Compositions and methods for administering compartmentalized frozen particles
First Claim
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1. A frozen particle composition, comprising:
- a frozen carbon dioxide particle approximately one micrometer or less, and defining at least one cavity;
the at least one cavity containing at least one agent including a vitamin, vaccine or cytokine; and
wherein the frozen carbon dioxide particle is coated with at least one biological remodeling agent including one or more of calcium phosphate, albumin, fibrin, thrombin, glutaraldehyde-crosslinked pericardium, hyaluronic acid, hydroxyapatite, keratin, ligament, nitinol, polyethylene, polylethylene glycol, polyethylene glycol diacrylate, polyethylene terephthalate fiber, polyglycol, polylactate, polytetrafluoroethylene, fibrinogen, hyaluronate, chitin, chitosan, methylcellulose, alginate, hyaluronic acid, agarose, cellulose, polyaldehyde gluronate, Factor XIII, Factor XII, silk, nylon, collagen, elastin, silicone, polyurethane, ceramic powder, pectin, wax, glycosaminoglycan, poly(α
-hydroxyacid), selectin, or glutaraldehyde.
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Abstract
Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.
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Citations
23 Claims
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1. A frozen particle composition, comprising:
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a frozen carbon dioxide particle approximately one micrometer or less, and defining at least one cavity; the at least one cavity containing at least one agent including a vitamin, vaccine or cytokine; and wherein the frozen carbon dioxide particle is coated with at least one biological remodeling agent including one or more of calcium phosphate, albumin, fibrin, thrombin, glutaraldehyde-crosslinked pericardium, hyaluronic acid, hydroxyapatite, keratin, ligament, nitinol, polyethylene, polylethylene glycol, polyethylene glycol diacrylate, polyethylene terephthalate fiber, polyglycol, polylactate, polytetrafluoroethylene, fibrinogen, hyaluronate, chitin, chitosan, methylcellulose, alginate, hyaluronic acid, agarose, cellulose, polyaldehyde gluronate, Factor XIII, Factor XII, silk, nylon, collagen, elastin, silicone, polyurethane, ceramic powder, pectin, wax, glycosaminoglycan, poly(α
-hydroxyacid), selectin, or glutaraldehyde. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification