-L2 sequence of AASNLES (SEQ ID NO: 195), (iii) an HVR-L3 sequence of QQSNEDPLT (SEQ ID NO: 196), (iv) an HVR-H1 sequence of GYTFSSYWIE (SEQ ID NO: 202), (v) an HVR-H2 sequence of GEILPGGGDTNYNEIFKG (SEQ ID NO: 203), and (vi) an HVR-H3 sequence of TRRVPIRLDY (SEQ ID NO: 204) and to methods of using those compositions of matter for the treatment of hematopoietic tumor in mammals.
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8 Claims
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1. An immunoconjugate comprising an anti-CD79b antibody comprising:
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(i) an HVR-L1 sequence of KASQSVDYEGDSFLN (SEQ ID NO;
194)(ii) an HVR-L2 sequence of AASNLES (SEQ ID NO;
195)(iii) an HVR-L3 sequence of QQSNEDPLT (SEQ ID NO;
196)(iv) an HVR-H1 sequence of GYTFSSYWIE (SEQ ID NO;
202)(v) an HVR-H2 sequence of GEILPGGGDTNYNEIFKG (SEQ ID NO;
203), and(vi) an HVR-H3 sequence of TRRVPIRLDY (SEQ ID NO;
204),wherein said antibody is covalently attached to a cytotoxic agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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Specification