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Microorganism producing O-phosphoserine and method of producing L-cysteine or derivatives thereof from O-phosphoserine using the same

  • US 8,557,549 B2
  • Filed: 10/20/2011
  • Issued: 10/15/2013
  • Est. Priority Date: 10/20/2010
  • Status: Active Grant
First Claim
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1. A method for producing cysteine or a derivative thereof, comprising:

  • 1) culturing a recombinant microorganism in which the activity of endogeneous phosphoserine phosphatase (SerB) is reduced and the activity of phosphoglycerate dehydrogenase (SerA) is enhanced, to produce O-sphosphoserine (OPS) wherein the SerA has one selected from the group consisting of amino acid sequences of SEQ ID NOS;

    3 to 7; and

    2) reacting the OPS of step

         1) with a sulfide in presence of O-phosphoserine sulfhydrylase (OPSS) or a microorganism expressing OPSS, to produce cysteine or a derivative thereof.

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