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Methods and compositions for modulating PD1

  • US 8,563,314 B2
  • Filed: 11/17/2010
  • Issued: 10/22/2013
  • Est. Priority Date: 09/27/2007
  • Status: Active Grant
First Claim
Patent Images

1. A zinc finger protein comprising four, five or six zinc finger recognition regions ordered from F1 to F4, F1 to F5 or F1 to F6, from N-terminus to C-terminus, and wherein the recognition regions comprise the following amino acid sequences:

  • (i) F1;

    QSGHLSR (SEQ ID NO;

         11), F2;

    RSDSLSV (SEQ ID NO;

         2), F3;

    HNDSRKN (SEQ ID NO;

         3), F4;

    RSDDLTR (SEQ ID NO;

         4), and F5;

    RSDHLTQ (SEQ ID NO;

         5);

    (ii) F1;

    RSAALSR (SEQ ID NO;

         6), F2;

    RSDDLTR (SEQ ID NO;

         4), F3;

    RSDHLTT (SEQ ID NO;

         7), F4;

    DRSALSR (SEQ ID NO;

         8), and F5;

    DRSALAR (SEQ ID NO;

         9);

    (iii) F1;

    RSAALAR (SEQ ID NO;

         10), F2;

    RSDDLSK (SEQ ID NO;

         11), F3;

    RNDHRKN (SEQ ID NO;

         12), F4;

    DRSALSR (SEQ ID NO;

         8), and F5;

    DRSALAR (SEQ ID NO;

         9);

    (iv) F1;

    RSDHLSE (SEQ ID NO;

         13), F2;

    TSSDRTK (SEQ ID NO;

         14), F3;

    RSDHLSE (SEQ ID NO;

         13), and F4;

    QSASRKN (SEQ ID NO;

         15);

    (v) F1;

    RSDVLSE (SEQ ID NO;

         16), F2;

    RSANLTR (SEQ ID NO;

         17), F3;

    RSDHLSQ (SEQ ID NO;

         18), F4;

    TSSNRKT (SEQ ID NO;

         19), F5;

    DRSNLSR (SEQ ID NO;

         20), and F6;

    RSDALAR (SEQ ID NO;

         21);

    or(vi) F1;

    DDWNLSQ (SEQ ID NO;

         22), F2;

    RSANLTR (SEQ ID NO;

         17), F3;

    RSDHLSQ (SEQ ID NO;

         18), F4;

    TSSNRKT (SEQ ID NO;

         19), F5;

    DRSNLSR (SEQ ID NO;

         20), and F6;

    RSDALAR (SEQ ID NO;

         21),wherein the zinc finger protein is capable of binding a target site in an endogenous human PD1 gene.

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