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Implantable medical device with chemical sensor and related methods

  • US 8,571,659 B2
  • Filed: 01/27/2012
  • Issued: 10/29/2013
  • Est. Priority Date: 05/17/2006
  • Status: Active Grant
First Claim
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1. A method for providing cardiac arrhythmia therapy to a patient comprising:

  • optically measuring a physiological concentration of an ion in a bodily fluid of the patient with chronically implanted chemical sensor, the chemical sensor comprisinga sensing element comprising a potassium ion selective complexing moiety, the potassium ion selective complexing moiety selected from the group comprising cryptands, crown ethers, bis-crown ethers, calixarenes, noncyclic amides, and hemispherands;

    an excitation assembly configured to illuminate the sensing element;

    a detection assembly configured to receive light from the sensing element;

    an opaque cover layer disposed over a side of the sensing element; and

    a battery in communication with the excitation assembly, wherein all components of the chemical sensor are implanted within the patient;

    transmitting data regarding the physiological concentration of the ion to an implanted pulse generator;

    measuring temperature with an implanted temperature sensor;

    calculating a compensated physiological concentration measurement of the ion using the measured temperature and the transmitted data regarding the physiological concentration of the ion;

    storing the compensated physiological concentration measurement of the ion with an associated time stamp in a memory of the implanted pulse generator; and

    delivering cardiac arrhythmia therapy from the implanted pulse generator to the patient based in part on the compensated physiological concentration of the ion.

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