Localized delivery of cardiac inotropic agents
First Claim
Patent Images
1. A method of delivering a positive cardiac inotropic agent to the heart of a human subject, comprising:
- providing a delivery vehicle which is in the form of an adherent patch which comprises at least one positive inotropic agent and a barrier that is non-permeable to the positive inotropic agent, the barrier being effective to allow release of the positive inotropic agent toward the myocardium and to minimize release into the pericardial fluid;
adhering the delivery vehicle onto an outer surface of the heart away from the sinoatrial node of a subject in need of treatment; and
releasing a therapeutically effective amount of the positive inotropic agent in a controlled manner from the delivery vehicle directly to the heart to increase the force of myocardial contraction.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention provides novel methods for the localized delivery of inotropic agents to the heart, including specific regions of the heart, such as the ventricles, for example in a subject undergoing cardiothoracic surgery, with the aim of supporting the myocardial contractile function of the heart.
-
Citations
16 Claims
-
1. A method of delivering a positive cardiac inotropic agent to the heart of a human subject, comprising:
-
providing a delivery vehicle which is in the form of an adherent patch which comprises at least one positive inotropic agent and a barrier that is non-permeable to the positive inotropic agent, the barrier being effective to allow release of the positive inotropic agent toward the myocardium and to minimize release into the pericardial fluid; adhering the delivery vehicle onto an outer surface of the heart away from the sinoatrial node of a subject in need of treatment; and releasing a therapeutically effective amount of the positive inotropic agent in a controlled manner from the delivery vehicle directly to the heart to increase the force of myocardial contraction. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
-
Specification