Method and device for monitoring acute decompensated heart failure

• US 8,565,866 B2
• Filed: 12/21/2007
• Issued: 10/22/2013
• Est. Priority Date: 12/21/2007
• Status: Active Grant

• Current Assignee: St. Jude Medical AB (Abbott Laboratories Incorporated)
• Original Assignee: St. Jude Medical AB (Abbott Laboratories Incorporated)
• Inventors: Blomqvist, Andreas, Holmstrm, Nils, Hedberg, Sven-Erik, hlander, Malin
• Primary Examiner(s): STOKLOSA, JOSEPH A
• Application Number:
  US12/809,255
• Publication Number:
  US 20110144508A1
• Time in Patent Office: 2,132 Days
• Field of Search: 600/506, 600/547
• US Class Current: 600/547
• CPC Class Codes: A61B 5/0245 by using sensing means generating electric signals, i.e. ECG signals
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle

Abstract

An implantable medical device has an impedance determiner for determining a cardiogenic impedance signal based on electric signals sensed by connected electrodes. A parameter calculator processes the impedance signal to calculate an impedance parameter representative of the cardiogenic impedance in connection with the diastolic phase of a heart cycle. This parameter is then employed by the device for monitoring acute decompensated heart failure status of a subject.

Claims

1. An implantable medical device comprising:

an electrode connecting arrangement connectable to at least two electrodes;

an impedance determiner that determines an impedance signal associated with a heart of a subject over at least a diastolic phase of a heart beat based on electric signals sensed by said at least two electrodes;

a signal analyzer configured to identify a global maximum in said impedance signal during said heart beat, and to identify first local maximum in said impedance signal during the diastolic phase following the identified global maximum in the impedance signal;

a parameter calculator that calculates, based on said impedance signal, an impedance parameter by applying a non-zero first weight to a diastolic portion of said impedance signal corresponding to a portion of said diastolic phase immediately preceding said identified first local maximum and up to directly following said identified first local maximum and applying a second weight to a non-diastolic portion of said impedance signal corresponding to a non-diastolic phase of said heart beat, said first weight being larger than said second weight; and

an acute decompensated heart failure, ADHF, monitor that monitors an ADHF status based on said impedance parameter.

2. The implantable medical device according to claim 1, wherein said electrode connecting arrangement is connectable to at least one implantable electric lead comprising said at least two electrodes and is attachable to said heart.

3. The implantable medical device according to claim 1, wherein said parameter calculator calculates, based on said impedance signal, a diastolic impedance parameter representative of said impedance associated with said heart during at least a portion of said diastolic phase.

4. The implantable medical device according to claim 1, wherein said parameter calculator performs an isolated impedance analysis of said impedance signal during said at least a portion of said diastolic phase to calculate said impedance parameter.

5. The implantable medical device according to claim 1, wherein said second weight is zero.

6. The implantable medical device according to claim 1, wherein said impedance determiner determines said impedance signal as an average of multiple cardiogenic impedances measured during different heart beats.

7. The implantable medical device according to claim 1, further comprising:

a signal applier that applies, through said at least two electrodes,

a current signal or a voltage signal to at least a portion of said heart during at least said diastolic phase of said heart beat; and

a signal measurer that measures a resulting voltage signal or a resulting current signal sensed by said at least two electrodes over at least a portion of said heart during at least said diastolic phase of said heart beat, said impedance determiner calculating said impedance signal based on said current signal and said resulting voltage signal or said voltage signal and said resulting current signal.

8. The implantable medical device according to claim 1, wherein said parameter calculator is calculates, based on said impedance signal, said impedance parameter by applying said non-zero first weight to a diastolic portion of said impedance signal corresponding to the portion of said diastolic phase following closure of the aortic valve up to atrial contraction and applying said second weight to said non-diastolic portion of said impedance signal.

9. The implantable medical device according to claim 1, wherein said parameter calculator calculates, based on said impedance signal, said impedance parameter by applying said non-zero first weight to a diastolic portion of said impedance signal corresponding to the portion of said diastolic phase consisting of isometric relaxation and rapid filling of the ventricles of said heart and applying said second weight to said non-diastolic portion of said impedance signal.

10. The implantable medical device according to claim 1, wherein said parameter calculator calculates said impedance parameter as representative of a time difference between the occurrence of said global maximum and said first local maximum.

11. The implantable medical device according to claim 1, wherein said parameter calculator calculates said impedance parameter as representative of an amplitude difference between said global maximum and said first local maximum.

12. The implantable medical device according to claim 1, further comprising:

an electrocardiogram calculator determines an electrocardiogram signal based on electric signals collected by an electrode of said at least two electrodes; and

a signal analyzer that determines, based on said electrocardiogram signal, a timing of a QRS complex during said heart beat.

13. The implantable medical device according to claim 1, further comprising a signal analyzer that determines, based on said impedance signal, a timing of a QRS complex during said heart beat.

14. The implantable medical device according to claim 12, wherein said parameter calculator calculates, based on said impedance signal, said impedance parameter by applying said non-zero first weight to a diastolic portion of said impedance signal corresponding to the portion of said diastolic phase starting about 400 ms from said timing of said QRS complex and applying said second weight to said non-diastolic portion of said impedance signal.

15. The implantable medical device according to claim 1, wherein said parameter calculator calculates said impedance parameter as representative of an area under an impedance curve obtained from said impedance signal, during said at least a portion of said diastolic phase.

16. The implantable medical device according to claim 1, wherein said parameter calculator calculates said impedance parameter as representative of a length of an impedance curve obtained from said impedance signal, during said at least a portion of said diastolic phase.

17. The implantable medical device according to claim 1, wherein said ADHF monitor comprises and an ADHF detector that detects ADHF based on said impedance parameter.

18. The implantable medical device according to claim 17, wherein said ADHF detector detects ADHF based on a comparison of said impedance parameter with a reference parameter.

19. The implantable medical device according to claim 18, wherein said parameter calculator calculates said reference parameter, based on a previously determined impedance signal, by applying said non-zero first weight to a diastolic portion of said previously determined impedance signal corresponding to at least a portion of said diastolic phase during a previous heart beat and applying said second weight to a non-diastolic portion of said previously determined impedance signal corresponding to a non-diastolic phase of said previous heart beat.

20. The implantable medical device according to claim 18, wherein said ADHF detector compares said impedance parameter with said reference parameter, and detects ADHF when a difference between said impedance parameter and said reference parameter exceeds a threshold.

21. The implantable medical device according to claim 20, further comprising a parameter updater that updates said reference parameter when said difference between said impedance parameter and said reference parameter does not exceed said threshold.

22. The implantable medical device according to claim 1, wherein said ADHF monitor monitors a recovery status from an ADHF event based on said impedance parameter.

23. An implantable medical device as claimed in claim 12 further comprising a signal analyzer that identifies a first local maximum in said impedance signal in said diastolic phase, and wherein said parameter calculator calculates said impedance parameter as representative of a time difference between occurrence of said QRS complex and said first local maximum.

24. An implantable medical device as claimed in claim 13 further comprising a signal analyzer that identifies a first local maximum in said impedance signal in said diastolic phase, and wherein said parameter calculator calculates said impedance parameter as representative of a time difference between occurrence of said QRS complex and said first local maximum.