Method and apparatus for neural stimulation with respiratory feedback

• US 8,554,323 B2
• Filed: 01/31/2012
• Issued: 10/08/2013
• Est. Priority Date: 08/30/2006
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Haefner, Paul A., James, Kristofer J., Lee, Kent, Libbus, Imad, Caparso, Anthony V., Kwok, Jonathan, Pu, Yachuan
• Primary Examiner(s): DIETRICH, JOSEPH M
• Application Number:
  US13/363,198
• Publication Number:
  US 20120130446A1
• Time in Patent Office: 616 Days
• Field of Search: 607/2, 607/42, 600/529
• US Class Current: 607/42
• CPC Class Codes: A61B 5/08 Detecting, measuring or recording devices for evaluating the respiratory organs A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/4035 Evaluating the autonomic nervous system
• CPC Class Codes: A61B 5/4818 Sleep apnoea
• CPC Class Codes: A61N 1/3601 of respiratory organs
• CPC Class Codes: A61N 1/36053 adapted for vagal stimulation A61N1/36114 takes precedence
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362

Abstract

A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system synchronizes the delivery of the neural stimulation pulses to the respiratory cycles using a respiratory fiducial point in the respiratory signal and a delay interval. In another embodiment, the neural stimulation system detects a respiratory disorder and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected respiratory disorder.

Claims

1. A neural stimulation system, comprising:

a stimulation output circuit configured to deliver neural stimulation pulses;

a respiratory signal input configured to receive a respiratory signal indicative of respiratory cycles and respiratory parameters;

a synchronization module coupled to the stimulation output circuit and the respiratory signal input, the synchronization module including;

a peak detector coupled to the respiratory signal input, the peak detector configured to detect peaks of the respiratory signal; and

a delay timer coupled to the peak detector, the delay timer configured to time a delay interval starting with each of the detected peaks of the respiratory signal; and

a stimulation delivery controller coupled to the delay timer and the stimulation output circuit, the stimulation delivery controller configured to cause the stimulation output circuit to deliver a burst of the neural stimulation pulses when the delay interval expires.

2. The system of claim 1, wherein the synchronization module comprises a delay generator configured to adjust the delay interval using the respiratory signal.

3. The system of claim 2, wherein the delay generator is configured to calculate the delay interval as a function of one or more parameters of the respiratory parameters.

4. The system of claim 1, further comprising:

an implantable medical device including the stimulation output circuit, the respiratory signal input, the synchronization module, and the stimulation delivery controller;

an implantable respiratory sensor configured to sense a physiologic signal; and

a sensor processing circuit configured to produce the respiratory signal using the physiologic signal.

5. The system of claim 4, wherein the implantable respiratory sensor comprises an implantable impedance sensor configured to sense a transthoracic impedance.

6. The system of claim 4, wherein the implantable respiratory sensor comprises an implantable pulmonary artery pressure (PAP) sensor.

7. The system of claim 1, further comprising:

a respiratory disorder detector coupled to the respiratory signal input, the respiratory disorder detector configured to detect a respiratory disorder using the respiratory signal; and

a stimulation switch coupled to the respiratory disorder detector and the stimulation delivery controller, the stimulation switch configured to adjust the delivery of the neural stimulation pulses in response to the detection of the respiratory disorder.

8. The system of claim 7, wherein the respiratory disorder detector is configured to detect abnormal values in one or more parameters of the respiratory parameters.

9. The system of claim 7, wherein the respiratory disorder detector is configured to detect a respiratory disorder induced by the delivery of the neural stimulation pulses.

10. The system of claim 7, wherein the stimulation switch is configured to stop executing a first stimulation algorithm and start executing a second stimulation algorithm in response to the detection of the respiratory disorder.

11. A method for neural stimulation, the method comprising:

receiving a respiratory signal indicative of respiratory parameters;

detecting peaks of the respiratory signal;

starting delay intervals with selected peaks of the detected peaks; and

delivering a burst of neural stimulation pulses of the neural stimulation when each of the delay intervals expires.

12. The method of claim 11, further comprising programming the delay interval to a time interval between approximately 0 and 5 seconds.

13. The method of claim 11, further comprising adjusting the delay interval using the respiratory signal.

14. The method of claim 13, wherein adjusting the delay interval using the respiratory signal comprises:

detecting a respiratory rate from the respiratory signal; and

calculating the delay interval as a function of the respiratory rate.

15. The method of claim 11, wherein receiving the respiratory signal comprises receiving a transthoracic impedance signal.

16. The method of claim 11, wherein receiving the respiratory signal comprises receiving a pulmonary artery pressure (PAP) signal.

17. The method of claim 11, further comprising:

detecting a respiratory disorder using the respiratory signal; and

adjusting delivery of the neural stimulation in response to the detection of the respiratory disorder.

18. The method of claim 17, wherein detecting the respiratory disorder detector comprises detecting abnormal values in one or more parameters of the respiratory parameters.

19. The method of claim 17, wherein detecting the respiratory disorder detector comprises detecting a respiratory disorder induced by the delivery of the neural stimulation.

20. The method of claim 17, wherein adjusting delivery of the neural stimulation in response to the detection of the respiratory disorder comprises stopping execution of a first stimulation algorithm and starting execution of a second stimulation algorithm in response to the detection of the respiratory disorder.