Respiration monitoring for heart failure using implantable device

• US 8,551,010 B2
• Filed: 07/19/2012
• Issued: 10/08/2013
• Est. Priority Date: 08/08/2006
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Pu, Yachuan, Lee, Kent, Kwok, Jonathan, Ni, Quan
• Primary Examiner(s): Kahelin, Michael
• Assistant Examiner(s): TOTH, KAREN E
• Application Number:
  US13/553,098
• Publication Number:
  US 20120283527A1
• Time in Patent Office: 446 Days
• Field of Search: 600429-543
• US Class Current: 600/534
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/4818 Sleep apnoea
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance

Abstract

An implantable respiration monitor can be used to detect disordered breathing or periodic breathing events that can be categorized, such as according to one or more of sleep, exercise, and resting awake states. The categorized frequency of such events can be compared to independently specifiable thresholds, such as to trigger an alert or responsive therapy, or to display one or more trends. The information can also be combined with detection of one or more other congestive heart failure (CHF) symptoms to generate a CHF status indicator or to trigger an alarm or responsive therapy or to display one or more trends. The alert can notify the patient or a caregiver, such as via remote monitoring. The sleep state information can be further categorized according to central sleep apnea (CSA) or obstructive sleep apnea (OSA) events.

Claims

1. A method comprising:

detecting a sleep indication in a subject, the sleep indication providing an indication or inference of whether the subject is asleep or awake;

detecting an exercise indication in the subject, the exercise indication providing an indication or inference of whether the subject is active or at rest; and

monitoring respiration of the subject using a respiration monitor, including;

detecting disordered breathing in the subject;

receiving the sleep indication and the exercise indication; and

computing a sleep disordered breathing indication (DBsleep) indicative of disordered breathing occurring when the sleep indication indicates or infers that the subject is asleep, an exercise disordered breathing indication (DBexercise) indicative of disordered breathing occurring when the exercise indication indicates or infers that the subject is active, and a resting awake disordered breathing indication (DBrest) indicative of disordered breathing occurring when the sleep indication indicates or infers that the subject is awake and the exercise indication indicates or infers that the subject is at rest, wherein the monitoring respiration includes computing a combined disordered breathing metric, DBtotal, according to DBtotal=A·

DBsleep+B·

DBexercise+C·

DBrest, wherein A, B, and C are independently specifiable scaling values.

2. The method of claim 1, comprising generating an alert in response to an abnormal value of at least one of:

the sleep disordered breathing indication, the exercise disordered breathing indication, and the resting awake disordered breathing indication.

3. The method of claim 2, comprising automatically delivering a therapy in response to the alert.

4. The method of claim 1, comprising:

monitoring an auxiliary indication of congestive heart failure of the subject; and

generating an alert in response to an abnormal value of the auxiliary indication of congestive heart failure and an abnormal value of at least one of;

the sleep disordered breathing indication, the exercise disordered breathing indication, and the resting awake disordered breathing indication.

5. The method of claim 4, wherein monitoring the auxiliary indication of congestive heart failure includes monitoring at least one of a pulmonary fluid accumulation, a pulmonary artery pressure, a heart sound, a heart rate variability, a patient weight, and a patient activity level.

6. The method of claim 4, comprising automatically delivering a therapy in response to the alert.

7. The method of claim 1, comprising displaying information about at least one of a sleep disordered breathing indication, an exercise disordered breathing indication, and a resting awake disordered breathing indication.

8. The method of claim 1, comprising:

detecting one or more apnea events;

classifying the one or more apnea events as obstructive sleep apnea (OSA) or central sleep apnea (CSA); and

determining the sleep disordered breathing indication using information about the classification of the one or more apnea events as OSA or CSA.

9. The method of claim 8, comprising determining a first sleep disordered breathing indication using only CSA events.

10. The method of claim 9, comprising determining a second sleep disordered breathing indication using only OSA events.

11. A method comprising:

detecting a sleep indication in a subject, the sleep indication providing an indication or inference of whether the subject is asleep or awake;

detecting an exercise indication in the subject, the exercise indication providing an indication or inference of whether the subject is active or at rest;

detecting disordered breathing in the subject using a respiration monitor, including;

receiving the sleep indication and the exercise indication; and

computing at least two of;

a sleep disordered breathing indication indicative of disordered breathing occurring when the sleep indication indicates or infers that the subject is asleep, an exercise disordered breathing indication indicative of disordered breathing occurring when the exercise indication indicates or infers that the subject is active, and a resting awake disordered breathing indication indicative of disordered breathing occurring when the sleep indication indicates or infers that the subject is awake and the exercise indication indicates or infers that the subject is at rest; and

generating an alert in response to at least an abnormal value or a specified increase in at least two of;

the sleep disordered breathing indication, the exercise disordered breathing indication, and the resting awake disordered breathing indication.

12. The method of claim 11, comprising automatically initiating or adjusting therapy in response to the alert.

13. The method of claim 11, comprising:

detecting or measuring an auxiliary congestive heart failure (CHF) indication; and

generating the alert in response to the auxiliary CHF indication and an abnormal value or a specified increase of at least two of;

the sleep disordered breathing indication, the exercise disordered breathing indication, and the resting awake disordered breathing indication.

14. The method of claim 13, wherein detecting or measuring the auxiliary CHF indication includes detecting or measuring a pulmonary fluid accumulation, wherein the auxiliary CHF indication includes an indication of an abnormally high level of pulmonary fluid.

15. The method of claim 13, wherein detecting or measuring the auxiliary CHF indication includes detecting or measuring at least one of a pulmonary artery pressure, a heart sound, a heart rate variability, a patient weight, and a patient activity.

16. The method of claim 13, comprising automatically initiating or adjusting therapy in response to the alert.

17. The method of claim 11, wherein detecting disordered breathing includes:

detecting a respiration signal from the subject;

detecting an envelope of the respiration signal; and

detecting a variation in the envelope representing disordered breathing.

18. The method of claim 11, comprising displaying information about at least one of a sleep disordered breathing indication, an exercise disordered breathing indication, and a resting awake disordered breathing indication.

19. The method of claim 18, wherein displaying the information includes displaying a trend over time of at least one of a sleep disordered breathing indication, an exercise disordered breathing indication, and a resting awake disordered breathing indication.

20. The method of claim 11, comprising distinguishing between obstructive sleep apnea (OSA) and central sleep apnea (CSA) using an apnea classifier;

wherein the sleep disordered breathing indication uses information from the apnea classifier to determine the sleep disordered breathing indication.