Intensity modulated three-dimensional radiation scanning method and apparatus

• US 8,569,717 B2
• Filed: 02/24/2010
• Issued: 10/29/2013
• Est. Priority Date: 05/22/2008
• Status: Active Grant

• Current Assignee: Andrey Vladimirovich Balakin, Pavel Vladimirovich Balakin
• Original Assignee: Vladimir Balakin
• Inventors: Balakin, Vladimir
• Primary Examiner(s): SMYTH, ANDREW P
• Application Number:
  US12/711,609
• Publication Number:
  US 20100171447A1
• Time in Patent Office: 1,343 Days
• Field of Search: None
• US Class Current: 250/492.1
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 5/10 X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy A61N5/01 takes precedence
• CPC Class Codes: A61N 5/1043 Scanning the radiation beam, e.g. spot scanning or raster scanning
• CPC Class Codes: H05H 13/04 Synchrotrons
• CPC Class Codes: H05H 7/10 Arrangements for ejecting particles from orbits

Abstract

The invention relates to treatment of solid cancers and more particularly to a method and apparatus correlating proton beam intensity with proton delivery efficiency, optionally in a raster beam scanning system. The system induces betatron oscillation on the proton beam causing the beam to traverse an extraction material resulting in slowed protons and a feedback current proportional to the proton flux. A controller receives the desired intensity from an irradiation plan and the feedback current and adjusts the radio-frequency field in the radio-frequency cavity system to yield an intensity of the proton beam that matches the desired intensity from the irradiation plan. Preferably, the intensity of the proton beam correlates with radiation delivery efficiency. The system preferably operates in conjunction with a multi-field charged particle cancer therapy system, with charged particle beam injection, particle beam acceleration, multi-axis charged particle beam control, and/or targeting methods and apparatus.

Claims

1. An apparatus configured to control a charged particle beam for irradiation of a tumor of a patient, comprising:

a synchrotron configured with an extraction foil, wherein a timing controller times the charged particle beam striking said extraction foil in an acceleration period in said synchrotron resulting in extraction of the charged particle beam at a selected energy;

a raster beam scanning system configured to scan the charged particle beam across delivery positions while both (1) delivering the charged particle beam at and between the delivery positions and (2) simultaneously varying said selected energy level of the charged particle beam across the delivery positions, wherein said control of said selected energy further comprises use of readings from a magnetic sensor, said magnetic sensor proximate a bending magnet in said synchrotron; and

a feedback system, wherein said feedback system stabilizes a magnetic field in said bending magnet using input from said magnetic sensor to control a correction coil operating at less than ten percent the power of a winding coil, both said correction coil and said winding coil wound around said bending magnet.

11. The apparatus of claim 1, wherein said control of said selected energy further comprises control of an accelerator system in said synchrotron, said accelerator system comprising:

a set of at least ten coils;

a set of at least ten wire loops;

a set of at least ten microcircuits, each of said microcircuits integrated to one of said loops, wherein each of said loops completes at least one turn about at least one of said coils; and

a radio-frequency synthesizer sending a low voltage signal to each of said microcircuits, each of said microcircuits amplifying said low voltage signal yielding an acceleration voltage.

2. An apparatus configured to control a charged particle beam for irradiation of a tumor of a patient, comprising:

a synchrotron configured with an extraction foil, wherein a timing controller times the charged particle beam striking said extraction foil in an acceleration period in said synchrotron resulting in extraction of the charged particle beam at a selected energy;

a raster beam scanning system configured to scan the charged particle beam across delivery positions while both (1) delivering the charged particle beam at and between the delivery positions and (2) simultaneously varying said selected energy level of the charged particle beam across the delivery positions; and

an intensity controller configured to measure a current resulting from the charged particle beam striking said extraction foil, said current used as a feedback control to a radio-frequency cavity system, wherein an applied radio frequency, using said feedback control, in said radio-frequency cavity system controls the number of particles in the charged particle beam striking said extraction foil resulting in intensity control of the charged particle beam.

3. The apparatus of claim 2, wherein said radio-frequency cavity system comprises:

a first pair of blades; and

a second pair of blades,

wherein the applied radio-frequency applied across said first pair of blades alters trajectory of the charged particle beam through said extraction foil yielding a reduced energy charged particle beam, wherein the reduced energy charged particle beam passes through said second pair of blades, wherein a direct current voltage of at least five hundred volts applied across said second pair of blades and an extraction magnet combine to extract the reduced energy charged particle beam out of said synchrotron.

