Method and device for defining a beam of high-energy rays

• US 8,565,378 B2
• Filed: 05/05/2010
• Issued: 10/22/2013
• Est. Priority Date: 05/06/2005
• Status: Active Grant

• Current Assignee: Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts
• Original Assignee: Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts
• Inventors: Echner, Gernot
• Primary Examiner(s): SONG, HOON K
• Application Number:
  US12/662,814
• Publication Number:
  US 20100270480A1
• Time in Patent Office: 1,266 Days
• Field of Search: 378/65, 378/64, 378/147, 378/148, 378/149, 378/150
• US Class Current: 378/65
• CPC Class Codes: A61N 5/1036 Leaf sequencing algorithms
• CPC Class Codes: A61N 5/1042 with spatial modulation of the radiation beam within the treatment head

Abstract

The invention relates to a method and device for operating collimator (1) for limiting a beam of high-energy radiation (2) which, starting from an essentially point-shaped radiation source (3), is directed onto an object (4) to be treated and which is used especially for stereotactic, conformal radiation therapy of tumors, wherein the collimator (1) has an iris diaphragm (5) as a beam-limiting means. For such a collimator (1), a high degree of shielding for minimal overall height and with a variable opening size of the diaphragm opening (12) is achieved, in that the iris diaphragm (5) has at least three diaphragm leaves (6, 6′, 6″, or 7, 7′, 7″, 7′″, or 8, 8′, 8″, 8′″, 8″″, or 9, 9′, 9″, 9′″, 9″″, 9′″″) which have touching side surfaces (10) enclosing the same angle (α), wherein the diaphragm leaves (6, 6′, 6″, or 7, 7′, 7″, 7′″, or 8, 8′, 8″, 8′″, 8″″, or 9, 9′, 9″, 9′″, 9″″, 9′″″) open up a beam-limiting opening (12) such that a sliding movement (13) along the side surfaces (10) takes place by a number of diaphragm leaves (6, 6′, 6″, or 7, 7′, 7″, 7′″, or 8, 8′, 8″, 8′″, 8″″, or 9, 9′, 9″, 9′″, 9″″, 9′″″) which is reduced by at most one.

Claims

1. A method for stereotactic, conformal radiation therapy of tumors, the method comprising the steps of:

a) positioning an iris diaphragm collimator to irradiate the tumor from a first irradiation angle, the iris diaphragm having at least three diaphragm leaves, wherein the diaphragm leaves open up a beam-limiting opening such that a sliding movement along side surfaces of the diaphragm leaves takes place by a number of diaphragm leaves which is reduced by at most one;

b) setting a first aperture opening of the collimator suitable for irradiation of a first region of the tumor;

c) irradiating the tumor;

d) translating the collimator in a direction substantially transverse to said first radiation angle to scan the tumor;

e) irradiating a further region of the tumor;

f) repeating steps d) and e) until a desired region of the tumor is irradiated with the first aperture size;

g) setting a further aperture opening of the collimator which differs from the first aperture opening;

h) repeating steps d) through g) until a desired region of the tumor is irradiated;

i) positioning the iris diaphragm collimator to irradiate the tumor from a second irradiation angle which differs from the first irradiation angle; and

j) repeating steps b) through i) until a desired dose of radiation has been applied to the tumor.

2. The method of claim 1, wherein the first aperture opening is larger than the further aperture opening.

3. The method of claim 1, wherein one diaphragm leaf remains stationary during at least one of steps b) and g).

4. The method of claim 3, wherein the first aperture opening has a shape which differs from a shape of the further aperture opening.

5. A device for stereotactic, conformal radiation therapy of tumors, the device comprising:

an iris diaphragm collimator having at least three diaphragm leaves, said diaphragm leaves defining a beam-limiting opening such that a sliding movement along side surfaces of said leaves takes place by a number of diaphragm leaves which is reduced by at most one;

a mechanism for positioning said iris diaphragm collimator to irradiate the tumor from an irradiation angle;

a mechanism for setting an aperture opening of said iris diaphragm collimator suitable for irradiation of a first portion of the tumor;

a mechanism for irradiating the tumor; and

a scanning mechanism for translating said iris diaphragm collimator in a direction substantially transverse to said irradiation angle with said irradiation angle and said aperture opening thereby remaining substantially unchanged, thereby permitting irradiation of a second portion of the tumor which differs from the first portion of the tumor.

