Methods and apparatus for measuring analytes using large scale FET arrays
First Claim
1. A readout circuit for a chemical detector, comprising:
- a first operational amplifier coupled to a first bias voltage, the first operational amplifier having a first input and a first output, the first input coupled to a first readout signal line of the chemical detector;
a second operational amplifier coupled to the first bias voltage, the second operational amplifier having a second input and a second output, the second output coupled to a second readout signal line of the chemical detector;
a first transistor having first and second terminals coupled to the first output and second input respectively; and
a current sink coupled to the second input and a second bias voltage;
wherein the first output is coupled to an output signal line.
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Abstract
Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.
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Citations
9 Claims
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1. A readout circuit for a chemical detector, comprising:
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a first operational amplifier coupled to a first bias voltage, the first operational amplifier having a first input and a first output, the first input coupled to a first readout signal line of the chemical detector; a second operational amplifier coupled to the first bias voltage, the second operational amplifier having a second input and a second output, the second output coupled to a second readout signal line of the chemical detector; a first transistor having first and second terminals coupled to the first output and second input respectively; and a current sink coupled to the second input and a second bias voltage; wherein the first output is coupled to an output signal line. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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Specification