Systems and methods for monitoring health and delivering drugs transdermally
First Claim
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1. A transdermal sampling system, comprising:
- a substrate including;
at least one capillary formed therein, the capillary having a first end with a microablation heater associated therewith, the microablation heater including a conductive serpentine pathway connected to electrodes for generating current therein, wherein the microablation heater is configured to ablate an individual confined volume of the stratum corneum of a subject'"'"'s skin in order to access interstitial fluid from the epidermis; and
a detection system formed on the substrate and located at a second end of the at least one capillary for receiving the accessed interstitial fluid from the at least one capillary and analyzing the interstitial fluid to detect one or more analytes of interest;
wherein a length of the at least one capillary is perpendicular to a skin contact surface of the substrate.
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Abstract
The present invention pertains to a system and method for transdermal sampling, comprising: at least one sampler for retrieving and transferring at least one analyte obtained transdermally from the skin of a subject; at least one detector system for identifying and quantifying said at least one analyte; and at least one logic module for (i) receiving and storing input data from said at least one detector, (ii) relating the input data to other data obtained from the subject, (iii) displaying output information, (iv) transmitting the output information to another system, and (v) controlling the operation of said at least one sampler and at least one detector.
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Citations
25 Claims
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1. A transdermal sampling system, comprising:
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a substrate including; at least one capillary formed therein, the capillary having a first end with a microablation heater associated therewith, the microablation heater including a conductive serpentine pathway connected to electrodes for generating current therein, wherein the microablation heater is configured to ablate an individual confined volume of the stratum corneum of a subject'"'"'s skin in order to access interstitial fluid from the epidermis; and a detection system formed on the substrate and located at a second end of the at least one capillary for receiving the accessed interstitial fluid from the at least one capillary and analyzing the interstitial fluid to detect one or more analytes of interest; wherein a length of the at least one capillary is perpendicular to a skin contact surface of the substrate. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A transdermal sampling system, comprising:
a substrate including; multiple capillaries formed therein, each of the multiple capillaries having a first end associated with a microablation heater, each microablation heater including electrodes for generating current therein, wherein each microablation heater is configured to ablate an individual confined volume of the stratum corneum of a subject'"'"'s skin at separate times in order to access interstitial fluid from the epidermis; and a detection system formed on the substrate at a second end of each of the multiple capillaries for receiving the accessed interstitial fluid from each of the multiple capillaries at separate times and analyzing the interstitial fluid from each of the independent confined volumes of the stratum corneum to detect one or more analytes of interest, wherein a length of each of the multiple capillaries is perpendicular to a skin contact surface of the substrate. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15)
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16. A transdermal sampling system, comprising:
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a first substrate including; an array of capillaries formed therein, each capillary includes a first end and second end thereof; an individual microablation heater associated with a first end of each capillary, each microablation heater including electrodes for generating current therein, wherein each microablation heater is configured to ablate an individual confined volume of the stratum corneum of a subject'"'"'s skin in order to access interstitial fluid from the epidermis; and a detection system formed on the substrate at a second end of each capillary for receiving the accessed interstitial fluid from each capillary at separate times and analyzing separately the interstitial fluid from each of the independent confined volumes of the stratum corneum received from a corresponding capillary in the array to detect one or more analytes of interest; wherein a length of each of the capillaries is perpendicular to a skin contact surface of the substrate; a second substrate including at least a logic module and associated circuitry, wherein the logic module and associated circuitry is configured to control each of the microablation heaters and the detection system; and further wherein the first substrate is removably connected to the second substrate and is replaceable with a third identical substrate. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25)
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Specification