Devices and methods for electrode implantation

• US 8,560,076 B2
• Filed: 11/05/2010
• Issued: 10/15/2013
• Est. Priority Date: 10/22/2003
• Status: Active Grant

• Current Assignee: CVRx, Inc.
• Original Assignee: CVRx, Inc.
• Inventors: Kieval, Robert S., Rossing, Martin
• Primary Examiner(s): Koharski, Christopher D
• Assistant Examiner(s): Patel, Natasha
• Application Number:
  US12/940,798
• Publication Number:
  US 20110137374A1
• Time in Patent Office: 1,075 Days
• Field of Search: 607/2, 607/26, 607/46, 607/11, 607/8, 607/62
• US Class Current: 607/46
• CPC Class Codes: A61N 1/0556 Cuff electrodes
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362

Abstract

Systems and methods provide baroreflex activation to treat or reduce pain and/or to cause or enhance sedation or sleep. Methods involve activating the baroreflex system to provide pain reduction, sedation, improved sleep or some combination thereof. Systems include at least one baroreflex activation device, at least one sensor for sensing physiological activity of the patient, and a processor coupled with the baroreflex activation device(s) and the sensor(s) for processing sensed data received from the sensor and for activating the baroreflex activation device. In some embodiments, the system is fully implantable within a patient, such as in an intravascular, extravascular or intramural location.

Claims

1. A method comprising:

arranging a generally cylindrical expandable and contractible lead member within a lumen of a blood vessel adjacent one or more baroreceptors located within a wall of the blood vessel;

temporarily deploying the cylindrical lead member within the lumen proximate the one or more baroreceptors;

energizing one or more electrodes connected to the cylindrical lead member to deliver electrical stimulation from within the blood vessel lumen to the one or more baroreceptors; and

chronically deploying the cylindrical lead member in an expanded state within the lumen relative to the one or more baroreceptors.

2. The method of claim 1 further comprising determining an efficacy of the electrical stimulation.

3. The method of claim 2 further comprising:

comparing the efficacy of the electrical stimulation to a threshold efficacy; and

redeploying the cylindrical lead member within the lumen relative to the one or more baroreceptors, if the efficacy of the electrical stimulation does not meet or exceed the threshold efficacy.

4. The method of claim 3 wherein, if the efficacy of the electrical stimulation does not meet or exceed the threshold efficacy, then further comprising:

energizing one or more electrodes connected to the redeployed cylindrical lead member to deliver electrical stimulation from within the blood vessel lumen to the one or more baroreceptors; and

determining if an efficacy of the electrical stimulation delivered by the redeployed cylindrical lead member meets or exceeds the threshold efficacy.

5. The method of claim 1, wherein deploying the cylindrical lead member within the lumen relative to the one or more baroreceptors comprises:

orienting the electrodes connected to the cylindrical lead member within the lumen relative to the one or more baroreceptors; and

selecting one or more combinations of the plurality of electrodes to deliver electrical stimulation from within the blood vessel lumen to the one or more baroreceptors.

6. The method of claim 5, wherein deploying the cylindrical lead member within the lumen relative to the one or more baroreceptors further comprises expanding the cylindrical lead member.

7. The method of claim 1, wherein the blood vessel is selected from the group consisting of:

a carotid sinus, an aortic arch, a common carotid artery, a subclavian artery, a brachiocephalic artery, pulmonary artery, pulmonary vein, jugular vein, femoral artery, femoral vein, and a heart.

8. A method comprising:

placing a portion of an implantable medical lead having an electrode electrically connected thereto in an extravascular space defined by a sheath of tissue within a patient and adjacent one or more baroreceptors within the sheath of tissue within the patient; and

anchoring the lead at a location proximally offset from the electrode and at least partially outside of the sheath.

9. The method of claim 8, wherein placing the portion of the medical lead having the electrode in the extravascular space adjacent the one or more baroreceptors within the sheath comprises guiding the medical lead through an incision in the sheath toward the one or more baroreceptors.