Coated implantable medical device
First Claim
1. A coated medical device, comprising:
- a vascular stent having an outer surface and a lumen surface;
a coating layer of parylene or a parylene derivative applied to at least the outer surface of the vascular stent;
a bioactive material layer posited on said coating layer, the bioactive material layer comprising a bioactive material comprising dexamethasone or a dexamethasone derivative;
a porous polymeric layer posited over said bioactive material layer, the porous polymeric layer capable of controlling the release of the dexamethasone or dexamethasone derivative from the bioactive material layer; and
an overcoat consisting of phosphatidylcholine applied to said porous polymeric layer.
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0 Petitions
Accused Products
Abstract
A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
168 Citations
12 Claims
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1. A coated medical device, comprising:
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a vascular stent having an outer surface and a lumen surface; a coating layer of parylene or a parylene derivative applied to at least the outer surface of the vascular stent; a bioactive material layer posited on said coating layer, the bioactive material layer comprising a bioactive material comprising dexamethasone or a dexamethasone derivative; a porous polymeric layer posited over said bioactive material layer, the porous polymeric layer capable of controlling the release of the dexamethasone or dexamethasone derivative from the bioactive material layer; and an overcoat consisting of phosphatidylcholine applied to said porous polymeric layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A coated vascular stent, comprising:
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a vascular stent adapted for introduction into a patient, the stent having an outer surface and a lumen surface; a coating layer of parylene or a parylene derivative applied to at least the outer surface of the vascular stent; a bioactive material layer posited on said coating layer, the bioactive material layer comprising an antiproliferative agent that inhibits over proliferation of smooth muscle cells; a porous polymeric layer posited over said bioactive material layer, said porous polymeric layer capable of controlling release of the antiproliferative agent from the bioactive material layer; and an overcoat of phosphatidylcholine applied to said porous polymeric layer. - View Dependent Claims (10, 11, 12)
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Specification