Porous calcium phosphate bone material
First Claim
1. A self-setting, porous calcium phosphate composition comprising a calcium phosphate, an effervescent agent comprising carbonate and bicarbonate that reacts upon hydration of said composition to produce carbon dioxide as a gaseous component, and a biocompatible cohesiveness agent, wherein release of said gaseous component from said composition produces at least 5% porosity in a hardened material formed after said hydration of said composition, and wherein, after hardening, said hardened material has a compressive strength of 1 MPa or greater.
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Abstract
Porous calcium phosphate implant compositions that approximate the chemical composition of natural bone mineral are provided. In addition to calcium phosphate, the compositions include an effervescent agent to promote the formation of interconnected pores and a cohesiveness agent to maintain the shape and hardness of the hardened composition. When introduced at an implant site, the calcium phosphate compositions are remodeled into bone. Methods for using the calcium phosphate compositions, e.g., to repair or replace bone, are also provided.
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Citations
29 Claims
- 1. A self-setting, porous calcium phosphate composition comprising a calcium phosphate, an effervescent agent comprising carbonate and bicarbonate that reacts upon hydration of said composition to produce carbon dioxide as a gaseous component, and a biocompatible cohesiveness agent, wherein release of said gaseous component from said composition produces at least 5% porosity in a hardened material formed after said hydration of said composition, and wherein, after hardening, said hardened material has a compressive strength of 1 MPa or greater.
Specification