Implantable medical device with chemical sensor and related methods
First Claim
1. A method for providing cardiac arrhythmia therapy to a patient comprising:
- optically measuring a physiological concentration of an ion in a bodily fluid of the patient with chronically implanted chemical sensor, the chemical sensor comprisinga sensing element comprising a potassium ion selective complexing moiety, the potassium ion selective complexing moiety selected from the group comprising cryptands, crown ethers, bis-crown ethers, calixarenes, noncyclic amides, and hemispherands;
an excitation assembly configured to illuminate the sensing element;
a detection assembly configured to receive light from the sensing element;
an opaque cover layer disposed over a side of the sensing element; and
a battery in communication with the excitation assembly, wherein all components of the chemical sensor are implanted within the patient;
transmitting data regarding the physiological concentration of the ion to an implanted pulse generator;
measuring temperature with an implanted temperature sensor;
calculating a compensated physiological concentration measurement of the ion using the measured temperature and the transmitted data regarding the physiological concentration of the ion;
storing the compensated physiological concentration measurement of the ion with an associated time stamp in a memory of the implanted pulse generator; and
delivering cardiac arrhythmia therapy from the implanted pulse generator to the patient based in part on the compensated physiological concentration of the ion.
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Abstract
In an embodiment, the invention includes an implantable medical device with a pulse generator and a chemical sensor in communication with the pulse generator, the chemical sensor configured to detect an ion concentration in a bodily fluid. In an embodiment, the invention includes a method for providing cardiac arrhythmia therapy to a patient including sensing a physiological concentration of an analyte, communicating data regarding the physiological concentration of the analyte to an implanted pulse generator, and delivering therapy to the patient based in part on the physiological concentration of the ion. In an embodiment, the invention includes a method for monitoring diuretic therapy. In an embodiment, the invention includes a method for controlling delivery of an active agent into a human body. Other aspects and embodiments are provided herein.
166 Citations
11 Claims
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1. A method for providing cardiac arrhythmia therapy to a patient comprising:
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optically measuring a physiological concentration of an ion in a bodily fluid of the patient with chronically implanted chemical sensor, the chemical sensor comprising a sensing element comprising a potassium ion selective complexing moiety, the potassium ion selective complexing moiety selected from the group comprising cryptands, crown ethers, bis-crown ethers, calixarenes, noncyclic amides, and hemispherands; an excitation assembly configured to illuminate the sensing element; a detection assembly configured to receive light from the sensing element; an opaque cover layer disposed over a side of the sensing element; and a battery in communication with the excitation assembly, wherein all components of the chemical sensor are implanted within the patient; transmitting data regarding the physiological concentration of the ion to an implanted pulse generator; measuring temperature with an implanted temperature sensor; calculating a compensated physiological concentration measurement of the ion using the measured temperature and the transmitted data regarding the physiological concentration of the ion; storing the compensated physiological concentration measurement of the ion with an associated time stamp in a memory of the implanted pulse generator; and delivering cardiac arrhythmia therapy from the implanted pulse generator to the patient based in part on the compensated physiological concentration of the ion. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method for controlling delivery of an active agent into a human body, the method comprising:
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measuring a physiological concentration of one or more analytes with chronically implanted system comprising a pulse generator and a chemical sensor, the chemical sensor comprising a sensing element comprising a potassium ion selective complexing moiety, the potassium ion selective complexing moiety selected from the group comprising cryptands, crown ethers, bis-crown ethers, calixarenes, noncyclic amides, and hemispherands; an excitation assembly configured to illuminate the sensing element; a detection assembly configured to receive light from the sensing element; an opaque cover layer disposed over a side of the sensing element; and a battery in communication with the excitation assembly, wherein all components of the chemical sensor are implanted within the patient; measuring temperature with an implanted temperature sensor; calculating a compensated physiological concentration measurement of the one or more analytes using the measured temperature and data from the detection assembly; storing the compensated physiological concentration measurement of the ion with an associated time stamp in a memory of the chronically implanted system; and varying delivery of the substance at least in part as a function of the compensated physiological concentration of the one or more analytes. - View Dependent Claims (10, 11)
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Specification