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Adaptive calibration system for spectrophotometric measurements

  • US 8,571,618 B1
  • Filed: 09/27/2010
  • Issued: 10/29/2013
  • Est. Priority Date: 09/28/2009
  • Status: Active Grant
First Claim
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1. A device capable of producing a signal responsive to light attenuated by tissue at a measurement site, the device comprising:

  • an optical sensor configured to emit light on tissue of a living person, detect the light after attenuation by the tissue, and output a signal responsive to the attenuated light; and

    a processor configured to;

    receive the signal from the optical sensor;

    process the signal with a measurement algorithm to determine a first measurement of a physiological parameter, wherein the physiological parameter is glucose, and wherein the measurement algorithm comprises a plurality of basis functions and associated weights, wherein the measurement algorithm is configured to apply a combination of the basis functions and the weights to the signal to determine the first measurement,receive a second measurement of the physiological parameter from an alternative source, the second measurement being an invasive or minimally-invasive glucose measurement, andadaptively adjust the measurement algorithm based at least partly on the second measurement by adapting the weights of the measurement algorithm.

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