Methods and devices for local therapeutic agent delivery to heart valves

• US 8,556,880 B2
• Filed: 09/05/2008
• Issued: 10/15/2013
• Est. Priority Date: 09/06/2007
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Freyman, Toby, Mickley, Tim, Cheng, Ruth
• Primary Examiner(s): Sirmons, Kevin C
• Assistant Examiner(s): LEE, BRANDY SCOTT
• Application Number:
  US12/205,341
• Publication Number:
  US 20090069789A1
• Time in Patent Office: 1,866 Days
• Field of Search: 604/509, 604/258, 604/523, 604/103.01, 604/508, 514/450, 514/449, 514/460, 514/427, 514/307
• US Class Current: 604/509
• CPC Class Codes: A61M 2025/0024 Expandable catheters or sheaths
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 2025/1086 having a special balloon surface topography, e.g. pores, protuberances, spikes or grooves
• CPC Class Codes: A61M 25/007 Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system

Abstract

Medical devices and methods for delivering a therapeutic agent to a heart valve.

Claims

1. A method for diagnosing or treating a heart valve disease in a subject, comprising:

a) using a device comprising;

an elongate body having a distal end and a longitudinal axis; and

a plurality of delivery members coupled to the elongate body, where each member has a first end, a middle portion, and a second end, and the first and second ends of at least one of the delivery members are coupled to the elongate body at locations that are proximal to the distal end of the elongate body, wherein at least one of the delivery members has a lumen and one or more openings in communication with that lumen;

b) inserting the device into the subject'"'"'s blood vessel;

c) positioning the device inside the subject'"'"'s heart such that a delivery member contacts a heart valve; and

d) applying a therapeutic agent to the heart valve by flowing the therapeutic agent out from the one or more openings of the delivery member having the lumen.

2. The method of claim 1, where the therapeutic agent is rapamycin, paclitaxel, sirolimus, a nitric oxide-enhancing agent, a statin, an angiotensin converting enzyme (ACE) inhibitor, a PPAR agonist, an anti-inflammatory agent, an anti-stenotic agent, an antibiotic, atorvastatin, or quinapril.

3. The method of claim 1, wherein each delivery member is 1-20 cm in length.

4. The method of claim 1, wherein the distance between the distal end of the catheter and the distal-most coupling location of each of the delivery members to the elongate body is 1-15 cm.

5. The method of claim 1, where at least one delivery member is at least partially coated with the therapeutic agent.

6. The method of claim 5, where the therapeutic agent is rapamycin, paclitaxel, sirolimus, a nitric oxide-enhancing agent, a statin, an angiotensin converting enzyme (ACE) inhibitor, a PPAR agonist, an anti-inflammatory agent, an anti-stenotic agent, an antibiotic, atorvastatin, or quinapril.