Free-standing biodegradable patch
First Claim
1. A method of delivering a patch to bodily tissue, comprising:
- advancing a free-standing film comprising unreacted fibrinogen and a plasticizer that comprises about 5 to about 30 weight percent polyethylene glycol to a target location within a body;
exposing the film to moisture in the body while applying the film to a bodily tissue, during which the film forms an adherent patch.
1 Assignment
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Accused Products
Abstract
Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents.
64 Citations
9 Claims
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1. A method of delivering a patch to bodily tissue, comprising:
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advancing a free-standing film comprising unreacted fibrinogen and a plasticizer that comprises about 5 to about 30 weight percent polyethylene glycol to a target location within a body; exposing the film to moisture in the body while applying the film to a bodily tissue, during which the film forms an adherent patch. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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Specification