Method and apparatus for producing autologous clotting components
First Claim
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1. A method of separating a clotting component from a whole blood sample in a container having a mixing assembly and a member, comprising:
- collecting a whole blood sample;
introducing the whole blood sample into a single chamber of the container;
manipulating the mixing assembly to mix the whole blood sample with the member to at least one of activate a portion of the whole blood sample or to withdraw a selected volume of water from the whole blood sample, wherein the mixing assembly includes a central member with radially extending agitation members;
moving a piston within the single chamber of the container to compress the mixture of the whole blood sample and the member towards a first end of the container, wherein the compression with the piston at least assists in moving a selected component of the whole blood sample between a proximal surface of the piston and a second end of the container away from the first end; and
withdrawing a volume of a fluid including concentrated clotting components from the single chamber of the container after mixing the whole blood sample with the member.
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Abstract
A method and apparatus for obtaining various components of a multi-component material. Generally, a component of a whole blood sample may be concentrated from a patient and re-introduced to the same patient. For example, a clotting component, such as thrombin, from a whole blood sample may be extracted and concentrated in an apparatus and collection to be reapplied or reintroduced into a patient.
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Citations
30 Claims
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1. A method of separating a clotting component from a whole blood sample in a container having a mixing assembly and a member, comprising:
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collecting a whole blood sample; introducing the whole blood sample into a single chamber of the container; manipulating the mixing assembly to mix the whole blood sample with the member to at least one of activate a portion of the whole blood sample or to withdraw a selected volume of water from the whole blood sample, wherein the mixing assembly includes a central member with radially extending agitation members; moving a piston within the single chamber of the container to compress the mixture of the whole blood sample and the member towards a first end of the container, wherein the compression with the piston at least assists in moving a selected component of the whole blood sample between a proximal surface of the piston and a second end of the container away from the first end; and withdrawing a volume of a fluid including concentrated clotting components from the single chamber of the container after mixing the whole blood sample with the member. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method of separating a clotting component from a whole blood sample in a container having a mixing assembly and a member, comprising:
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collecting a whole blood sample; introducing the whole blood sample into a volume of the container; manipulating the mixing assembly to mix the whole blood sample with the member within the volume to at least one of activate a portion of the whole blood sample or to withdraw a selected volume of water from the whole blood sample, wherein the mixing assembly includes a plurality of radially extending agitation members; centrifuging the container to move a piston within the volume to at least assist in separation of a fluid including concentrated clotting components; and withdrawing a volume of the fluid including concentrated clotting components from the volume of the container after mixing the whole blood sample with the member. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26)
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27. A method of separating a clotting component from a whole blood sample in a container having a mixing assembly and a member, comprising:
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collecting a whole blood sample; introducing the whole blood sample into a single chamber defined by a wall of the container through a bore defined by a mixing assembly, wherein the single chamber of the container further contains the mixing assembly and the member, wherein the mixing assembly includes a plurality of radially extending agitation members; manipulating the mixing assembly to mix the whole blood sample with the member within the single chamber to at least one of activate a portion of the whole blood sample or to absorb a selected volume of water from the whole blood sample; and withdrawing a volume of a fluid including concentrated clotting components from the single chamber of the container after mixing the whole blood sample with the member. - View Dependent Claims (28, 29, 30)
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Specification