System for washing a sensor structure

• US 8,557,050 B1
• Filed: 09/18/2009
• Issued: 10/15/2013
• Est. Priority Date: 10/31/2008
• Status: Active Grant

• Current Assignee: GeneFluidics, Inc.
• Original Assignee: GeneFluidics, Inc.
• Inventors: Gau, Jen-Jr, Wiita, Chris
• Primary Examiner(s): Kornakov, Michael
• Assistant Examiner(s): Oserhout, Benjamin L.
• Application Number:
  US12/586,280
• Time in Patent Office: 1,488 Days
• Field of Search: 134/34, 134/172, 134/180, 134/181, 134/186, 152/04, 153/02, 153/21
• US Class Current: 134/34
• CPC Class Codes: B08B 3/02 Cleaning by the force of jets or sprays
• CPC Class Codes: G01N 27/12 of a solid body in dependence upon absorption of a fluid; of a solid body in dependence upon reaction with a fluid , for detecting components in the fluid

Abstract

The system includes a wash source configured to concurrently generate a plurality of streams that are each incident on a sensor structure configured to detect a presence and/or amount of a compound on the sensor structure. The sensor structure has electrodes on a substrate. The wash source generates the streams such that each one of the streams is incident on a different one of the electrodes. Each of the streams is incident on one of the electrodes at an angle that is non-perpendicular to the sensor.

Claims

1. A sensor wash system, comprising:

a sensor structure having multiple electrochemical sensors on a substrate, the sensors each being configured to detect a presence and/or amount of a compound on the sensor,

each of the electrochemical sensors including multiple electrodes,

the electrodes in each electrochemical sensor including a working electrode to which compounds are bound such that a portion of the compounds are specifically bound and another portion of the compounds are non-specifically bound;

a wash source concurrently generating a plurality of streams, different streams are each incident on a different one of the working electrodes such that the different streams each removes non-specifically bound compounds from the working electrode that receives the stream while leaving specifically bound compounds bound to the working electrode that receives the stream.

2. The system of claim 1, wherein the wash source is configured to concurrently scan the each of the streams across a surface of the working electrode that receives the stream.

3. The system of claim 1, wherein the wash source generates the streams such that an angle of incidence between each stream and the electrode that receives the stream is in a range of greater than or equal to 5°

and less than or equal to 80°

.

4. The system of claim 1, wherein the wash source generates the streams such that the streams are concurrently incident on different working electrodes.

5. The system of claim 1, wherein the wash source includes a plurality of nozzles and is configured to generate the streams such that each stream exits from a different one of the nozzles and the wash source is configured to move the stream sources vertically relative to the electrodes.

6. The system of claim 1, wherein the wash source includes a plurality of nozzles and is configured to generate the streams such that each stream exits from a different one of the nozzles and the wash source is configured to move the stream sources vertically relative to the electrodes such that the movement of the stream sources is concurrent with the incidence of the streams on the electrodes.

7. The system of claim 1, wherein the wash source includes one or more gas conduits that are each configured to vacuum a liquid off one of the sensors.

8. The system of claim 1, wherein the wash source includes one or more gas conduits that are each configured to apply vacuum suction to one of the electrodes, and

different vacuum tubes are configured to concurrently apply the vacuum suction to a different one of the electrodes.

9. The system of claim 1, wherein the wash source includes one or more gas conduits that are each configured to blow a gas onto one of the electrodes.

10. The system of claim 1, wherein each of the sensors is configured to generate electrical current from a chemical reaction in a solution and/or to use electrical energy to cause a chemical reaction in the solution.

11. The system of claim 1, wherein the non-specifically bound compounds are bound to the working electrode with hydrogen bonds and the specifically bound compounds are bonded to the working electrode with covalent bonds.

12. The system of claim 1, wherein the non-specifically bound compounds include a component selected from a group consisting of DNA, RNA, proteins, and hormones.

13. The system of claim 12, wherein the wash source concurrently scans each of the streams across a surface of the working electrode that receives the stream,

an angle of incidence between each stream and the electrode that receives the stream is in a range of greater than or equal to 5°

and less than or equal to 80°

,

the streams are concurrently incident on different working electrodes.

14. The system of claim 13, wherein the wash source includes sources of each stream and the wash source is configured moves the stream sources vertically relative to the working electrodes.

15. The system of claim 14, wherein the wash source includes one or more gas conduits and employs the gas conduits to vacuum a liquid off one of the sensors.

16. The system of claim 14, wherein the wash source includes one or more gas conduits employs different gas conduits to concurrently vacuum liquid off different working electrodes.

17. The system of claim 16, wherein the wash source employs different gas conduits to blow a gas onto the working electrodes.

18. A method of operating a wash system, comprising:

concurrently spraying streams of a wash liquid onto a sensor structure having multiple electrochemical sensors on a substrate,

the sensors each being configured to detect a presence and/or amount of a compound on the sensor,

each of the electrochemical sensors including multiple electrodes,

the electrodes in each electrochemical sensor including a working electrode to which compounds are bound such that a portion of the compounds are specifically bound and another portion of the compounds are non-specifically bound,

the streams being sprayed such that each one of the streams is incident on a different one of the working electrodes such that the different streams each removes non-specifically bound compounds from the working electrode that receives the stream while leaving specifically bound compounds bound to the working electrode that receives the stream, and

each of the streams being incident on one of the electrodes at an angle that is non-perpendicular to the sensor.

19. The method of claim 18, further comprising:

vacuuming wash liquid off of the electrodes after spraying the streams of the wash liquid onto the sensor structure.

20. The method of claim 18, further comprising:

blowing a gas onto the electrodes after spraying the streams of the wash liquid onto the sensor structure.

21. The method of claim 20, wherein of the electrochemical sensors are each configured to generate electrical current from a chemical reaction in a solution and/or to use electrical energy to cause a chemical reaction in the solution.

22. The method of claim 18, further comprising:

concurrently scanning the streams across a surface of each of the electrodes that receives one of the streams.