Azepine inhibitors of Janus kinases

• US 8,563,541 B2
• Filed: 05/23/2012
• Issued: 10/22/2013
• Est. Priority Date: 09/22/2005
• Status: Active Grant

• Current Assignee: Incyte Holdings Corporation And Incyte Corporation
• Original Assignee: Incyte Corporation
• Inventors: Arvanitis, Argyrios G., Rodgers, James D., Combs, Andrew P., Sparks, Richard B., Robinson, Darius J.
• Primary Examiner(s): Aulakh, Charanjit
• Application Number:
  US13/479,045
• Publication Number:
  US 20120329782A1
• Time in Patent Office: 517 Days
• Field of Search: 514/215, 540/578, 540/577
• US Class Current: 514/215
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 17/04 Antipruritics
• CPC Class Codes: A61P 17/06 Antipsoriatics
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 21/04 for myasthenia gravis
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 31/14 for RNA viruses
• CPC Class Codes: A61P 31/18 for HIV
• CPC Class Codes: A61P 31/20 for DNA viruses
• CPC Class Codes: A61P 31/22 for herpes viruses
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 35/02 specific for leukemia
• CPC Class Codes: A61P 35/04 : specific for metastasis
• CPC Class Codes: A61P 37/00 : Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 37/02 : Immunomodulators
• CPC Class Codes: A61P 37/06 : Immunosuppressants, e.g. drugs for graft rejection
• CPC Class Codes: A61P 37/08 : Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 5/14 : of the thyroid hormones, e.g. T3, T4
• CPC Class Codes: A61P 9/10 : for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C07D 471/14 : Ortho-condensed systems
• CPC Class Codes: C07D 471/22 : in which the condensed systems contains four or more hetero rings
• CPC Class Codes: C07D 487/14 : Ortho-condensed systems
• CPC Class Codes: C07D 487/22 : in which the condensed system contains four or more hetero rings

Abstract

The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.

Claims

1. A compound of Formula Ia, Ib, or Ic:

2. The compound of claim 1, or pharmaceutically acceptable salt thereof, having Formula Ia.

3. The compound of claim 1, or pharmaceutically acceptable salt thereof, having Formula Ib.

4. The compound of claim 1, or pharmaceutically acceptable salt thereof, having Formula Ic.

5. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein E is NR^2a.

6. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein E is NH or NOH.

7. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein G is N.

8. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein E is NH or NOH and G is N.

9. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein E is NH and G is N.

10. The compound of claim 1, or pharmaceutically acceptable salt thereof, having Formula Ia, wherein E is NH or NOH, and G is N.

11. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein Q¹ is N and Q² is CR^2c.

12. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein Q¹ is CR^2c and Q² is N.

13. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein each D¹, D², and D³ is CR¹.

14. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein each D¹, D², and D³ is CH.

15. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein each D⁴, D⁵, D⁶, and D⁷ is CR¹.

16. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein each D⁴, D⁵, and D⁷ is CR¹ and D⁶ is N.

17. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein D⁴ and D⁷ are CH.

18. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein D⁵ is CR¹ and R¹ is H or halo.

19. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein D⁶ is CR¹ and R¹ is halo.

20. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein D⁶ is CF.

21. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein D⁶ is N.

22. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein D⁵ is CH or CF.

23. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein —

W¹—

W²—

W³—

W⁴ is C_1-6 alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl, each optionally substituted by 1, 2, or 3 halo, C_1-4 alkyl, C_1-4 haloalkyl, C_1-4 haloalkylcarbonyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, —

COOH, —

COO—

(C_1-4 alkyl), OH, C_1-4 alkoxy, C_1-4 haloalkoxy, hydroxyalkyl, CN, cyanoalkyl, alkylthio, arylthio, haloalkylthio, alkylsulfinyl, alkylsulfonyl, arylsulfinyl, arylsulfonyl, aryloxy, cycloalkyloxy, arylalkyloxy, aminocarbonyl, aminocarbonylalkyl, cyanoalkylcarbonyl, formyl, alkylcarbonyl, amino, alkylamino, alkylcarbonylamino, alkyloxycarbonylamino, or dialkylamino optionally substituted by CN.

24. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein —

W¹—

W²—

W³—

W⁴ is C_1-6 alkyl, aryl, arylalkyl, cycloalkyl, heteroaryl, heterocycloalkyl, or heterocycloalkylalkyl, each optionally substituted by 1, 2, or 3 halo, C_1-4 alkyl, C_1-4 haloalkyl, C_1-4 haloalkylcarbonyl, aryl, —

COO—

(C_1-4 alkyl), OH, C_1-4 alkoxy, C_1-4 haloalkoxy, hydroxyalkyl, CN, cyanoalkyl, alkylthio, haloalkylthio, alkylsulfinyl, alkylsulfonyl, arylalkyloxy, aminocarbonyl, aminocarbonylalkyl, cyanoalkylcarbonyl, formyl, alkylcarbonyl, alkyloxycarbonylamino, alkylcarbonylamino, or dialkylamino optionally substituted by CN.

25. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein —

W¹—

W²—

W³—

W⁴ is methyl, ethyl, propyl, butyl, pentyl, hexyl, phenyl, naphthyl, biphenyl, benzyl, phenylethyl, phenylpropyl, cyclopropyl, cyclohexyl, cyclohexenyl, bicyclo[2.2.1]hept-2-enyl, cyclopentyl, pyridyl, pyrryl, imidazolyl, isoxazolyl, thiazolyl, quinolinyl, piperidinyl, tetrahydrofuranyl, pyrrolidinyl, benzo[1,3]dioxolyl, (piperidin-4-yl)methyl, (piperidin-3-yl)methyl, (tetrahydropyran-4-yl)-methyl, (tetrahydrothiopyran-4-yl)-methyl, each optionally substituted by 1, 2, or 3 halo, C_1-4 alkyl, C_1-4 haloalkyl, C_1-4 haloalkylcarbonyl, aryl, —

COO—

(C_1-4 alkyl), OH, C_1-4 alkoxy, C_1-4 haloalkoxy, hydroxyalkyl, CN, cyanoalkyl, cyanoalkylcarbonyl, alkylthio, haloalkylthio, alkylsulfinyl, alkylsulfonyl, arylalkyloxy, aminocarbonyl, aminocarbonylalkyl, cyanoalkylcarbonyl, formyl, alkylcarbonyl, alkyloxycarbonylamino, alkylcarbonylamino, or dialkylamino optionally substituted by CN.

26. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein —

W¹—

W²—

W³—

W⁴ is phenyl, pyrazyl, pyrindyl, pyrryl, indolyl, furyl, thienyl, or benzothienyl, each optionally substituted by 1, 2, 3, 4, or 5 halo, C_1-4 alkyl, C_1-4 haloalkyl, aryl, OH, C_1-4 alkoxy, hydroxyalkyl, CN, cyanoalkyl, alkylthio, haloalkylthio, alkylsulfinyl, alkylsulfonyl, cycloalkyl, heterocycloalkyl, cycloalkylakyl, heterocyclyoalkylalkyl, amino, dialkylamino, aminoalkyl, or aminosulfonyl.

27. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein —

W¹—

W²—

W³—

W⁴ is phenyl optionally substituted by 1, 2, 3, 4, or 5 halo, C_1-4 alkyl, C_1-4 haloalkyl, aryl, OH, C_1-4 alkoxy, hydroxyalkyl, CN, cyanoalkyl, alkylthio, haloalkylthio, alkylsulfinyl, alkylsulfonyl, cycloalkyl, heterocycloalkyl, cycloalkylakyl, heterocyclyoalkylalkyl, amino, dialkylamino, aminoalkyl, or aminosulfonyl.

28. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein —

W¹—

W²—

W³—

W⁴ is phenyl optionally substituted by 1, 2, 3, 4, or 5 halo, C_1-4 alkyl, C_1-4 haloalkyl, aryl, OH, C_1-4 alkoxy, CN, cyanoalkyl, alkylthio, or amino.

