Preconcentrator for analysis instruments

• US 8,569,691 B2
• Filed: 11/23/2010
• Issued: 10/29/2013
• Est. Priority Date: 11/24/2009
• Status: Active Grant

• Current Assignee: University of Louisville Research Foundation
• Original Assignee: University of Louisville Research Foundation
• Inventors: Cambron, Scott, Roussel, Thomas J., Keynton, Robert S.
• Primary Examiner(s): IPPOLITO, NICOLE MARIE
• Application Number:
  US12/953,108
• Publication Number:
  US 20120132798A1
• Time in Patent Office: 1,071 Days
• Field of Search: 250/281, 250/282, 250/288
• US Class Current: 250/288
• CPC Class Codes: G01N 1/405 by adsorption or absorption
• CPC Class Codes: G01N 30/08 using an enricher

Abstract

An interchangeable preconcentrator assembly for delivering an analyte to an analysis instrument. The assembly includes a housing defining an inner chamber. An inlet is in fluid communication with the inner chamber, an outlet is in fluid communication with the inner chamber for delivering fluid to the inlet of the analysis instrument, and an exhaust outlet is in fluid communication with the inner chamber. A plurality of removable preconcentrator packages are disposed within the inner chamber. Each of the removable preconcentrator packages including a microscale preconcentrator. A fluid flow path is defined between the inlet and the inner chamber. A first fluid flow path is defined between the preconcentrators and the exhaust outlet, and a second fluid flow path is defined between the preconcentrators and the outlet. A selectably operable valve directs fluid flow from the inner chamber into either the first fluid flow path or the second fluid flow path.

Claims

1. An interchangeable preconcentrator assembly for delivering an analyte to an inlet of an analysis instrument comprising:

a housing defining an inner chamber;

an inlet in fluid communication with the inner chamber;

an outlet in fluid communication with the inner chamber for delivering fluid to the analysis instrument;

an exhaust outlet in fluid communication with the inner chamber;

a plurality of removable preconcentrator packages disposed within the inner chamber, each of said removable preconcentrator packages including a microscale preconcentrator, wherein a fluid flow path is defined between the inlet and the inner chamber;

the assembly further defining a first fluid flow path between the preconcentrators and said exhaust outlet and a second fluid flow path between the preconcentrators and said outlet; and

a selectably operable valve for selectively directing fluid flow from the inner chamber into either the first fluid flow path or the second fluid flow path;

wherein said plurality of removable preconcentrator packages are urged against a surface of said housing by a mechanically biased urging member.

2. The assembly of claim 1, wherein the fluid flow path to the chamber is also defined through said biased urging member.

3. The assembly of claim 2, wherein said mechanically biased urging member comprises:

a plunger including an at least partially open tube defining a space, said plunger including an engaging surface adjacent to said space.

4. The assembly of claim 3, further comprising:

a biasing member for mechanically biasing said mechanically biased urging member toward the surface of said inner housing.

5. The assembly of claim 4, wherein said biasing member comprises a spring.

6. The assembly of claim 1,

wherein the preconcentrator comprises a microscale preconcentrator chip including a substrate having a surface and a heater for heating the surface;

wherein each of said preconcentrator packages further comprises;

first and second plates at least partially enclosing said chip, said first plate having an opening aligned longitudinally with the surface of the preconcentrator chip for allowing fluid flow to said preconcentrator chip; and

at least one electrode coupled to said heater and extending beyond said first and second plates.

7. The assembly of claim 6, wherein each of said at least one preconcentrator package further comprises:

a flex circuit having said at least one electrode provided thereon and coupled to said heater.

8. The assembly of claim 1, wherein said selectively operable valve comprises a sleeve valve and a sleeve.

9. The assembly of claim 8, further comprising:

a motor for selectively operating said valve.

10. The assembly of claim 9, wherein said motor comprises a stepper motor, and wherein said housing includes a portion for accommodating said stepper motor.

11. The assembly of claim 10, wherein said housing further comprises a valve housing block, said valve housing block comprising a plate having a seat for accommodating said sleeve, a wheel of said stepper motor, and a coupling between said sleeve and said stepper motor.

12. The assembly of claim 8, further comprising:

a fluid flow inducing device in fluid communication with the exhaust outlet.

13. The assembly of claim 12, wherein said fluid flow inducing device comprises a low power fan.

14. The assembly of claim 13, wherein the low power fan is disposed within a shroud.

15. The assembly of claim 12

wherein said fluid flow inducing device is disposed within a lower housing portion of said housing;

wherein said lower housing portion includes said exhaust outlet for fluid egress from said housing.

16. The assembly of claim 1, wherein the analysis instrument comprises a detector.

17. The assembly of claim 16, wherein the detector comprises an ion mobility spectrometer (IMS).

18. An interchangeable preconcentrator assembly for delivering analyte to an analysis instrument comprising:

housing means for defining a chamber, an inlet to the chamber, a first fluid flow path leading away from the analysis instrument, and a second fluid flow path leading to the analysis instrument;

means for accommodating at least one preconcentrator chip disposed within chamber;

means for selectively directing fluid flow from the chamber to either the first fluid flow path or the second fluid flow path; and

means for mechanically biasing said at least one preconcentrator chip toward a surface of said housing means;

wherein said means for accommodating comprise first and second plates at least partially enclosing said chip, said first plate having an opening for allowing fluid flow to said preconcentrator chip.

19. A method for preconcentrating an analyte in fluid/air and selectively delivering the preconcentrated analyte to an analysis instrument, the method comprising:

delivering the fluid/air containing the analyte to a plurality of micropreconcentrators disposed within an inner chamber defined by a housing and urged against a surface of said housing by a mechanically biased urging member, while a valve seals the inner chamber from a second fluid flow path in the housing leading to the analysis instrument to permit a first fluid flow path from the inner chamber away from the analysis instrument;

heating the micropreconcentrators; and

selectively operating the valve to permit the first fluid flow path and close the second fluid flow path.

20. The method of claim 19, further comprising:

during said delivering, actuating a fluid flow inducing device disposed within said first fluid flow path.