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Methods and compositions involving miRNA and miRNA inhibitor molecules

  • US 8,563,708 B2
  • Filed: 08/10/2007
  • Issued: 10/22/2013
  • Est. Priority Date: 11/12/2004
  • Status: Expired due to Fees
First Claim
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1. A synthetic RNA molecule comprising two polynucleotides each between 17 and 25 residues in length comprisinga) a first polynucleotide comprising an miRNA region whose sequence from 5′

  • to 3′

    is identical to a mature miRNA sequence, andb) a second polynucleotide comprising a complementary region whose sequence from 5′

    to 3′

    is 100% complementary to the miRNA sequence,wherein i) the 5′

    terminus of the second polynucleotide is replaced with a lower alkylamine group and/or ii) there are one or more sugar modifications with a 2′

    oxygen-methyl (2′

    O-Me) in the first or last 1 to 6 residues of the second polynucleotide.

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