29. The compound of claim 1, or pharmaceutically acceptable salt thereof, having Formula IIa or IIb:

30. The compound of claim 1, or pharmaceutically acceptable salt thereof, having Formula IIIa or IIIb:

31. The compound of claim 1, or pharmaceutically acceptable salt thereof, having Formula IVa or IVb:

32. The compound of claim 1, or pharmaceutically acceptable salt thereof, having Formula IVc or IVd:

33. The compound of claim 1, or pharmaceutically acceptable salt thereof, having Formula IVe:

34. The compound of claim 1, or pharmaceutically acceptable salt thereof, having Formula Va or Vb:

35. The compound of claim 1, or pharmaceutically acceptable salt thereof, having Formula VIa or VIb:

36. The compound of claim 1, or pharmaceutically acceptable salt thereof, having Formula VIIa or VIIb:

37. The compound of claim 1 selected from:

2-tert-butyl-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine;

2-cyclopropyl-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine;

2-cyclohexyl-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine;

10-fluoro-2-isobutyl-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine;

2-cyclopentyl-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine;

10-fluoro-2-(tetrahydrofuran-3-yl)-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine;

2-cyclohex-3-en-1-yl-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine;

Trans ethyl (1R, S)-2-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)cyclopropanecarboxylate;

2-bicyclo[2.2.1]hept-5-en-2-yl-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine;

[(1S)-2-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)cyclopropyl]methanol;

2-(1-ethylpentyl)-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine;

4-ethyl-4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)hexanenitrile;

2-cyclopentyl-10,11-difluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine;

2-(1-ethylpentyl)-10,11-difluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine;

3-[1-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)cyclohexyl]propanenitrile;

4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)-4-methylpentanenitrile;

2-(1-ethylpropyl)-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine;

10-fluoro-2-[2-(methylthio)ethyl]-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine;

10-fluoro-2-[2-(methylsulfinyl)ethyl]-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine;

2-[(benzyloxy)methyl]-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine;

Cis-[4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)cyclohexyl]methanol;

Trans-[4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)cyclohexyl]methanol;

Cis-4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)cyclohexanol;

Trans-4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)cyclohexanol;

Trans-[4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)cyclohexyl]acetonitrile;

2-[4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)cyclohexyl]acetamide;

tert-butyl 4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)piperidine-1-carboxylate;

10-fluoro-2-piperidin-4-yl-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine;

3-[4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)piperidin-1-yl]-3-oxopropanenitrile;

2-(1-acetylpiperidin-4-yl)-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine;

10-fluoro-2-[1-(methylsulfonyl)piperidin-4-yl]-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine;

[4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)piperidin-1-yl]acetonitrile;

ethyl [4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)piperidin-1-yl]acetate;

2-[4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)piperidin-1-yl]ethanol;

3-[4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)piperidin-1-yl]propan-1-ol;

4-[4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)piperidin-1-yl]butanenitrile;

10-fluoro-2-[3-methyl-5-(trifluoromethyl)-1H-pyrazol-4-yl]-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine;

2-[3-(difluoromethyl)-5-methyl-1H-pyrazol-4-yl]-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine;

2-(3,5-dimethyl-1H-pyrazol-4-yl)-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine;

2-(3,5-diethyl-1H-pyrazol-4-yl)-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine;

[4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetonitrile;

2-(2-chloro-6-methylphenyl)-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine;

2-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)-3-methylbenzonitrile;

2-(2,6-dimethylphenyl)-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine;

2-(3,5-dichloropyridin-4-yl)-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine; and

2-(2,4-dimethylpyridin-3-yl)-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine;

or a pharmaceutically acceptable salt thereof.

