Compositions and methods for surface abrasion with frozen particles

• US 8,545,855 B2
• Filed: 02/26/2009
• Issued: 10/01/2013
• Est. Priority Date: 10/31/2008
• Status: Active Grant

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Boyden, Edward S., Cook, Daniel B., Hyde, Roderick A., Leuthardt, Eric C., Myhrvold, Nathan P., Sweeney, Elizabeth A., Wood, Lowell L. Jr.
• Primary Examiner(s): Hartley, Michael G
• Assistant Examiner(s): Rider, Lance W
• Application Number:
  US12/380,550
• Publication Number:
  US 20100114013A1
• Time in Patent Office: 1,678 Days
• Field of Search: None
• US Class Current: 424/400
• CPC Class Codes: A61K 9/1682 Processes

Abstract

Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

Claims

1. A method for abrasion of at least one biological tissue surface of a subject, comprising:

delivering at least one frozen particle composition to at least one surface of at least one biological tissue of a subject in a manner sufficient to abrade the at least one surface of the at least one biological tissue;

wherein the at least one frozen particle composition includes one or more frozen particles coated in nitroglycerine;

wherein delivering includes propelling at a predetermined pressure; and

wherein the one or more frozen particles have at least one major dimension of approximately one micrometer or less.

2. The method of claim 1, wherein the at least one composition is propelled to desired location on or in the at least one biological tissue.

3. The method of claim 1, further comprising extracting or collecting material from the at least one abraded surface of at least one biological tissue.

4. The method of claim 1, wherein the at least one biological tissue is located in at least one of in situ, in vitro, in vivo, in utero, in planta, or ex vivo.

5. The method of claim 4, wherein the at least one biological tissue is located in at least one tissue or organ related to transplantation.

6. The method of claim 5, wherein the at least one tissue or organ related to transplantation includes at least one donor or recipient tissue or organ.

7. The method of claim 4, wherein the at least one biological tissue is ingested by at least one subject.

8. The method of claim 1, wherein the at least one biological tissue includes at least one cell mass.

9. The method of claim 1, further including delivering to the at least one biological tissue at least one of a polymer, biopolymer, nanoparticle, or detection material.

10. The method of claim 9, wherein the detection material includes at least one electronic identification device.

11. The method of claim 9, wherein the detection material includes at least one radioactive element.

12. The method of claim 9, wherein the detection material includes at least one colorimetric substance.

13. The method of claim 9, wherein the detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic contrast agent, or other magnetic particle.

14. The method of claim 1, wherein the subject includes at least one invertebrate or vertebrate animal.