Dynamic flow imaging phantom and model therefor

• US 8,563,919 B2
• Filed: 05/27/2011
• Issued: 10/22/2013
• Est. Priority Date: 05/28/2010
• Status: Active Grant

• Current Assignee: University Health Network
• Original Assignee: University Health Network
• Inventors: Coolens, Catherine, Keller, Harald, Driscoll, Brandon
• Primary Examiner(s): Porta, David
• Assistant Examiner(s): Jo, Taeho
• Application Number:
  US13/117,764
• Publication Number:
  US 20110293074A1
• Time in Patent Office: 879 Days
• Field of Search: 250/252.1, 434/268, 435/284.1, 378/207
• US Class Current: 250/252.1
• CPC Class Codes: A61B 2017/00716 simulating physical properties
• CPC Class Codes: A61B 2017/00725 Calibration or performance testing
• CPC Class Codes: A61B 6/032 Transmission computed tomography [CT]
• CPC Class Codes: A61B 6/486 involving generating temporal series of image data
• CPC Class Codes: A61B 6/507 for determination of haemodynamic parameters, e.g. perfusion CT
• CPC Class Codes: A61B 6/583 using calibration phantoms
• CPC Class Codes: G09B 23/303 specially adapted to simulate circulation of bodily fluids

Abstract

A phantom for simulation of perfusion, for use in dynamic flow imaging. The phantom includes a first compartment having a first inlet and a first outlet, and a second compartment having a second outlet. The first and the second compartments have fluid communication with each other, to simulate perfusion between the first and the second compartments. The first and the second outlets are separately controllable to adjust outflow of fluid from each compartment and to adjust fluid pressure in each compartment, thereby controlling rates of communication of fluids between the first and the second compartments.

Claims

1. A phantom for simulation of perfusion, for use in dynamic flow imaging, the phantom comprising:

a first compartment having a first inlet and a first outlet, the first inlet being connectable to fluid source for introducing fluid into the phantom;

a second compartment having a second outlet;

wherein the first and the second compartments have fluid communication with each other, to simulate perfusion between the first and the second compartments;

each of the first and the second outlets being separately controllable to adjust outflow of fluid from each compartment and to adjust fluid pressure in each compartment, thereby controlling rates of communication of fluids between the first and the second compartments.

2. The phantom of claim 1 wherein at least a portion of the first compartment is contained in the second compartment.

3. The phantom of claim 2 wherein the first compartment has a plurality of orifices in the portion contained in the second compartment, for fluid communication with the second compartment.

4. The phantom of claim 2 wherein the first compartment is a tube.

5. The phantom of claim 1 wherein the second compartment has a second inlet.

6. The phantom of claim 1 wherein the first and the second compartments have fluid communication with each other at least via a plurality of orifices.

7. The phantom of claim 1 wherein the first and the second compartments have fluid communication with each other at least via a diffusion-based exchange mechanism.

8. The phantom of claim 1 wherein the first and the second compartments have fluid communication with each other at least via a microvascular exchange system.

9. A method of simulating perfusion in dynamic flow imaging using the phantom as defined in claim 1, the method comprising:

determining system parameters for controlling inflow and outflow of the phantom, to mimic a physiological condition;

configuring outlet valves according to the determined system parameters;

introducing a fluid into the phantom according to the determined system parameters; and

imaging output from the phantom.

10. The method of claim 9 wherein the physiological condition is that of a physiological organ.

11. The method of claim 10 wherein the physiological organ is a human liver or a human brain.

12. A system for simulation of perfusion, for use in dynamic flow imaging, the system comprising:

a phantom comprising;

a first compartment having a first inlet and a first outlet, the first inlet being connectable to fluid source for introducing fluid into the phantom;

a second compartment having a second outlet;

wherein the first and the second compartments have fluid communication with each other, to simulate perfusion between the first and the second compartments;

each of the first and the second outlets being separately controllable to adjust outflow of fluid from each compartment and to adiust fluid pressure in each compartment, thereby controlling rates of communication of fluids between the first and the second compartments;

a pump for providing fluid to the phantom;

an injector for providing contrast to the fluid; and

respective valves for controlling outflow from each of the first and the second outlets.