Flowometry in optical coherence tomography for analyte level estimation
First Claim
1. A method of determining blood analyte levels in a tissue sample using optical coherence tomography (OCT), comprising:
- scanning a plurality of regions in the tissue sample using OCT to provide corresponding intensity data measurement;
analyzing the intensity data measurements to determine an indication of blood flow in the corresponding region by at least;
passing the intensity data measurements through a narrow band filter to produce a first output;
passing the intensity data measurements through a wide band filter to produce a second output; and
comparing the first and second outputs to determine the indication of blood flow; and
obtaining blood analyte levels from at least one of the regions having a positive indication of blood flow present as analyzed from OCT measurements.
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Abstract
Optical coherence tomography (herein “OCT”) based analyte monitoring systems are disclosed. In one aspect, techniques are disclosed that can identify fluid flow in vivo (e.g., blood flow), which can act as a metric for gauging the extent of blood perfusion in tissue. For instance, if OCT is to be used to estimate the level of an analyte (e.g., glucose) in tissue, a measure of the extent of blood flow can potentially indicate the presence of an analyte correlating region, which would be suitable for analyte level estimation with OCT. Another aspect is related to systems and methods for scanning multiple regions. An optical beam is moved across the surface of the tissue in two distinct manners. The first can be a coarse scan, moving the beam to provide distinct scanning positions on the skin. The second can be a fine scan where the beam is applied for more detailed analysis.
926 Citations
12 Claims
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1. A method of determining blood analyte levels in a tissue sample using optical coherence tomography (OCT), comprising:
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scanning a plurality of regions in the tissue sample using OCT to provide corresponding intensity data measurement; analyzing the intensity data measurements to determine an indication of blood flow in the corresponding region by at least; passing the intensity data measurements through a narrow band filter to produce a first output; passing the intensity data measurements through a wide band filter to produce a second output; and comparing the first and second outputs to determine the indication of blood flow; and obtaining blood analyte levels from at least one of the regions having a positive indication of blood flow present as analyzed from OCT measurements. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method for determining the presence of fluid flow in a tissue sample using optical coherence tomography, comprising:
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scanning a region in the tissue sample using OCT to provide fringe-modulated intensity data measurements; and using amplitude modulation in the fringe-modulated intensity data measurements to determine whether fluid flow is present in the region by at least; passing the intensity data measurements through a narrow band filter to produce a first output; passing the intensity data measurements through a wide band filter to produce a second output; comparing the first and second outputs.
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Specification