38. The compound of claim 1 selected from:

4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-4-ethylhexanenitrile;

2-[4-(hydroxymethyl)-cyclohexyl]-imidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-3(8H)-ol;

[4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)cyclohexyl]methanol;

[4-(3-hydroxy-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)cyclohexyl]acetonitrile;

[4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)cyclohexyl]acetonitrile;

3-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-3-methylbutanenitrile;

3-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-3-ethylpentanenitrile;

[3-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)cyclopentyl]acetonitrile;

3-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)cyclopentanecarbonitrile;

2-(3,5-dichloropyridin-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,6-dichlorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,6-dimethylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2-fluoro-6-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(6-chloro-2-fluoro-3-methylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[2-fluoro-6-(trifluoromethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2-chloro-6-fluoro-3-methylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[3-chloro-2-fluoro-6-(trifluoromethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2-chloro-6-fluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[2-chloro-5-(trifluoromethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,6-difluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,5-dichlorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(3,5-dibromopyridin-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2-bromophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2-methylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2-chlorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2-ethylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,5-dimethylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[2-chloro-3-(trifluoromethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[2,5-bis(trifluoromethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(3-chloro-2,6-difluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[2-(trifluoromethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,3-dichlorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

3-[[4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-ylphenyl](ethyl)amino]propanenitrile;

2-(2-chloro-3,6-difluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(3-bromopyridin-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(5-bromo-2,3-dimethoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[3-chloro-2-fluoro-5-(trifluoromethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(3-chloropyridin-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,3-dimethylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[2-fluoro-3-(trifluoromethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(3-fluoro-2-methylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2-fluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(5-bromo-2-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[2-fluoro-5-(trifluoromethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2-fluoro-3-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2-fluoro-5-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,3-difluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-quinolin-4-yl-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(5-fluoro-2-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(5-bromo-2-fluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,5-dimethoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,5-difluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(3,5-dimethyl-1H-pyrrol-2-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,6-dimethoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(4-methyl-1H-imidazol-5-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-3,5-dimethoxyphenol;

2-(2-pentafluoroethyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(5-bromo-1,3-benzodioxol-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-4-phenylpentanenitrile;

2-[2-fluoro-4-(trifluoromethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(cyclohexylmethyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

3-bromo-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-6-methoxyphenol;

2-(2-fluoropyridin-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-biphenyl-2-yl-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

methyl-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)benzoate;

2-[2-(ethylthio)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(1H-pyrrol-2-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-{4-[(trifluoromethyl)thio]phenyl}-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2-naphthyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

tert-butyl[1-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-2-phenethyl]carbamate;

2-pyrrolidin-2-yl-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2-chloro-6-methoxyquinolin-3-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(1-acetylpyrrolidin-2-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(1,3-thiazol-2-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

1-acetyl-5-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)pyrrolidin-3-ol;

N-[1-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)ethyl]acetamide;

tert-butyl 2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-4-hydroxypyrrolidine-1-carboxylate;

N-[4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)phenyl]acetamide;

2-[4-(difluoromethoxy)phenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(6-chloropyridin-3-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

6-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-2(methylthio)nicotinonitrile;

2-(3-fluoropyridin-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(6-methoxypyridin-3-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(6-bromopyridin-3-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(6-bromopyridin-2-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(1H-imidazol-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(3-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(4-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[2-(methylthio)ethyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(piperidin-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

3-[4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)piperidin-1-yl]-3-oxopropanenitrile;

3-[3-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)piperidin-1-yl]-3-oxopropanenitrile;

3-(4-((3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)methyl)piperidin-1-yl)-3-oxopropanenitrile;

3-(3-((3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)methyl)piperidin-1-yl)-3-oxopropanenitrile;

2-[1-(trifluoroacetyl)piperidin-4-yl]3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[1-(trifluoroacetyl)piperidin-3-yl]3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-{[1-(trifluoroacetyl)piperidin-4-yl]methyl}-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-{[1-(trifluoroacetyl)piperidin-3-yl]methyl}-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(1-acetylpiperidin-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

3-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)piperidine-1-carbaldehyde;

2-[(1-acetylpiperidin-4-yl)methyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[(1-acetylpiperidin-3-yl)methyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(1-methylpiperidin-3-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)benzonitrile;

4-(3-hydroxy-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)benzonitrile;

3-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)benzonitrile;

2-pyridin-3-yl-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-pyridin-3-ylimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-3(8H)-ol;

2-pyridin-2-ylimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-3(8H)-ol;

2-pyridin-4-yl-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-pyridin-4-ylimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-3(8H)-ol;

