Immunostimulatory oligonucleotides

• US 8,552,165 B2
• Filed: 12/08/2009
• Issued: 10/08/2013
• Est. Priority Date: 12/09/2008
• Status: Active Grant

• Current Assignee: Heather Davis, Risini Weeratna
• Original Assignee: Heather Davis, Risini Weeratna
• Inventors: Weeratna, Risini, Davis, Heather
• Primary Examiner(s): Minnifield, Nita M
• Application Number:
  US12/632,911
• Publication Number:
  US 20100143400A1
• Time in Patent Office: 1,400 Days
• Field of Search: None
• US Class Current: 536/23.1
• CPC Class Codes: A61K 2039/55561 CpG containing adjuvants; Oligonucleotide containing adjuvants
• CPC Class Codes: A61K 39/12 Viral antigens
• CPC Class Codes: A61K 39/145 Orthomyxoviridae, e.g. influenza virus
• CPC Class Codes: A61K 39/292 Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
• CPC Class Codes: A61K 39/39 characterised by the immunostimulating additives, e.g. chemical adjuvants
• CPC Class Codes: C12N 2730/10134 Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
• CPC Class Codes: C12N 2760/16134 Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention relates to immunostimulatory oligonucleotides and methods of using immunostimulatory oligonucleotides to induce an antigen-specific immune response. The invention further relates to a vaccine that comprises an immunostimulatory oligonucleotide and an antigen, and comprises a pharmaceutically acceptable carrier. The immunostimulatory oligonucleotides of the invention, in some embodiments, include one or more modified linkage(s).

Claims

1. An immunostimulatory oligonucleotide comprising the nucleotide sequence

2. The immunostimulatory oligonucleotide of claim 1, wherein the oligonucleotide comprises one or more modified linkages.

3. The immunostimulatory oligonucleotide of claim 2, wherein the oligonucleotide comprises one or more phosphorothioate linkages.

4. The immunostimulatory oligonucleotide of claim 1, wherein the oligonucleotide comprises at least one lipophilic substituted nucleotide analog and a pyrimidine-purine dinucleotide.