Compositions and methods for administering compartmentalized frozen particles

• US 8,551,506 B2
• Filed: 03/27/2009
• Issued: 10/08/2013
• Est. Priority Date: 10/31/2008
• Status: Active Grant

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Boyden, Edward S., Cook, Daniel B., Hyde, Roderick A., Leuthardt, Eric C., Myhrvold, Nathan P., Sweeney, Elizabeth A., Wood, Lowell L. Jr.
• Primary Examiner(s): Hartley, Michael G
• Assistant Examiner(s): Rider, Lance W
• Application Number:
  US12/383,851
• Publication Number:
  US 20100111849A1
• Time in Patent Office: 1,656 Days
• Field of Search: None
• US Class Current: 424/400
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/337 having four-membered rings, e.g. taxol
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047
• CPC Class Codes: A61K 31/7088 Compounds having three or more nucleosides or nucleotides
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 39/00 Medicinal preparations containing antigens or antibodies materials for immunoassay G01N33/53
• CPC Class Codes: A61K 41/0004 Homeopathy; Vitalisation; Resonance; Dynamisation, e.g. esoteric applications; Oxygenation of blood
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/12 Aerosols; Foams A61K9/0043, A61K9/0056, A61K9/006, A61K9/0073 take precedence; spray-films A61K9/7015
• CPC Class Codes: A61K 9/1611 Inorganic compounds
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: B33Y 80/00 Products made by additive manufacturing

Abstract

Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

Claims

1. A frozen particle composition, comprising:

a frozen citrate solution particle defining at least one cavity containing at least one liposome;

the at least one liposome containing at least one agent of cyanoacrylate, isocyanate, chitin, polyacrylic acid, poly (L-lactic acid), polyglycolide, polylactic acid, polyether, polyol, polyvinylpyrrolidone, pyroxylin, polymethacrylate-isobutene-monoisopropylmaleate, polylactic-co-glycolic-acid, carboxymethylcellulose, or methacrylate; and

wherein the frozen citrate solution particle is a frozen solution of sodium citrate in water, and wherein the frozen citrate solution particle is coated in one or more of collagen, fibrin, Factor XIII, Factor XII, thrombin, fibrinogen, hyaluronate, or glycosaminoglycan; and

is approximately one micrometer or less, approximately one nanometer or less, or any size value therebetween.

2. The frozen particle composition of claim 1, wherein at least one cavity is configured to physically or chemically separate the at least one agent from at least one other cavity of the frozen particle.

3. The frozen particle composition of claim 1, wherein at least one cavity is configured to physically or chemically separate from at least one other cavity of the frozen particle during administration.

4. The frozen particle composition of claim 1, wherein the at least one cavity is an inner core cavity of at least one frozen particle.

5. The frozen particle composition of claim 1, wherein the at least one cavity includes an inner core cavity and wherein the at least one agent is at least one of a liquid or gas.

6. The frozen particle composition of claim 1, wherein the at least one cavity has a higher concentration of the at least one agent than any other cavity.

7. The frozen particle composition of claim 6, wherein the at least one cavity includes a graduated concentration of the at least one agent.

8. The frozen particle composition of claim 1, wherein the at least one cavity includes varying levels of the at least one agent.

9. The frozen particle composition of claim 1, wherein the at least one agent is fractionated.

10. The frozen particle composition of claim 1, wherein the at least one cavity includes one or more layers of at least one agent.

11. The frozen particle composition of claim 1, further including two or more cavities, each containing at least one different agent.

12. The frozen particle composition of claim 1, wherein the at least one agent includes one or more of a pro-drug or precursor compound.

13. The frozen particle composition of claim 1, wherein the at least one agent includes one or more time-release or extended-release formulations.

14. The frozen particle composition of claim 1, wherein the at least one agent includes an activatable agent.

15. The frozen particle composition of claim 1, further a plurality of frozen particles that are approximately uniform in size, shape, weight, or density.

16. The frozen particle composition of claim 1, further including at least one pharmaceutically-acceptable carrier or excipient.

17. The frozen particle composition of claim 1, further including at least one of a nanoparticle, detection material, sensor, micro-syringe, or circuit.

18. The frozen particle composition of claim 17, wherein the detection material is intermixed with the at least one frozen particle composition.

19. The frozen particle composition of claim 17, wherein the detection material is located in the at least one frozen particle composition.

20. The frozen particle composition of claim 17, wherein the detection material is located in at least one cavity of at least one frozen particle composition.

21. The frozen particle composition of claim 17, wherein the detection material includes at least one electronic identification device.

22. The frozen particle composition of claim 21, wherein the at least one electronic identification device includes at least one radio frequency identification device.

23. The frozen particle composition of claim 17, wherein the detection material includes at least one radioactive element.

24. The frozen particle composition of claim 17, wherein the at least one radioactive element includes one or more of ³²P, ³⁵S, ¹³C, ¹³¹I, ¹⁹¹Ir, ¹⁹²Ir, ¹⁹³Ir, or ³H.

25. The frozen particle composition of claim 17, wherein the detection material includes at least one luminescent, colorimetric or odorous substance.

26. The frozen particle composition of claim 25, wherein the at least one colorimetric substance includes one or more of an inorganic, organic, biological, natural, artificial, or synthetic substance.

27. The frozen particle composition of claim 17, wherein the at least one detection material includes one or more of a dye, pigment, luminescent substance, fluorescent substance, or phosphorescent substance.

28. The frozen particle composition of claim 17, wherein the detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic contrast agent, or other magnetic particle.

29. The frozen particle composition of claim 1, wherein the at least one agent includes at least one nontoxic, biocompatible, bioresorbable, or biodegradable agent.