Method and apparatus for quantification of cardiac wall motion asynchrony
First Claim
1. A non-transitory computer-readable medium having computer-executable instructions to cause a computer or computer-based system to perform a method for analyzing cardiac wall motion of first and second cardiac regions using cardiac wall motion contours detected an echocardiogram, the method comprising:
- receiving regional displacement magnitudes calculated for the first and second cardiac regions over one cardiac cycle based on cardiac wall motion contours detected from the echocardiogram;
generating first and second regional displacement curves based on the regional displacement magnitudes calculated for the first and second cardiac regions, respectively, the first and second regional displacement curves each being a plot of regional displacement magnitude verses time over the cardiac cycle;
providing a common magnitude reference to the first and second regional displacement curves;
averaging each of the first and second regional displacement curves over a predetermined number of cardiac cycles;
smoothing the averaged first and second regional displacement curves; and
computing a relative phase representing a phase relationship between the first and second regional displacement curves based on a frequency analysis using the smoothed and averaged first and second regional displacement curves, the relative phase indicative of a cardiac wall motion asynchrony.
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Abstract
A phase analysis technique provides for quantification of regional wall motion asynchrony from endocardial border contours generated from two-dimensional echocardiographic ventricular images. The technique produces results including a degree of radial ventricular asynchrony in heart failure patients with ventricular conduction delay to predict a magnitude of contractile function improvement with pacing therapy. Quantification of change in ventricular regional wall motion asynchrony in response to a therapy provides for a means to identify candidates to receive the therapy and quantitatively predict the benefit of the therapy. Quantification of changes in ventricular regional wall motion asynchrony in response to a sequence of therapies provides for a means to determine an approximately optimal therapy for an intended patient response.
41 Citations
27 Claims
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1. A non-transitory computer-readable medium having computer-executable instructions to cause a computer or computer-based system to perform a method for analyzing cardiac wall motion of first and second cardiac regions using cardiac wall motion contours detected an echocardiogram, the method comprising:
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receiving regional displacement magnitudes calculated for the first and second cardiac regions over one cardiac cycle based on cardiac wall motion contours detected from the echocardiogram; generating first and second regional displacement curves based on the regional displacement magnitudes calculated for the first and second cardiac regions, respectively, the first and second regional displacement curves each being a plot of regional displacement magnitude verses time over the cardiac cycle; providing a common magnitude reference to the first and second regional displacement curves; averaging each of the first and second regional displacement curves over a predetermined number of cardiac cycles; smoothing the averaged first and second regional displacement curves; and computing a relative phase representing a phase relationship between the first and second regional displacement curves based on a frequency analysis using the smoothed and averaged first and second regional displacement curves, the relative phase indicative of a cardiac wall motion asynchrony. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method, comprising:
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recording an echocardiogram; detecting cardiac wall motion contours from the echocardiogram; calculating regional displacement magnitudes for first and second cardiac regions over one cardiac cycle based on cardiac wall motion contours; generating first and second regional displacement curves based on the regional displacement magnitudes calculated for the first and second cardiac regions, respectively, the first and second regional displacement curves each being a regional displacement magnitude verses time plot over the cardiac cycle; providing a common magnitude reference to the first and second regional displacement curves; averaging each of the first and second regional displacement curves over a predetermined number of cardiac cycles; smoothing the averaged first and second regional displacement curves; and computing a relative phase representing a phase relationship between the first and second regional displacement curves based on a frequency analysis using the smoothed and averaged first and second regional displacement curves, the relative phase indicative of a degree of cardiac wall motion asynchrony reflected in the echocardiogram. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A method, comprising:
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recording an echocardiogram including at least first and second portions, the first portion recorded when a cardiac therapy is delivered, the second portion recorded when no cardiac therapy is delivered; detecting cardiac wall motion contours from the echocardiogram; calculating regional displacement magnitudes for first and second cardiac regions over one cardiac cycle based on cardiac wall motion contours; generating first and second regional displacement curves based on the regional displacement magnitudes calculated for the first and second cardiac regions, respectively, the first and second regional displacement curves each being a regional displacement magnitude verses time plot over the cardiac cycle; providing a common magnitude reference to the first and second regional displacement curves; averaging each of the first and second regional displacement curves over a predetermined number of cardiac cycles; smoothing the averaged first and second regional displacement curves; computing first and second relative phases each representing a phase relationship between the first and second regional displacement curves based on a frequency analysis, the first relative phase indicative of a degree of cardiac wall motion asynchrony reflected in the first portion of the echocardiogram, the second relative phase indicative of a degree of cardiac wall motion asynchrony reflected in the second portion of the echocardiogram; comparing the computed first and second relative phases; and predicting a response to the cardiac therapy based on an outcome of the comparing. - View Dependent Claims (26, 27)
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Specification