Composition for use as an assay reagent
First Claim
1. A composition for use as an assay reagent, the composition comprising:
- a solid support comprising a member of a signal producing system and a coating of a synthetic copolymer wherein the synthetic consists of(i) a first copolymerized monomer comprising a pendant moiety wherein the pendant moiety has the formula;
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C(O)-A-(CH2)n-Gwherein A is NR1 wherein R1 is H or alkyl of from 1 to 6 carbon atoms and n is 1 to 10 and wherein G is CHO;
CH(OR8)2 wherein R8 is alkyl of from 1 to 6 carbon atoms;
or a member of a specific binding pair; and
(ii) a second copolymerized monomer comprising a pendant moiety wherein the pendant moiety has the formula;
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Abstract
A composition for use as an assay reagent comprises a solid support comprising a member of a signal producing system and a coating of a synthetic copolymer. The synthetic copolymer comprises a first polymerized monomer comprising a pendant moiety comprising a reactive functionality or a derivative of a reactive functionality and a second polymerized monomer comprising a pendant moiety comprising at least 1 carbon atoms and at least 2 heteroatoms. In some embodiments the copolymer comprises a polyethylenic backbone comprising the pendant moiety comprising a reactive functionality or a derivative of a reactive functionality and the pendant moiety comprising at least 1 carbon atom and at least 2 heteroatoms.
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Citations
13 Claims
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1. A composition for use as an assay reagent, the composition comprising:
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a solid support comprising a member of a signal producing system and a coating of a synthetic copolymer wherein the synthetic consists of (i) a first copolymerized monomer comprising a pendant moiety wherein the pendant moiety has the formula;
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C(O)-A-(CH2)n-Gwherein A is NR1 wherein R1 is H or alkyl of from 1 to 6 carbon atoms and n is 1 to 10 and wherein G is CHO;
CH(OR8)2 wherein R8 is alkyl of from 1 to 6 carbon atoms;
or a member of a specific binding pair; and(ii) a second copolymerized monomer comprising a pendant moiety wherein the pendant moiety has the formula; - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method of determining in a sample the presence and/or amount of an analyte, the method comprising:
(a) providing in combination in a medium; (i) the sample, and (ii) a composition comprising; a particle comprising; (A) a member of a signal producing system, (B) a member of the specific binding pair that binds to the analyte or to a second sbp member to form a complex related to the presence of the analyte and (C) a coating of a copolymer of the formula; - View Dependent Claims (11, 12, 13)
Specification