Magnetically controlled wireless optical oxygen sensor for intraocular measurements

• US 8,560,033 B2
• Filed: 05/18/2009
• Issued: 10/15/2013
• Est. Priority Date: 05/16/2008
• Status: Expired due to Fees

• Current Assignee: ETH Zurich
• Original Assignee: ETH Zurich
• Inventors: Ergeneman, Olgac, Vollmers, Karl, Abbott, Jake J., Nelson, Bradley
• Primary Examiner(s): SZMAL, BRIAN SCOTT
• Application Number:
  US12/467,661
• Publication Number:
  US 20100022857A1
• Time in Patent Office: 1,611 Days
• Field of Search: 600/310, 600/318, 435/287.1, 174/122.G, 298/25, 298/68
• US Class Current: 600/318
• CPC Class Codes: A61B 5/14555 specially adapted for the eye fundus
• CPC Class Codes: B33Y 80/00 Products made by additive manufacturing

Abstract

A sensor for intraocular measurements moveable within at least one of an vitreous humor of an eye, an aqueous humor of an eye and an intraocular replacement medium. The sensor includes a magnetic body susceptible to magnetic fields and at least one sensor film.

Claims

1. A sensor for intraocular measurements moveable within at least one of a vitreous humor of an eye, an aqueous humor of an eye and an intraocular replacement medium, the sensor comprising:

a magnetic body susceptible to magnetic fields; and

at least one sensor film including a supporting matrix and at least one of a luminescence dye, a fluorescence dye and a phosphorescence dye.

2. The sensor as recited in claim 1, wherein the magnetic body includes at least one of a ferromagnetic material, a ferrimagnetic material, a paramagnetic material and a compound with magnetic properties.

3. The sensor as recited in claim 2, wherein the magnetic body includes the compound with magnetic properties which includes at least one of magnetic particles, nanoparticles and super paramagnetic nanoparticles.

4. The sensor as recited in claim 2, wherein the magnetic body is shaped as a sphere, an oblate spheroid, a prolate spheroid, a plane or a cylinder.

5. The sensor as recited in claim 2, wherein the at least one ferromagnetic material, ferrimagnetic material, paramagnetic material and a compound with magnetic properties is selected from at least one of alloys of iron, nickel and cobalt.

6. The sensor as recited in claim 1, wherein the at least one luminescence dye, fluorescence dye and phosphorescence dye has a luminescence effect susceptible to at least one of a physical parameter, a chemical parameter and the concentration of a chemical analyte.

7. The sensor as recited in claim 1, wherein the supporting matrix includes at least one of a polymer, silica gels and sol-gels.

8. The sensor as recited in claim 7, wherein the polymer is polystyrene.

9. The sensor as recited in claim 1, wherein the at least one luminescence dye, fluorescence dye and phosphorescence dye is at least one of an iridium complex and a ruthenium complex.

10. The sensor as recited in claim 1, wherein the sensor film is disposed on a highly reflecting surface of the magnetic body.

11. The sensor as recited in claim 1, wherein a surface of the magnetic body is coated with at least one of a metal, metal alloy and a polymer.

12. The sensor as recited in claim 11, wherein the at least one metal, metal alloy and polymer is at least one of gold, titanium, polystyrene and polypyrrole.

13. A sensor for at least one in-vivo measurement moveable within at least one of a human or an animal body, the sensor comprising:

a magnetic body susceptible to magnetic fields; and

at least one sensor film having a luminescence activity that depends on at least one of a physical parameter, a chemical parameter and the concentration of a chemical analyte.

14. The sensor according to claim 13, wherein the luminescence activity of the at least one sensor film depends on at least one of a molecular oxygen concentration, a carbon dioxide concentration, a glucose concentration, temperature and pH.