Nasal delivery
First Claim
1. A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising:
- a nosepiece unit including a nosepiece for fitting to a nostril of a subject and a nozzle through which substance is in use delivered, preferably substantially axially to a longitudinal axis of the nosepiece, to the respective nasal cavity, wherein at least a tip element of the nosepiece has a pre-defined shape and configuration having an elongate lateral section which has a longer dimension in a first, sagittal direction than a second direction orthogonal to the sagittal direction, such that, when the nosepiece is inserted in the nasal cavity of the subject, the longer dimension of the tip element of the nosepiece acts to engage lower and upper surfaces of the nasal cavity and expand the same in the sagittal plane, preferably at least the tip element of the nosepiece comprises one of a substantially rigid structure, a semi-rigid structure or a flexible structure or the nosepiece comprises a flexible nosepiece member which defines at least the tip element of the nosepiece and a supporting member which acts structurally to support the nosepiece member, preferably the supporting member is configured such as to render the nosepiece member substantially rigid in the vertical, sagittal plane, but otherwise render flexibility to the nosepiece member, preferably such as to allow for bending in the horizontal plane and torsional flexing about the longitudinal axis of the nosepiece, and preferably the supporting member comprises an elongate plate which extends along an axial length of the nosepiece member in the sagittal plane; and
a delivery unit for delivering substance through the nozzle of the nosepiece.
5 Assignments
0 Petitions
Accused Products
Abstract
A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a nosepiece unit (20, 24) including a nosepiece (17) for fitting to a nostril of a subject and a nozzle (45) through which substance is in use delivered, preferably substantially axially to a longitudinal axis of the nosepiece, to the respective nasal cavity, wherein at least a tip element of the nosepiece has, at least in one configuration, an elongate lateral section which has a longer dimension in a first, sagittal direction than a second direction orthogonal to the sagittal direction, such that, when the nosepiece is inserted in the nasal cavity of the subject, the longer dimension of the nosepiece acts to engage lower and upper surfaces of the nasal cavity, preferably at the nasal valve, and expand the same in the sagittal plane; and a delivery unit (43, 49, 51) for delivering substance through the nozzle of the nosepiece.
117 Citations
28 Claims
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1. A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising:
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a nosepiece unit including a nosepiece for fitting to a nostril of a subject and a nozzle through which substance is in use delivered, preferably substantially axially to a longitudinal axis of the nosepiece, to the respective nasal cavity, wherein at least a tip element of the nosepiece has a pre-defined shape and configuration having an elongate lateral section which has a longer dimension in a first, sagittal direction than a second direction orthogonal to the sagittal direction, such that, when the nosepiece is inserted in the nasal cavity of the subject, the longer dimension of the tip element of the nosepiece acts to engage lower and upper surfaces of the nasal cavity and expand the same in the sagittal plane, preferably at least the tip element of the nosepiece comprises one of a substantially rigid structure, a semi-rigid structure or a flexible structure or the nosepiece comprises a flexible nosepiece member which defines at least the tip element of the nosepiece and a supporting member which acts structurally to support the nosepiece member, preferably the supporting member is configured such as to render the nosepiece member substantially rigid in the vertical, sagittal plane, but otherwise render flexibility to the nosepiece member, preferably such as to allow for bending in the horizontal plane and torsional flexing about the longitudinal axis of the nosepiece, and preferably the supporting member comprises an elongate plate which extends along an axial length of the nosepiece member in the sagittal plane; and a delivery unit for delivering substance through the nozzle of the nosepiece. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising:
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a nosepiece unit including a nosepiece for fitting to a nostril of a subject and a nozzle through which substance is in use delivered, preferably substantially axially to a longitudinal axis of the nosepiece, to the respective nasal cavity, wherein at least a tip element of the nosepiece is expandable, such as to have an elongate lateral section when expanded, the elongate lateral section having a longer dimension in a first, sagittal direction than a second direction orthogonal to the sagittal direction, such that, when the nosepiece is inserted in the nasal cavity of the subject, the longer dimension of the tip element of the nosepiece acts to engage lower and upper surfaces of the nasal cavity and expand the same in the sagittal plane, preferably the nosepiece unit includes pivoting arms which are manually operated to provide for expansion of the nosepiece, preferably the tip element of the nosepiece comprises a tubular section of a flexible material which expands in the vertical, sagittal direction when compressed in the horizontal direction, and preferably the tip element of the nosepiece includes supporting elements which extend from inner surfaces of the lateral sections of the tip element of the nosepiece, such as to prevent compression of the lateral sections of the tip element of the nosepiece beyond a predeterminable separation; and a delivery unit for delivering substance through the nozzle of the nosepiece.
