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Multi-armed, monofunctional, and hydrolytically stable derivatives of poly(ethylene glycol) and related polymers for modification of surfaces and molecules

  • US 8,546,493 B2
  • Filed: 12/14/2012
  • Issued: 10/01/2013
  • Est. Priority Date: 01/10/1995
  • Status: Expired due to Fees
First Claim
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1. A method for preparing a branched, monofunctional, water-soluble polymer, the method comprising:

  • (i) reacting a monomethoxypoly(ethylene glycol)polymer comprising a single reactive moiety, W, and having the structure mPEG-W, where W is the single reactive moiety, with a linker molecule comprising from 1 to 10 carbon atoms and having the structure X—

    C(Y)(R)—

    Z,where X and Y each independently comprise reactive groups that can react with W to form hydrolytically stable linkage fragments P and Q, respectively,Z is a moiety that (a) comprises a single ionizable reactive site that is capable of reacting with ion exchange chromatography media, and (b) is not reactive with either X or Y, andR is H, methyl or another alkyl group,under conditions effective to provide an impure branched monofunctional, water-soluble polymer having the structure;

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