Carbocyclic alpha-L-bicyclic nucleic acid analogs
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Abstract
The present invention provides novel carbocyclic α-L-bicyclic nucleosides and oligomeric compounds comprising at least one of these carbocyclic α-L-bicyclic nucleosides. The carbocyclic α-L-bicyclic nucleosides are useful for enhancing one or more properties of the oligomeric compounds they are incorporated into including nuclease resistance.
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Citations
32 Claims
- 1. A bicyclic nucleoside having Formula I:
- 15. An oligomeric compound comprising at least one bicyclic nucleoside having Formula III:
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