Self-assembling hydrogels based on dicephalic peptide amphiphiles

• US 8,546,338 B2
• Filed: 12/08/2010
• Issued: 10/01/2013
• Est. Priority Date: 12/08/2010
• Status: Active Grant

• Current Assignee: Johnson & Johnson Consumer Inc. (Johnson & Johnson)
• Original Assignee: Johnson & Johnson Consumer Companies Incorporated (Johnson & Johnson)
• Inventors: Donners, Jackie J., Nathan, Aruna
• Primary Examiner(s): Tsang, Cecilia J
• Assistant Examiner(s): NIEBAUER, RONALD T
• Application Number:
  US12/962,775
• Publication Number:
  US 20120148674A1
• Time in Patent Office: 1,028 Days
• Field of Search: None
• US Class Current: 514/21.6
• CPC Class Codes: A61K 47/42 Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein oligopeptides having up to five amino acids A61K47/183; polyamino acids A61K47/34
• CPC Class Codes: C07K 7/02 Linear peptides containing at least one abnormal peptide link
• CPC Class Codes: C07K 7/06 having 5 to 11 amino acids
• CPC Class Codes: C07K 7/08 having 12 to 20 amino acids gastrins C07K14/595; somatostatins C07K14/655; melanotropins C07K14/68

Abstract

We have disclosed dicephalic amphiphiles having peptide sequences as the head groups. We have also disclosed self-assembly hydrogels prepared from the dicephalic peptide amphiphiles. These hydrogels are useful for the encapsulation and delivery of bioactives to a patient.

Claims

1. A dicephalic peptide amphiphile comprising the formula:

2. The dicephalic peptide amphiphile of claim 1 wherein n is in the range of 6 to about 22.

3. The dicephalic peptide amphiphile of claim 2 wherein n is in the range of about 12 to about 18.

4. A hydrogel comprising the dicephalic peptide amphiphile of claim 1.