Compositions and methods for therapeutic delivery with frozen particles

• US 8,551,505 B2
• Filed: 02/26/2009
• Issued: 10/08/2013
• Est. Priority Date: 10/31/2008
• Status: Expired due to Fees

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Boyden, Edward S., Hyde, Roderick A., Leuthardt, Eric C., Myhrvold, Nathan P., Sweeney, Elizabeth A., Wood, Lowell L. Jr.
• Primary Examiner(s): Hartley, Michael G
• Assistant Examiner(s): Rider, Lance W
• Application Number:
  US12/380,568
• Publication Number:
  US 20100112093A1
• Time in Patent Office: 1,685 Days
• Field of Search: None
• US Class Current: 424/400
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/10 Sulfides; Sulfoxides; Sulfones
• CPC Class Codes: A61K 31/337 having four-membered rings, e.g. taxol
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047
• CPC Class Codes: A61K 31/7088 Compounds having three or more nucleosides or nucleotides
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 39/00 Medicinal preparations containing antigens or antibodies materials for immunoassay G01N33/53
• CPC Class Codes: A61K 41/0004 Homeopathy; Vitalisation; Resonance; Dynamisation, e.g. esoteric applications; Oxygenation of blood
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 49/1818 particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
• CPC Class Codes: A61K 51/12 characterised by a special physical form, e.g. emulsion, microcapsules, liposomes , characterized by a special physical form, e.g. emulsions, dispersions, microcapsules liposomes A61K51/1234
• CPC Class Codes: A61K 51/1244 microparticles or nanoparticles, e.g. polymeric nanoparticles
• CPC Class Codes: A61K 9/0021 Intradermal administration, e.g. through microneedle arrays, needleless injectors mechanical aspects A61M
• CPC Class Codes: A61K 9/08 Solutions composition of solutions A61K47/00
• CPC Class Codes: A61K 9/1611 Inorganic compounds
• CPC Class Codes: A61K 9/1641 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
• CPC Class Codes: A61K 9/1664 Compounds of unknown constitution, e.g. material from plants or animals oils, fats, waxes, shellac A61K9/1617
• CPC Class Codes: A61K 9/1688 resulting in pure drug agglomerate optionally containing up to 5% of excipient
• CPC Class Codes: A61K 9/19 lyophilised , i.e. freeze-dried, solutions or dispersions lyophilised products with subsequent particle size reduction A61K9/14; granules or pellets made by lyphilisation A61K9/1682; solid oral dosage forms made by lyophilisation A61K9/2095; lyophilisation additives A61K47/00
• CPC Class Codes: F26B 5/06 : the process involving freezing

Abstract

Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

Claims

1. A method of providing at least one therapeutic agent to at least one biological tissue of a subject, comprising:

delivering at least one therapeutic composition including at least one anti-inflammatory agent to at least one biological tissue, wherein the at least one therapeutic composition includes one or more frozen particles including at least one frozen gas of helium, neon, xenon, krypton, or bromine, and

wherein delivering includes delivering by propulsion at a predetermined pressure.

2. The method of claim 1, wherein the at least one therapeutic composition is propelled to a desired location of the at least one biological tissue.

3. The method of claim 1, wherein delivering at least one therapeutic composition includes accelerating the therapeutic composition toward at least one biological tissue.

4. The method of claim 3, wherein the at least one therapeutic composition is accelerated to a predetermined velocity for delivery of the at least one therapeutic composition to a desired location of the at least one biological tissue.

5. The method of claim 1, wherein delivering at least one therapeutic composition to at least one biological tissue includes propelling a plurality of therapeutic compositions toward the at least one biological tissue.

6. The method of claim 1, wherein delivering the at least one therapeutic composition occurs prior to, during, or subsequent to surgery.

7. The method of claim 1, wherein the at least one biological tissue is located in at least one of in situ, in vitro, in vivo, in utero, in planta, or ex vivo.

8. The method of claim 1, wherein the at least one biological tissue is transplanted or implanted into at least one subject.

9. The method of claim 7, wherein the at least one biological tissue is ingested by at least one subject.

10. The method of claim 7, wherein the at least one biological tissue includes at least one biological tissue from at least one donor or recipient.

11. The method of claim 7, wherein the at least one biological tissue includes at least one cell mass.

12. The method of claim 11, wherein the at least one cell mass includes at least one benign or malignant tumor.

13. The method of claim 1, further including delivering to the at least one biological tissue at least one of a polymer, biopolymer, nanoparticle, or detection material.

14. The method of claim 13, wherein the detection material includes at least one electronic identification device.

15. The method of claim 14, wherein the at least one electronic identification device includes at least one radio frequency identification device.

16. The method of claim 13, wherein the detection material includes at least one radioactive element.

17. The method of claim 13, wherein the detection material includes at least one colorimetric substance.

18. The method of claim 13, wherein the detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic contrast agent, or other magnetic particle.

19. The method of claim 1, wherein the subject includes at least one invertebrate or vertebrate animal.

20. The method of claim 1, wherein the subject includes at least one human.

21. The method of claim 19, wherein the subject includes at least one of livestock, pet, undomesticated herd animal, wild animal, or a product animal.

22. The method of claim 1, wherein the at least one therapeutic composition further includes one or more reinforcement agents.

23. The method of claim 1, wherein the at least one therapeutic composition further includes one or more explosive materials.

24. A method of providing at least one therapeutic agent to at least one biological tissue, comprising:

delivering at least one therapeutic composition to at least one biological tissue of a subject;

wherein the at least one therapeutic composition includes one or more frozen particles including at least one frozen gas of helium, neon, xenon, krypton, bromine; and

includes

paclitaxel; and

wherein the delivering includes delivering by propulsion at a predetermined pressure.

25. The method of claim 24, wherein the at least one therapeutic composition further includes one or more reinforcement agents.

26. The method of claim 24, wherein the at least one therapeutic composition further includes one or more explosive materials.