Probiotic bifidobacterium strains

• US 8,557,233 B2
• Filed: 03/28/2008
• Issued: 10/15/2013
• Est. Priority Date: 03/28/2007
• Status: Active Grant

• Current Assignee: Alimentary Health Limited
• Original Assignee: Alimentary Health Limited
• Inventors: MacSharry, John, O'Mahony, Liam, O'Sullivan, David, Kiely, Barry
• Primary Examiner(s): Zeman, Robert A
• Application Number:
  US12/450,427
• Publication Number:
  US 20110020284A1
• Time in Patent Office: 2,027 Days
• Field of Search: None
• US Class Current: 424/93.4
• CPC Class Codes: A23L 33/135 Bacteria or derivatives thereof, e.g. probiotics
• CPC Class Codes: A61K 35/745 Bifidobacteria
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 1/12 Antidiarrhoeals
• CPC Class Codes: A61P 1/14 Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
• CPC Class Codes: A61P 1/16 for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 13/00 Drugs for disorders of the urinary system
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 17/06 Antipsoriatics
• CPC Class Codes: A61P 17/10 Anti-acne agents
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 19/10 for osteoporosis
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/00 : Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 3/10 : for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 31/04 : Antibacterial agents
• CPC Class Codes: A61P 31/10 : Antimycotics
• CPC Class Codes: A61P 31/12 : Antivirals
• CPC Class Codes: A61P 31/18 : for HIV
• CPC Class Codes: A61P 35/00 : Antineoplastic agents
• CPC Class Codes: A61P 35/04 : specific for metastasis
• CPC Class Codes: A61P 37/02 : Immunomodulators
• CPC Class Codes: A61P 37/04 : Immunostimulants
• CPC Class Codes: A61P 37/06 : Immunosuppressants, e.g. drugs for graft rejection
• CPC Class Codes: A61P 37/08 : Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14
• CPC Class Codes: A61P 7/00 : Drugs for disorders of the blood or the extracellular fluid
• CPC Class Codes: A61P 7/04 : Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
• CPC Class Codes: A61P 7/06 : Antianaemics
• CPC Class Codes: A61P 9/00 : Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/10 : for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C12N 1/20 : Bacteria; Culture media therefor
• CPC Class Codes: C12N 1/205 : Bacterial isolates
• CPC Class Codes: C12R 2001/01 : Bacteria or Actinomycetales ; using bacteria or Actinomycetales
• CPC Class Codes: Y02A 50/30 : Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Bifidobacterium strain AH1206 or mutants or variants thereof are immunomodulatory following oral consumption and are useful in the prophylaxis and/or treatment of inflammatory activity for example undesirable gastrointestinal inflammatory activity such as inflammatory bowel disease.

Claims

1. An isolated strain of Bifidobacterium longum strain AH1206 deposited at NCIMB with accession number 41382.

2. The Bifidobacterium strain as claimed in claim 1 in the form of viable cells.

3. The Bifidobacterium strain as claimed in claim 1 in the form of non-viable cells.

4. A formulation which comprises a Bifidobacterium strain as claimed in claim 1.

5. The formulation as claimed in claim 4 which further comprises a probiotic material.

6. The formulation as claimed in claim 4 which further comprises a prebiotic material.

7. The formulation as claimed in claim 4 further comprising an ingestable carrier.

8. The formulation as claimed in claim 7 wherein the ingestable carrier is a pharmaceutically acceptable carrier such as a capsule, tablet or powder.

9. The formulation as claimed in claim 7 wherein the ingestible carrier is a food product such as acidified milk, yoghurt, frozen yoghurt, milk powder, milk concentrate, cheese spreads, dressings or beverages.

10. The formulation as claimed in claim 4 which further comprises a protein and/or peptide, in particular proteins and/or peptides that are rich in glutamine/glutamate, a lipid, a carbohydrate, a vitamin, mineral and/or trace element.

11. The formulation as claimed in claim 4 wherein the Bifidobacterium strain is present in an amount of more than 10⁶ cfu per gram of the formulation.

12. The formulation as claimed in claim 4 which further comprises an adjuvant.

13. The formulation as claimed in claim 4 which further comprises a bacterial component.

14. The formulation as claimed in claim 4 which further comprises a drug entity.

15. The formulation as claimed in claim 4 which further comprises a biological compound.

16. A food stuff comprising a Bifidobacterium strain as claimed in claim 1.

17. A medicament comprising a bifidobacterium strain as claimed in claim 1.

18. A medicament for treating asthma and/or allergy comprising a Bifidobacterium strain as claimed in claim 1.

19. The medicament as claimed in claim 18 wherein the medicament is in a form suitable for inhalation.