Apparatus and method for determining a physiologic parameter of a patient applying fourier transformation

• US 8,556,818 B2
• Filed: 07/23/2007
• Issued: 10/15/2013
• Est. Priority Date: 08/03/2006
• Status: Active Grant

• Current Assignee: PULSION Medical Systems SE (Getinge AB)
• Original Assignee: PULSION Medical Systems SE (Getinge AB)
• Inventors: Joeken, Stephan
• Primary Examiner(s): Mallari, Patricia
• Assistant Examiner(s): MESSERSMITH, ERIC J
• Application Number:
  US11/880,633
• Publication Number:
  US 20080033306A1
• Time in Patent Office: 2,276 Days
• Field of Search: 600/300, 600481-507
• US Class Current: 600/484
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/7257 using Fourier transforms

Abstract

The apparatus comprises a pressure sensor providing readings of a blood pressure of the patient and storage means for storing the readings as a pressure curve over time. Blood pressure is measured. The frequency difference between heart rate and breathing rate is used to separate the respiratory effect from the heart activity. In particular, the Fourier transform of the blood pressure and the spectral density are used to determine the contribution of each frequency. The respiratory and cardiac power spectra are determined. The ratio between both powers is calculated as the quotient of the integrals over the cardiac power spectrum and the respiratory power spectrum. A parameter usable to characterize volume responsiveness is determined using above ratio and a correction factor.

Claims

1. Apparatus for determining at least one physiologic parameter of a patient, said apparatus comprising

(a) at least one pressure sensor device adapted to provide readings of a blood pressure of said patient, and

(b) storage means for storing said readings as at least one pressure curve over time,

(c) fourier transformation means for subjecting said at least one pressure curve to a fourier transformation, and

(d) an evaluator adapted to retrieve at least one power value selected from a group consisting of

a cardiac power value representing cardiac power and

a respiratory power value representing respiratory power from at least one fourier transform received from said fourier transformation means and to determine said physiologic parameter from said at least one power value,

wherein said evaluator is adapted to extract at least one power-spectrum selected from the group consisting of

a cardiac power-spectrum and

a respiratory power-spectrum;

from at least one fourier transform received from said fourier transform means to determine a width at a predetermined fraction of the maximum of a peak of said at least one power-spectrum and to use said width to separate harmonics.

2. Apparatus according to claim 1, wherein said evaluator is adapted to separate said harmonics using at least one of a heart rate and a breathing rate as a basic frequency.

3. Apparatus according to claim 1, wherein said evaluator is adapted to determine at least one of

said cardiac power value using summation over at least part of said cardiac power-spectrum

said cardiac power value using integration over at least part of said cardiac power-spectrum

said respiratory power value using summation over at least part of said respiratory power-spectrum

said respiratory power value using integration over at least part of said respiratory power-spectrum.

4. Apparatus according to claim 1, wherein said evaluator is adapted to use said width to determine the amount of said harmonics from at least one of said cardiac power-spectrum and said respiratory power-spectrum.

5. Apparatus according to claim 1, wherein said evaluator is adapted to determine both said cardiac power-value and said respiratory power-value from a fourier transform received from said fourier transformation based on the same pressure curve.

6. Apparatus according to claim 1 comprising at least two pressure sensor devices adapted to provide readings of a blood pressure of said patient,

wherein the apparatus is adapted to store readings of a first one of said pressure sensor devices as a first pressure curve over time and readings of a second one of said pressure sensor devices as a second pressure curve over time,

and wherein said evaluation means are adapted to determine said cardiac power-value from a fourier transform received from said fourier transformation based on said first pressure curve and said respiratory power-value from a fourier transform received from said fourier transformation based on said second pressure curve.

7. Apparatus according to claim 6, wherein said first pressure sensor device is an arterial pressure sensor device and said second pressure device is one of a central venous pressure device and a pulmonary artery pressure device.

8. Apparatus according to claim 6, wherein said evaluation means are adapted to determine cardiac output from the quotient of said cardiac power-value and an averaged pressure calculated from said readings of a blood pressure of said patient.