6. The device of claim 5, wherein said setting mechanism does not induce displacement of one diaphragm leaf.

7. The device of claim 6, wherein said setting mechanism generates aperture openings of differing shapes.

8. The device of claim 5, wherein said diaphragm leaves have touching side surfaces enclosing a same angle.

9. The device of claim 5, wherein the device comprises a robot arm on which a radiation source and said iris diaphragm collimator are disposed, said robot arm comprising both said positioning mechanism and said scanning mechanism.

10. The device of claim 5, wherein a gantry brings a radiation source and said iris diaphragm collimator into various solid angle alignments of radiation, limited by the iris diaphragm collimator, relative to an object being treated, said gantry comprising said positioning mechanism.

11. The device of claim 5, wherein said iris diaphragm collimator has a shielding capability designed for high-energy radiation from a radiation source in a megavolt range.

12. The device of claim 11, wherein said diaphragm leaves have a thickness between 6 and 10 cm.

13. The device of claim 8, wherein a sliding movement of all diaphragm leaves is effected by equal adjustment paths, so that, after positioning, said opening is formed by sub-regions of said side surfaces that have an equal distance from a center.

14. The device of claim 8, wherein said diaphragm leaves are supported by linear guides running in a direction of sliding movement.

15. The device of claim 5, wherein said iris diaphragm collimator has four diaphragm leaves.

16. The device of claim 15, wherein each side surface forming said opening transitions at an inner end thereof into a tab-like, projecting circular arc forming a quarter circle, so that said four diaphragm leaves can selectively form a round opening or square openings, with rounded corners, of various sizes.

17. The device of claim 5, wherein said iris diaphragm collimator has at least six diaphragm leaves.

18. The device of claim 5, further comprising loading devices that press said side surfaces of said diaphragm leaves against each other.

19. The device of claim 18, wherein said loading devices comprise springs which act on said diaphragm leaves.

20. The device of claim 18, wherein said side surfaces have common guides with side surfaces of adjacent diaphragm leaves being shifted relative to each other in adjacent regions thereof not used for forming said opening.

21. The device of claim 5, wherein sliding movement of said diaphragm leaves is realized such that at least one diaphragm leaf is driven.

22. The device of claim 21, wherein all of the diaphragm leaves are simultaneously driven.

23. The device of claim 22, wherein a drive is provided for each diaphragm leaf with simultaneous movement being realized by an electronic controller.

24. The device of claim 22, wherein one drive simultaneously drives all of diaphragm leaves via a mechanism.

25. The device of claim 24, wherein said mechanism drives diaphragm leaves by means of adjusting cams arranged in a spiral on a cam disk that rotates about a center.

26. The device of claim 24, wherein said mechanism has a regulating element that can rotate about a center to act on each diaphragm leaf via a regulating arm.

27. The device of claim 26, further comprising restoring springs acting against said sliding movement via said regulating arm.

28. The device of claim 5, wherein touching side surfaces of said diaphragm leaves define tolerance dependent gaps which are not parallel to a beam path.

29. The device of claim 28, wherein said side surfaces have non-planar structures which engage in complementary fashion in a sliding direction.

30. The device of claim 28, wherein said iris diaphragm collimator is tilted relative to an imaginary diaphragm plane lying perpendicular to an optical axis, such that a beam can no longer pass through said gaps.

31. The device of claim 5, further comprising a fixed diaphragm for additional shielding located in a beam path outside of said iris diaphragm collimator, said fixed diaphragm having an opening which is adjusted to a greatest possible opening of said iris diaphragm collimator.

32. A device for stereotactic, conformal radiation therapy of tumors, the device comprising:

means for positioning an iris diaphragm collimator to irradiate the tumor from a first irradiation angle, the iris diaphragm having at least three diaphragm leaves, wherein the diaphragm leaves open up a beam-limiting opening such that a sliding movement along side surfaces of the diaphragm leaves takes place by a number of diaphragm leaves which is reduced by at most one;

means for setting a first aperture opening of the collimator suitable for irradiation of a first portion of the tumor at said first irradiation angle;

means for irradiating the first portion of the tumor at said first irradiation angle;

means for translating the collimator in a direction substantially transverse to said first irradiation angle to scan a second portion of the tumor at said first irradiation angle using said first aperture opening, wherein the second portion of the tumor differs from the first portion of the tumor;

means for irradiating the second portion of the tumor;

means for a setting a second aperture opening of the collimator which differs from the first aperture opening;

means for irradiating a third portion of the tumor using the second aperture opening, wherein the third portion of the tumor differs from both the first and second portions of the tumor; and

means for positioning the iris diaphragm collimator to irradiate the tumor from a second irradiation angle which differs from the first irradiation angle.