2-piperidin-3-yl-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[4-(trifluoromethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[6-(trifluoromethyl)pyridine-3-yl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[3-(trifluoromethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(3,5-dimethylisoxazol-4-yl)imidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-3(8H)-ol;

2-[4-(methylthio)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[4-(methylthio)phenyl]imidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-3(8H)-ol;

2-[4-(methylsulfonyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(1H-imidazol-2-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(1-methyl-1H-imidazol-2-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-phenyl-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-phenylimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-3(8H)-ol;

2-benzyl-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-benzylimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-3(8H)-ol;

2-(2-phenethyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2-phenethyl)imidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-3(8H)-ol;

2-piperidin-4-yl-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-piperidin-4-yl imidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-3(8H)-ol;

2-(piperidin-4-ylmethyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(piperidin-4-ylmethyl) imidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-3(8H)-ol;

2-(piperidin-3-ylmethyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(tetrahydro-2H-pyran-4-ylmethyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(tetrahydro-2H-pyran-4-ylmethyl)imidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-3(8H)-ol;

2-(tetrahydro-2H-thiopyran-4-ylmethyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(tetrahydro-2H-thiopyran-4-ylmethyl)imidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-3(8H)-ol;

2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[3-(difluoromethyl)-5-methyl-1H-pyrazol-4-yl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[1-(4-methoxybenzyl)-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[1,5-dimethyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[1-ethyl-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[1-(cyclopropylmethyl)-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[3-methyl-5-(pentafluoroethyl)-1H-pyrazol-4-yl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-N,N,5-trimethyl-3-(trifluoromethyl)-1H-pyrazole-1-sulfonamide;

2-[3-[chloro(difluoro)methyl]-5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[3-(difluoromethyl)-5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(3,5-dimethyl-1H-pyrazol-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(3-isobutyl-5-methyl-1H-pyrazol-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(3-ethyl-5-methyl-1H-pyrazol-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(3-butyl-5-methyl-1H-pyrazol-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(3,5-diethyl-1H-pyrazol-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(5-cyclopropyl-3-methyl-1H-pyrazol-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2-chloro-6-methylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-3-methylbenzonitrile;

2-(2,4-dimethyl-3-thienyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[4-methylsulfinyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[4-(ethylthio)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[2-(5-methyl-2-furyl)propyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(1-benzothien-5-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,4-dimethyl-1,3-thiazol-5-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(5-methyl-3-phenylisoxazol-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(4-chloro-1-methyl-1H-pyrazol-3-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(1,3,5-trimethyl-1H-pyrazol-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(3,5-dimethylisoxazol-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[1-(2-methoxyethyl)-2,5-dimethyl-1H-pyrrol-3-yl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(1-cyclopropyl-2,5-dimethyl-1H-pyrrol-3-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[2,5-dimethoxy-4-(methylthio)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(trifluoromethyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,4-dimethoxy-3-methylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[2-(methylthio)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2-ethoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,4-dimethoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,3,4,5,6-pentamethylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2-chloro-4-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2-methyl-4-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)phenol;

2-(2,5-dimethyl-4-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2-chloro-3,4-dimethoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,3-dimethyl-4-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,6-dichloro-3,4-dimethoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2,4-dichloro-3-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-6-methoxyphenol;

2-(2,4,5-trimethylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,4-dichlorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2-chloro-4-fluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,4-dimethylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[2-(trifluoromethoxy)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[2-(difluoromethoxy)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2-methoxypyridin-3-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[4-fluoro-2-(trifluoromethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,4,6-trimethylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-chloro-3-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-6-methoxyphenol;

2-(3-methylpyridin-2-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-3-ethoxy-N,N-diethylaniline;

2-(2,5-dimethoxy-4-bromophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2-isobutoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

3-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)pyridine-2-amine;

2-(1H-indol-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-{2-[(trifluormethyl)thio]phenyl}-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

4-bromo-3-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)phenol;

2-[2-chloro-4-(methylsulfonyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,2-difluoro-1,3-benzodioxol-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

4]azepine;

4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-3,5-dimethylphenol;

