Fatty acid formulations and oral delivery of proteins and peptides, and uses thereof
First Claim
1. A pharmaceutical composition formulated for oral administration by ingestion, comprising:
- (a) from about 5 to about 65% w/w of a salt of a fatty acid component, wherein the salt of the fatty acid component is selected from salt of capric acid, salt of lauric acid and combinations thereof; and
(b) an insulin compound conjugate comprising an insulin protein coupled to a modifying moiety having a structure;
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Abstract
Fatty acid compositions for administration of of pharmaceutical agents, such as proteins and peptides, protein and peptide conjugates, and/or cation-polypeptide conjugate complexes. In particular, the invention provides a solid pharmaceutical composition formulated for oral administration by ingestion, having from about 0.1 to about 75% w/w fatty acid component, where the fatty acid component comprises saturated or unsaturated C4, C5, C6, C7, C8, C9, C10, C11, or C12 fatty acids and/or salts of such fatty acids; and a therapeutic agent. Further, the invention provides a liquid pharmaceutical composition formulated for oral administration by ingestion, comprising: from about 0.1 to about 10% w/v fatty acid component, where the fatty acid component comprises saturated or unsaturated C4, C5, C6, C7, C8, C9, C10, C11, or C12 fatty acids and/or salts of such fatty acids; and a therapeutic agent.
244 Citations
12 Claims
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1. A pharmaceutical composition formulated for oral administration by ingestion, comprising:
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(a) from about 5 to about 65% w/w of a salt of a fatty acid component, wherein the salt of the fatty acid component is selected from salt of capric acid, salt of lauric acid and combinations thereof; and (b) an insulin compound conjugate comprising an insulin protein coupled to a modifying moiety having a structure; - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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Specification