Coatings for implantable medical devices

• US 8,563,025 B2
• Filed: 01/23/2006
• Issued: 10/22/2013
• Est. Priority Date: 03/20/2002
• Status: Expired due to Fees

• Current Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Original Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Inventors: Michal, Eugene T., Hossainy, Syed F. A., Shah, Ashok
• Primary Examiner(s): FUBARA, BLESSING M
• Application Number:
  US11/338,058
• Publication Number:
  US 20060121089A1
• Time in Patent Office: 2,829 Days
• Field of Search: 424/426, 514/182, 514/291, 514/449
• US Class Current: 424/426
• CPC Class Codes: A61K 31/337 having four-membered rings, e.g. taxol
• CPC Class Codes: A61K 31/4745 condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines yohimbine derivatives, vinblastine A61K31/475; ergoline derivatives A61K31/48
• CPC Class Codes: A61K 31/56 Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
• CPC Class Codes: A61L 2300/416 Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
• CPC Class Codes: A61L 2300/43 Hormones, e.g. dexamethasone
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C08F 210/02 Ethene
• CPC Class Codes: C08F 216/06 Polyvinyl alcohol ; Vinyl alcohol
• CPC Class Codes: C08F 2800/10 as molar percentages
• CPC Class Codes: C08F 2810/50 wherein the polymer is a copolymer and the modification is taking place only on one or more of the monomers present in minority
• CPC Class Codes: C08F 8/00 Chemical modification by after-treatment graft polymers, block polymers, crosslinking with unsaturated monomers or with polymers C08F251/00 - C08F299/00; of conjugated diene rubbers C08C
• CPC Class Codes: C08F 8/14 Esterification
• CPC Class Codes: C08F 8/30 Introducing nitrogen atoms or nitrogen-containing groups
• CPC Class Codes: C08F 8/32 by reaction with amines
• CPC Class Codes: C08F 8/34 Introducing sulfur atoms or sulfur-containing groups
• CPC Class Codes: C08G 18/6212 Polymers of alkenylalcohols; Acetals thereof; Oxyalkylation products thereof
• CPC Class Codes: C08G 18/711 containing oxygen in addition to isocyanate oxygen
• CPC Class Codes: C08L 2666/02 Organic macromolecular compounds, natural resins, waxes or and bituminous materials
• CPC Class Codes: C08L 2666/04 : Macromolecular compounds according to groups C08L7/00 - C08L49/00, or C08L55/00 - C08L57/00; Derivatives thereof
• CPC Class Codes: C08L 2666/14 : Macromolecular compounds according to C08L59/00 - C08L87/00; Derivatives thereof
• CPC Class Codes: C09D 151/003 : grafted on to macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds C09D151/04, C09D151/06 take precedence
• CPC Class Codes: C09D 151/06 : grafted on to homopolymers or copolymers of aliphatic hydrocarbons containing only one carbon-to-carbon double bond
• CPC Class Codes: C09D 151/08 : grafted on to macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: C09D 175/04 : Polyurethanes

Abstract

The present application teaches a coating having a biologically compatible compound conjugated to, or blended with, a polymer, wherein the polymer includes at least one olefin-derived unit and at least one unit derived from a vinyl alcohol, an allyl alcohol, or derivatives thereof.

Claims

1. A method of fabricating a medical device comprising forming a coating on the device, wherein the coating comprises:

a modified polymer comprising a biologically compatible compound conjugated to a polymer,

wherein the modified polymer is selected from the group consisting of

2. The method of claim 1 further comprising a therapeutic substance.

3. The method of claim 2, wherein the therapeutic substance comprises actinomycin D, estradiol, paclitaxel, docetaxel, or rapamycin.

4. The method of claim 1, wherein the medical device comprises a stent.

5. The method of claim 1, wherein the forming comprises:

reacting the polymer with the biologically compatible compound to create the modified polymer, and

depositing the modified polymer on the medical device.

6. The method of claim 1, wherein the forming comprises:

depositing the polymer on the medical device to produce a coating, and

reacting the coating with a biologically compatible compound to create a modified coating.

7. The method of claim 1, wherein the modified polymer is

8. The method of claim 1, wherein the modified polymer is

9. The method of claim 1, wherein the modified polymer is

10. The method of claim 1, wherein the modified polymer is