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9. A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising:
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a nosepiece unit including a nosepiece for fitting to a nostril of a subject and a nozzle which provides for the delivery of a single jet or a plurality of jets which define a jet spray, preferably substantially axially to a longitudinal axis of the nosepiece, to the respective nasal cavity, wherein at least a tip element of the nosepiece has, at least in one configuration, an elongate lateral section which has a longer dimension in a first, sagittal direction than a second direction orthogonal to the sagittal direction, such that, when the nosepiece is inserted in the nasal cavity of the subject, the longer dimension of the tip element of the nosepiece acts to engage lower and upper surfaces of the nasal cavity and expand the same in the sagittal plane, preferably the jet spray has an asymmetric profile, with the jet spray having a greater spray angle in the vertical, sagittal direction than in the horizontal direction, preferably the spray angle in the vertical, sagittal direction is greater than about 35°
, preferably greater than about 40°
, preferably greater than about 45° and
preferably greater than about 50°
, and preferably the spray angle in the horizontal direction is not more than about 35°
, preferably not more than about 30°
, preferably not more than about 25°
, preferably not more than about 20°
, preferably not more than about 15°
, preferably not more than about 10° and
preferably approaching 0°
; anda delivery unit for delivering substance through the nozzle of the nosepiece. - View Dependent Claims (10)
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11. A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising:
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a nosepiece unit including a nosepiece for fitting to a nostril of a subject and a nozzle which provides for the delivery of an aerosol spray, preferably substantially axially to a longitudinal axis of the nosepiece, to the respective nasal cavity, wherein at least a tip element of the nosepiece has, at least in one configuration, an elongate lateral section which has a longer dimension in a first, sagittal direction than a second direction orthogonal to the sagittal direction, such that, when the nosepiece is inserted in the nasal cavity of the subject, the longer dimension of the tip element of the nosepiece acts to engage lower and upper surfaces of the nasal cavity and expand the same in the sagittal plane, preferably the aerosol spray has an asymmetric profile, with the aerosol spray having a greater spray angle in the vertical, sagittal direction than in the horizontal direction, preferably the spray angle in the vertical, sagittal direction is greater than about 35°
, preferably greater than about 40°
, preferably greater than about 45° and
preferably greater than about 50°
, and preferably the spray angle in the horizontal direction is not more than about 35°
, preferably not more than about 30°
, preferably not more than about 25°
, preferably not more than about 20° and
preferably not more than about 15′
; anda delivery unit for delivering substance through the nozzle of the nosepiece. - View Dependent Claims (12)
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13. A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising:
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a mouthpiece unit through which the subject in use exhales to cause closure of the oropharyngeal velum of the subject; a nosepiece unit including a nosepiece for fitting to a nostril of a subject and a nozzle through which substance is in use delivered, preferably substantially axially to a longitudinal axis of the nosepiece, to the respective nasal cavity, wherein at least a tip element of the nosepiece has, at least in one configuration, an elongate lateral section which has a longer dimension in a first, sagittal direction than a second direction orthogonal to the sagittal direction, such that, when the nosepiece is inserted in the nasal cavity of the subject, the longer dimension of the tip element of the nosepiece acts to engage lower and upper surfaces of the nasal cavity and expand the same in the sagittal plane; and a delivery unit for delivering substance through the nozzle of the nosepiece; and preferably further comprising one of; a flow channel fluidly connecting the nosepiece and the mouthpiece unit, whereby exhaled air from an exhalation breath is delivered through the nosepiece;
ora flow channel fluidly connected to the nosepiece through which a gas flow, separate to an exhaled air flow from an exhalation breath of the subject, is in use delivered to the nosepiece; and a gas supply unit for supplying a gas flow to the flow channel.
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14. A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising:
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a nosepiece unit including a nosepiece for fitting to a nostril of a subject and a nozzle which provides for the delivery a jet spray, preferably substantially axially to a longitudinal axis of the nosepiece, to the respective nasal cavity, wherein the nozzle is configured to deliver substance with an asymmetric profile, such that the profile has a greater angle in a first, sagittal direction than a second direction orthogonal to the sagittal direction, preferably defined by a plurality of jets, preferably the jet spray has a greater spray angle in the vertical, sagittal direction than in the horizontal direction, preferably the spray angle in the vertical, sagittal direction is greater than about 35°
, preferably greater than about 40°
, preferably greater than about 45° and
preferably greater than about 50°
, and preferably the spray angle in the horizontal direction is not more than about 35°
, preferably not more than about 30°
, preferably not more than about 25°
, preferably not more than about 20°
, preferably not more than about 15°
, preferably not more than about 10° and
preferably approaching 0°
; anda delivery unit for delivering substance through the nozzle of the nosepiece. - View Dependent Claims (15)
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16. A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising:
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a nosepiece unit including a nosepiece for fitting to a nostril of a subject and a nozzle which provides for the delivery of an aerosol spray, preferably substantially axially to a longitudinal axis of the nosepiece, to the respective nasal cavity, wherein the nozzle is configured to deliver substance with an asymmetric profile, such that the profile has a greater angle in a first, sagittal direction than a second direction orthogonal to the sagittal direction, preferably the aerosol spray has a greater spray angle in the vertical, sagittal direction than in the horizontal direction, preferably the spray angle in the vertical, sagittal direction is greater than about 35°
, preferably greater than about 40°
, preferably greater than about 45° and
preferably greater than about 50°
, and preferably the spray angle in the horizontal direction is not more than about 35°
, preferably not more than about 30°
, preferably not more than about 25°
, preferably not more than about 20° and
preferably not more than about 15°
; anda delivery unit for delivering substance through the nozzle of the nosepiece. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising:
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a nosepiece unit including a nosepiece for fitting to a nostril of a subject and a nozzle through which substance is in use delivered to the respective nasal cavity, wherein the nozzle provides for the delivery of a plurality of jets which define a jet spray, wherein the jet spray has an asymmetric profile, such that the profile has a greater angle in a first direction than a second direction orthogonal to the first direction, preferably the spray angle in the first direction is greater than about 35°
, preferably greater than about 40°
, preferably greater than about 45° and
preferably greater than about 50°
, and preferably the spray angle in the second direction is not more than about 35°
, preferably not more than about 30°
, preferably not more than about 25°
, preferably not more than about 20°
, preferably not more than about 15°
, preferably not more than about 10° and
preferably approaching 0°
; anda delivery unit for delivering substance through the nozzle of the nosepiece. - View Dependent Claims (28)
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Specification