Methods and systems for endovascularly clipping and repairing lumen and tissue defects

• US 8,551,132 B2
• Filed: 04/19/2007
• Issued: 10/08/2013
• Est. Priority Date: 10/19/2005
• Status: Active Grant

• Current Assignee: Pulsar Vascular, Inc. (Johnson & Johnson)
• Original Assignee: Pulsar Vascular, Inc. (Johnson & Johnson)
• Inventors: Eskridge, Joseph, Clarke, Gilbert, Pease, Matthew, Mast, Gregory Martin, Muskivitch, John Conrad
• Primary Examiner(s): Jackson, Gary
• Assistant Examiner(s): YABUT, DIANE D
• Application Number:
  US11/737,700
• Publication Number:
  US 20070191884A1
• Time in Patent Office: 2,364 Days
• Field of Search: 606/200, 606/213, 606/191, 623/1.11
• US Class Current: 606/191
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12109 in a blood vessel
• CPC Class Codes: A61B 17/12113 within an aneurysm
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/122 Clamps or clips , e.g. for the umbilical cord for the vas deferens A61F6/206
• CPC Class Codes: A61B 2017/00867 shape memory effect for prostheses A61F2210/0014
• CPC Class Codes: A61B 2017/1205 Introduction devices
• CPC Class Codes: A61B 2017/12054 Details concerning the detachment of the occluding device from the introduction device
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61F 2/06 Blood vessels

Abstract

An implantable closure structure is delivered using minimally invasive techniques, and inhibits the migration of liquid and particulate matter from inside a physiological cavity or opening, such as an aneurysm or a septal defect, as well as inhibiting the flow of liquid and particulate matter, such as from an associated blood vessel or chamber, into the physiological cavity or opening. The device has a closure structure that covers the neck or opening of a cavity and has one or more anchoring structures for supporting and retaining the closure structure in place across the cavity or opening.

Claims

1. An implantable device for repairing an opening or cavity in a target tissue defect, the implantable device being adjustable from a delivery condition in which it assumes a generally small diameter configuration to a deployed condition in which it assumes a larger diameter configuration, the implantable device comprising:

a closure structure sized to substantially cover the opening or cavity when the device is in the deployed condition, wherein the closure structure comprises a concave structure configured to extend away from the target tissue defect in said deployed condition; and

a first anchoring structure extending in a first direction from a first portion of the closure structure, and a second anchoring structure extending from a second, different portion of the closure structure in a generally opposite second direction from the first direction when the device is in the deployed condition,

wherein the first and second anchoring structures form generally closed loop atraumatic structures having a diameter larger than that of the closure structure when the device is in the deployed condition, and

wherein the first and second anchoring structures are configured to extend toward the target tissue defect in a direction generally opposite to a concavity of the closure structure.

2. The implantable device of claim 1, further comprising at least one radiopaque marker associated with at least one of the first and second anchoring structures.

3. The implantable device of claim 2, further comprising at least one radiopaque marker associated with each of the first and second anchoring structures.

4. The implantable device of claim 2 wherein the radiopaque marker comprises a composition selected from the group consisting of:

tantalum, gold, silver, barium, platinum, tungsten and combinations thereof.

5. The implantable device of claim 1, further comprising a radiopaque marker positioned intermediate the first and second anchoring structures.

6. The implantable device of claim 1, further comprising a radiopaque marker associated with the closure structure.

7. The implantable device of claim 1 wherein the closure structure has a substantially continuous occlusive surface area.

8. The implantable device of claim 1 wherein the closure structure has radial flexibility configured to mimic the structure and movement of the target tissue.

9. The implantable device of claim 1 wherein the closure structure comprises a material selected from the group consisting of:

silicone materials;

rubber materials;

woven and non-woven fabrics;

fluoropolymer compositions;

polymeric materials, polyurethane materials, metallic materials and combinations thereof.

10. The implantable device of claim 1 wherein the closure structure comprises a thin film shape memory alloy.

11. The implantable device of claim 1 wherein the closure structure has a porous surface structure provided over at least a portion of its surface area.

12. The implantable device of claim 1 wherein the closure structure comprises a material that is permeable to liquids but substantially excludes cells from traversing the closure structure.

13. The implantable device of claim 1, further comprising a reinforcing structure having framework structure in proximity to the perimeter of the closure structure.

14. The implantable device of claim 1 wherein the first and second anchoring structures have a material density over their surface area that is less than the density of the closure structure over its surface area.

15. The implantable device of claim 1 wherein the first and second anchoring structures comprise a biocompatible shape memory alloy material.

16. The implantable device of claim 1 wherein the first and second anchoring structures have substantially the same configurations and/or dimensions.

17. The implantable device of claim 1 wherein the first and second anchoring structures have different configurations and/or dimensions.

18. The implantable device of claim 1 wherein the first and second anchoring structures are substantially aligned with one another in a deployed condition.

19. The implantable device of claim 1 wherein the first and/or second anchoring structures have a mesh-like or porous configuration.

20. The implantable device of claim 1 wherein the implantable device further comprises one or more of the following:

agents that promote cellular ingrowth and attachment at the target site;

hydrophilic agents;

hydrophobic agents;

bonding agents;

friction-reducing agents;

radiopaque agents;

antibiotic agents;

thrombogenic agents;

anti-thrombogenic agents;

therapeutic agents;

hydrogel compositions;

anti-inflammatory agents;

anti-restenosis agents;

radioactive agents; and

combinations thereof.

21. An implantable device for repairing an opening or cavity in a target tissue defect, the implantable device being adjustable from a first, generally small diameter delivery configuration to a second, larger diameter deployed configuration, the implantable device comprising:

a closure structure sized to substantially cover the opening or cavity when the device is in the deployed configuration, wherein the closure structure comprises a curved structure having a convex surface facing the target tissue defect and a concave surface opposite the convex surface and facing away from the target tissue defect; and

a first anchoring structure and a second anchoring structure extending directly from the convex surface of the closure structure and configured to extend generally toward the target tissue defect when the implantable device is in the deployed configuration,

wherein the first and second anchoring structures comprise closed loop structures having diameters larger than that of the closure structure when the implantable device is in the deployed configuration, and

wherein the first anchoring structure extends from a first portion of the closure structure in a first direction and the second anchoring structure extends from a second, different portion of the closure structure in a second direction generally opposite to the first direction.

22. The implantable device of claim 21 wherein the first anchoring structure and the second anchoring structure have generally identical configurations.

23. The implantable device of claim 21 wherein the first anchoring structure and the second anchoring structure have different configurations.

24. The implantable device of claim 21 wherein the first anchoring structure and the second anchoring structure are sized to fit within the target tissue defect when the implantable device is in the deployed configuration.

25. The implantable device of claim 21 wherein:

the first anchoring structure extends in the first direction from a periphery of the closure structure; and

the second anchoring structure extends in the second direction from the periphery of the closure structure.

26. The implantable device of claim 21 wherein:

the first anchoring structure extends in the first direction from a first portion of the closure structure at least proximate to a periphery of the closure structure; and

the second anchoring structure extends in the second direction from a second portion of the closure structure at least proximate to the periphery of the closure structure.