2-(2-chloro-4,6-dimethoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(3-chlorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[3-fluoro-5-(trifluoromethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(3,5-dichlorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(3-chloro-4-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(6-chloro-1,3-benzodioxol-5-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(4-chloro-2,6-difluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(6-chloro-2,3-difluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,6-dichloro-3-fluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2-chloro-6-fluoro-3-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,4,6-trifluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[2-methoxy-4-(trifluoromethoxy)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(3-chloro-4-fluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(4-fluoro-2-methylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,4-dichloro-6-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,6-dichloro-3-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,6-dichloro-4-methylthiophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[2,6-dichloro-4-(methylsulfinyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[2,6-dichloro-4-(methylsulfonyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(6-chloro-2-fluoro-3-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2-chloro-6-fluoro-4-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

[3,5-dichloro-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)phenyl]methanol;

[3,5-difluoro-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)phenyl]methanol;

3,5-dichloro-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)phenol;

5-chloro-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)nicotinonitrile;

4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)pyridine-3,5-dicarbonitrile;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-3-fluoro-6-methylbenzonitrile;

4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)nicotinonitrile;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-3,6-difluorobenzonitrile;

3-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-2-fluoro-4-(trifluoromethyl)benzonitrile;

3-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-4-methoxybenzonitrile;

6-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-2,3-dimethoxybenzonitrile;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-4,5-dimethoxyisophthalonitrile;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-4-hydroxy-5-methoxyisophthalonitrile;

4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-2,5-dimethoxybenzonitrile;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-5-(methylsulfonyl)benzonitrile;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-3,5-dimethoxybenzonitrile;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-3,5-difluorobenzonitrile;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-3,4-difluorobenzonitrile;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-3-fluoro-6-methoxybenzonitrile;

5-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-2-fluorobenzonitrile;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-3-fluoro-4-methoxybenzonitrile;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-3-fluoro-5-methoxybenzonitrile;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-5-(methylthio)isophthalonitrile;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-5-(hydroxymethyl)isophthalonitrile;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-5-(hydroxymethyl)benzonitrile;

[3,5-dichloro-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)phenyl]acetonitrile;

5-(cyanomethyl)-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)isophthalonitrile;

5-(cyanomethyl)-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)benzonitrile;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-5-(methylsulfinyl)benzonitrile;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-5-(methylsulfonyl)isophthalonitrile;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-5-hydroxybenzonitrile;

1-[3,5-dichloro-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)phenyl]-N,N-dimethylmethanamine;

2-[2,6-dichloro-4-(morpholin-4-ylmethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[2,6-dichloro-4-(thiomorpholin-4-ylmethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[2,6-dichloro-4-(methoxymethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[2,6-dichloro-4-(ethylthio)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[2,6-dichloro-4-(isopropylthio)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[2,6-dichloro-4-(ethylsulfinyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[2,6-dichloro-4-(ethylsulfonyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[2,6-dichloro-4-(isopropylsulfinyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[2,6-dichloro-4-(isopropylsulfonyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-5-(isopropylsulfonyl)benzonitrile;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-5-(ethylthio)isophthalonitrile;

3-chloro-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-5-(ethylthio)benzonitrile;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-5-(isopropylthio)isophthalonitrile;

3-chloro-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-5-(isopropylthio)benzonitrile;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-5-(isopropylsulfinyl)isophthalonitrile;

3-chloro-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-5-(isopropylsulfinyl)benzonitrile;

2-[3,5-dichloro-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)phenoxy]acetonitrile;

2-[3,5-dichloro-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)phenoxy]propanenitrile;

5-(1-cyanoethoxy)-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)isophthalonitrile;

5-(1-cyanoethoxy)-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)benzonitrile;

5-(cyanomethoxy)-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)isophthalonitrile;

2-[3,5-dichloro-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)phenoxy]propanamide;

2-[3,5-dicyano-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)phenoxy]propanamide;

5-(2-amino-1-methyl-2-oxoethoxy)-3-cyano-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)benzamide;

5-(2-amino-1-methyl-2-oxoehtoxy)-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)isophthalamide;

2-[3,5-dichloro-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)phenoxy]acetamide;

2-[3,5-dicyano-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)phenoxy]acetamide;

