Nasal delivery device
First Claim
1. A device for delivering a substance to the nasal airway of a subject, comprising:
- a flow resistor; and
a delivery unit for delivering a substance in a gas flow to a nostril of the subject, wherein the delivery unit comprises a nosepiece shaped and sized for insertion into a nostril of the subject, a delivery channel fluidly connected to the nosepiece and configured to receive the substance to be delivered to the nostril, the nosepiece comprising an outlet through which a substance may be delivered into the nasal airway of the subject and a sealing member configured to seal the one nostril of the subject to the outlet, the sealing member including a frusto-conical portion and having a first, distal end and a second, proximal end and being enlarged towards the proximal end to cause an anterior region of the nasal cavity into which the nosepiece is inserted to be enlarged, and a dispensing unit driven by an exhalation air flow of the subject so as to supply a metered dose of substance from the dispensing unit into the delivery channel;
wherein the device is configured to create a positive pressure differential between the oral cavity of the subject and the nasal airway of the subject when the subject exhales against the flow resistor, thereby indirectly achieving closure of the oropharyngeal velum of the subject, and the device is configured to deliver a substance entrained in a gas flow having a flow rate in the nasal airway of at least 20 liters per minute.
5 Assignments
0 Petitions
Accused Products
Abstract
A delivery device (20, 22) for and a method of delivering a substance to the nasal airway (1) of a subject, in particular the posterior region of the nasal airway, the delivery device comprising: a closure unit for causing the closure of the oropharyngeal velum of the subject; and a delivery unit for delivering a gas flow entraining a substance to one of the nostrils of the subject at such a driving pressure as to flow around the posterior margin of the nasal septum and out of the other nostril of the subject, wherein the delivery unit comprises a nosepiece (30, 40, 58, 82, 102, 132) which includes an outlet through which the gas flow is in use delivered to the one nostril and a sealing member for sealing the one nostril to the outlet such as in use to prevent the escape of the gas flow through the one nostril.
131 Citations
11 Claims
-
1. A device for delivering a substance to the nasal airway of a subject, comprising:
-
a flow resistor; and a delivery unit for delivering a substance in a gas flow to a nostril of the subject, wherein the delivery unit comprises a nosepiece shaped and sized for insertion into a nostril of the subject, a delivery channel fluidly connected to the nosepiece and configured to receive the substance to be delivered to the nostril, the nosepiece comprising an outlet through which a substance may be delivered into the nasal airway of the subject and a sealing member configured to seal the one nostril of the subject to the outlet, the sealing member including a frusto-conical portion and having a first, distal end and a second, proximal end and being enlarged towards the proximal end to cause an anterior region of the nasal cavity into which the nosepiece is inserted to be enlarged, and a dispensing unit driven by an exhalation air flow of the subject so as to supply a metered dose of substance from the dispensing unit into the delivery channel; wherein the device is configured to create a positive pressure differential between the oral cavity of the subject and the nasal airway of the subject when the subject exhales against the flow resistor, thereby indirectly achieving closure of the oropharyngeal velum of the subject, and the device is configured to deliver a substance entrained in a gas flow having a flow rate in the nasal airway of at least 20 liters per minute. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
-
Specification