4. The apparatus of claim 3, wherein said extraction foil comprises a thickness of about thirty to one-hundred microns, said extraction foil consisting essentially of atoms having six or fewer protons.

5. The apparatus of claim 3, further comprising a velocity controller configured to change a rate of movement of the charged particle beam between the delivery positions along x- and/or y-axes in the tumor as a function of time.

6. The apparatus of claim 5, further comprising:

a rotatable platform configured to hold the patient and to rotate through about three hundred sixty degrees during an irradiation period of the patient,

wherein said velocity controller changes said rate of movement of the charged particle beam to at least four distinct velocities during rotation of said rotatable platform in said irradiation period,

wherein timing of said selected energy and said intensity control occurs in greater than four rotation positions of said rotatable platform during said irradiation period.

7. The apparatus of claim 2, further comprising:

a rotatable platform configured to hold the patient and to rotate through at least one hundred eighty degrees during an irradiation period of the patient,

wherein timing of said selected energy and said intensity control occurs in greater than four rotation positions of said rotatable platform during said irradiation period.

8. The apparatus of claim 7, said rotatable platform configured to hold the patient, wherein the charged particles are delivered from said synchrotron to the tumor of the patient during rotation of the patient on said rotatable platform, wherein ingress energy of the charged particles is distributed to at least ten areas about an outer perimeter of the tumor.

9. The apparatus of claim 7, further comprising:

a respiration sensor generating a respiration signal, said respiration signal corresponding to a respiration cycle of the patient, wherein said timing controller uses said respiration signal to time delivery of the charged particles over a set time period relative to a point in said respiration cycle.

10. The apparatus of claim 9, wherein for at least four rotation positions of said rotatable platform said apparatus comprises independent control of all of:

a horizontal position of the charged particle beam;

a vertical position of the charged particle beam;

said selected energy of the charged particle beam;

said intensity control of the charged particle beam;

said velocity of the charged particle beam; and

said delivery of the charged particle beam over said set time period relative to a point in said respiration cycle.

12. A method for controlling a charged particle beam for irradiation of a tumor of a patient, comprising the steps of:

a timing controller timing a synchrotron configured with an extraction foil, said timing controller timing the charged particle beam to strike said extraction foil in an acceleration period in said synchrotron resulting in extraction of the charged particle beam at a selected energy;

a raster beam scanning system scanning the charged particle beam across delivery positions while both (1) delivering the charged particle beam at and between the delivery positions and (2) simultaneously varying said selected energy level of the charged particle beam across the delivery positions;

an intensity controller measuring a current resulting from the charged particle beam striking said extraction foil, said current used as a feedback control to a radio-frequency cavity system; and

controlling an applied radio frequency, using said feedback control, in said radio-frequency cavity system to control the number of particles in the charged particle beam striking said extraction foil resulting in intensity control of the charged particle beam.

13. The method of claim 12, further comprising the step of:

a velocity controller changing a rate of movement of the charged particle beam between the delivery positions along x- and/or y-axes in the tumor as a function of time.

14. The method of claim 13, further comprising the step of:

a rotatable platform both holding the patient and rotating through about three hundred sixty degrees during an irradiation period of the patient,

wherein said velocity controller changes said rate of movement of the charged particle beam to at least four distinct velocities during rotation of said rotatable platform in said irradiation period,

wherein timing of said selected energy and said intensity control occurs in greater than four rotation positions of said rotatable platform during said irradiation period.

15. The method of claim 14, further comprising the step of:

delivering the charged particle beam from said synchrotron to the tumor of the patient during rotation of the patient on said rotatable platform, wherein ingress energy of the charged particle beam is distributed to at least ten areas about an outer perimeter of the tumor.

16. The method of claim 14, further comprising the steps of:

a respiration sensor generating a respiration signal, said respiration signal corresponding to a respiration cycle of the patient;

said timing controller using said respiration signal to time delivery of the charged particle beam over a set time period relative to a point in said respiration cycle.

17. The method of claim 16, wherein for at least four rotation positions of said rotatable platform said method comprises independent control of all of:

a horizontal position of the charged particle beam;

a vertical position of the charged particle beam;

said selected energy of the charged particle beam;

said intensity control of the charged particle beam;

said velocity of the charged particle beam; and

said delivery of the charged particle beam over said set time period relative to a point in said respiration cycle.