2-cyano-2-[3,5-dichloro-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)phenoxy]-N,N-dimethylacetamide;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)isophthalonitrile;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)benzonitrile;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-4-hydroxybenzonitrile;

4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-1,3-benzodioxole-5-carbonitrile;

3-chloro-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)benzonitrile;

3-fluoro-4-methyl-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)benzonitrile;

3-fluoro-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)benzonitrile;

3-methoxy-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)benzonitrile;

5-fluoro-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)benzonitrile;

3-chloro-6-methoxy-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)benzonitrile;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-4-methoxyisophthalonitrile;

tert-butyl [4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)pyridin-3-yl]carbamate;

tert-butyl [4-(3-hydroxy-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)pyridin-3-yl]carbamate;

2-(3,5-dimethylpyridin-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

3,5-dichloro-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)phenol;

2-(2,6-dichloro-4-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,6-dichloro-4-ethoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,6-dichloro-4-isopropoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[2,6-dichloro-4-(trifluoromethoxy)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(3-methylpyridin-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2-methylpyridin-3-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,4-dimethylpyridin-3-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(5-chloro-2-ethoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(5-chloro-2-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(5-bromo-2-ethoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-(2,3-difluoro-6-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

2-[2,6-dichloro-4-(trifluoromethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

3,5-dichloro-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-N,N-dimethylaniline;

2-(2,6-dichloro-4-fluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepine;

3-chloro-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-5-methoxybenzonitrile;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-5-methoxyisophthalonitrile;

3-chloro-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-5-ethoxybenzonitrile;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-5-ethoxyisophthalonitrile;

3-chloro-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-5-isopropoxybenzonitrile;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-5-isopropoxyisophthalonitrile;

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-5-(trifluoromethoxy)isophthalonitrile;

3-chloro-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-5-(trifluoromethyl)benzonitrile;

3-chloro-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-5-(dimethylamino)benzonitrile; and

3-chloro-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

4′

,3′

-f]azepin-2-yl)-5-fluorobenzonitrile;

or a pharmaceutically acceptable salt thereof.

39. The compound of claim 1 selected from:

2-(3,5-dichloropyridin-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

3′

,4′

-f]azepine;

2-(2,6-dichlorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

3′

,4′

-f]azepine;

2-(2,6-difluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

3′

,4′

-f]azepine;

2-(2-chloro-6-fluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

3′

,4′

-f]azepine;

2-(2,6-dimethylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

3′

,4′

-f]azepine;

4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

3′

,4′

-f]azepin-2-yl)-4-ethylhexanenitrile;

2-[1-(4-methoxybenzyl)-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]imidazo[4,5-d]dipyrido[2,3-b;

3′

,4′

-f]azepin-3(8H)-ol;

2-[1-(4-methoxybenzyl)-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

3′

,4′

-f]azepine;

2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]imidazo[4,5-d]dipyrido[2,3-b;

3′

,4′

-f]azepin-3(8H)-ol;

2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

3′

,4′

-f]azepine;

2-(2,3-dimethylphenyl)imidazo[4,5-d]dipyrido[2,3-b;

3′

,4′

-f]azepin-3(8H)-ol;

2-(2,3-dimethylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

3′

,4′

-f]azepine;

2-[2-(dimethylamino)-pyridin-3-yl]imidazo[4,5-d]dipyrido[2,3-b;

3′

,4′

-f]azepin-3(8H)-ol;

3-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

3′

,4′

-f]azepin-2-yl)-N,N-dimethylpyridin-2-amine; and

2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;

3′

,4′

-f]azepin-2-yl)-3-fluorobenzonitrile;

or a pharmaceutically acceptable salt thereof.

40. The compound of claim 1 which is 2-(2,6-dichlorophenyl)-2,8-dihydropyrazolo[3,4-d]dipyrido[2,3-b:

3′

,4′

-f]azepine or pharmaceutically acceptable salt thereof.

41. A composition comprising a compound of claim 1, or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

42. The composition of claim 41 for topical administration.

43. The composition of claim 42 wherein said topical administration comprises transdermal administration.

44. The composition of claim 43 which is in the form of a transdermal patch, ointment, lotion, cream, or gel.