Clotting cascade initiating apparatus and methods of use and methods of closing wounds

• US 8,568,448 B2
• Filed: 12/21/2012
• Issued: 10/29/2013
• Est. Priority Date: 12/16/1997
• Status: Expired due to Fees

• Current Assignee: St. Croix Surgical Systems, LLC
• Original Assignee: Closys Corporation
• Inventors: Nowakowski, Karol L
• Primary Examiner(s): Dornbusch, Dianne
• Application Number:
  US13/724,520
• Publication Number:
  US 20130110160A1
• Time in Patent Office: 312 Days
• Field of Search: 606/213, 606/214, 606/232, 424/424, 424/425, 424/423, 424/520, 424/529, 128/898
• US Class Current: 606/214
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 17/0057 Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect sutures A61B17/04; closing rectum or urethra near body surface A61F2/0009
• CPC Class Codes: A61B 2017/00637 for sealing trocar wounds through abdominal wall
• CPC Class Codes: A61B 2017/00641 for closing fistulae, e.g. anorectal fistulae
• CPC Class Codes: A61B 2017/0065 the implement being an adhesive
• CPC Class Codes: A61L 24/0005 Ingredients of undetermined constitution or reaction products thereof
• CPC Class Codes: A61M 2025/0681 Systems with catheter and outer tubing, e.g. sheath, sleeve or guide tube
• CPC Class Codes: A61M 25/0662 Guide tubes

Abstract

Wound closure methods and apparatuses are provided which utilize blood fluid by activating the clotting cascade of the blood fluid outside the body within a substantially enclosed sterile container then introducing the blood fluid to the wound site. Methods and apparatuses for providing ways of inhibiting anticoagulants and slowing fibrin clot degradation are also disclosed. Kits for practicing the invention singularly or in combination with and/or associated with preferred procedures are also disclosed.

Claims

1. A method of treating a subcutaneous blood vessel wound in a patient comprising establishing a subcutaneous mass proximate the wound, wherein the mass comprises whole blood and cross-linked polymer distributed throughout the mass, and wherein polymerization of the polymer occurs outside the patient prior to the establishing.

2. The method of claim 1 wherein the cross-linked polymer is formed prior to the establishing.

3. The method of claim 1 wherein the mass is in the form of a gel.

4. The method of claim 1 wherein the cross-linked polymer is homogeneously distributed throughout the mass.

5. The method of claim 1 wherein the mass is established about a surface of a blood vessel comprising the wound.

6. The method of claim 1 wherein the mass is established within a subcutaneous space proximate the wound.

7. The method of claim 1 wherein the wound is an arterial wound.

8. The method of claim 1 wherein the cross-linked polymer is biodegradable.

9. The method of claim 1 wherein the mass comprises blood previously exposed to an anticoagulant.

10. The method of claim 1 wherein the blood vessel wound is on a blood vessel comprising anticoagulated blood.

11. The method of claim 1 wherein the cross-linked polymer is comprised of a determinate amount of polymer components obtained prior to the establishing and stored outside the patient prior to the establishing.

12. A method of treating a subcutaneous blood vessel wound in a patient comprising establishing a substantially blood-based mass proximate the wound, wherein the substantially blood-based mass comprises a cross-linked polymer comprising a determinate amount of polymer components obtained prior to the establishing and stored outside the patient prior to the establishing, and wherein the substantially blood-based mass comprises whole blood.

13. The method of claim 12 wherein the cross-linked polymer is formed prior to the establishing.

14. The method of claim 12 wherein the mass is in the form of a gel.

15. The method of claim 12 wherein the cross-linked polymer is homogeneously distributed throughout the mass.

16. The method of claim 12 wherein the mass comprises whole blood distributed throughout the mass.

17. The method of claim 12 wherein the mass is established about a surface of a blood vessel comprising the wound.

18. The method of claim 12 wherein the mass is established within a subcutaneous space proximate the wound.

19. The method of claim 12 wherein the wound is an arterial wound.

20. The method of claim 12 wherein the cross-linked polymer is biodegradable.

21. The method of claim 12 wherein the mass comprises blood previously exposed to an anticoagulant.

22. The method of claim 12 wherein the blood vessel wound is on a blood vessel comprising anticoagulated blood.