9. Apparatus according to claim 1, further comprising at least one pressure sensor device adapted for non-invasively measuring an arterial pressure of said patient.

10. Apparatus according to claim 1, wherein said at least one physiologic parameter of said patient includes cardiac output, and wherein said evaluator is adapted to determine cardiac output using said cardiac power-value.

11. Apparatus according to claim 1, wherein said evaluation means are adapted to determine at least one further hemodynamic parameter from said at least one pressure curve over time.

12. Apparatus for determining at least one physiologic parameter of a patient, said apparatus comprising

(a) at least one pressure sensor device adapted to provide readings of a blood pressure of said patient, and

(b) storage means for storing said readings as at least one pressure curve over time,

(c) fourier transformation means for subjecting said at least one pressure curve to a fourier transformation, and

(d) an evaluator adapted to retrieve at least one power value selected from a group consisting of

a cardiac power value representing cardiac power and

a respiratory power value representing respiratory power from at least one fourier transform received from said fourier transformation means and to determine said physiologic parameter from said at least one power value,

wherein said at least one physiologic parameter of the patient includes a parameter indicative of volume-responsiveness.

13. Apparatus according to claim 12, wherein said evaluator is adapted to retrieve both the cardiac power value and the respiratory power value and is adapted to determine said parameter for volume-responsiveness from the quotient of said cardiac power-value and said respiratory power-value.

14. Apparatus according to claim 12, wherein said evaluator is adapted to determine said parameter for volume-responsiveness using a correction factor.

15. Apparatus according to claim 14, wherein said evaluator is adapted to determine said parameter for volume-responsiveness to be a product of said correction factor and the quotient of said cardiac power-value and said respiratory power-value.

16. Apparatus according to claim 14, wherein said evaluator is adapted to determine a cardiac power-spectrum and a respiratory power spectrum from at least one fourier transform received from said fourier transformation, to determine said cardiac power value using summation or integration over at least part of said cardiac power-spectrum and said respiratory power value using summation or integration over at least part of said respiratory power-spectrum, and to determine at least one of the following characteristic parameters

a width (WC, WR) at a predetermined fraction of the maximum of a peak of said cardiac power-spectrum,

a slope of logarithmic spectral density of said cardiac power-spectrum over logarithmic frequency for frequency tending towards infinity,

a slope of logarithmic spectral density of said respiratory power-spectrum over logarithmic frequency for frequency tending towards infinity,

a limit of the spectral density of said cardiac power-spectrum tending towards zero,

a limit of the spectral density of said respiratory power-spectrum tending towards zero,

a limit of the spectral density of the superposition of said cardiac power-spectrum and said respiratory power-spectrum tending towards zero,

and wherein said correction factor is a function of at least one of said characteristic parameters.

17. Apparatus according to claim 12, wherein said evaluator is adapted to separate said harmonics using at least one of a heart rate and a breathing rate as a basic frequency.

18. Apparatus according to claim 12, wherein said evaluator is adapted to determine both said cardiac power-value and said respirator power-value from a fourier transform received from said fourier transformation based on the same pressure curve.

19. Apparatus according to claim 12, wherein at least one pressure sensor device is adapted for non-invasively measuring an arterial pressure of said patient.

20. Apparatus according to claim 12, wherein said at least one physiologic parameter of said patient includes cardiac output, and wherein said evaluator is adapted to determine cardiac output using said cardiac power-value.

21. Apparatus for determining at least one physiologic parameter of a patient, said apparatus comprising

(a) at least one pressure sensor device adapted to provide readings of a blood pressure of said patient, and

(b) storage means for storing said readings as at least one pressure curve over time,

(c) fourier transformation means for subjecting said at least one pressure curve to a fourier transformation, and

(d) an evaluator adapted to retrieve at least one power value selected from a group consisting of

a cardiac power value representing cardiac power and

a respiratory power value representing respiratory power from at least one fourier transform received from said fourier transformation means and to determine said physiologic parameter from said at least one power value,

wherein said at least one physiologic parameter of said patient includes tidal volume, and wherein said evaluation means are adapted to determine tidal volume using said respiratory power-value.