Retinal prosthesis with efficient processing circuits

• US 8,571,669 B2
• Filed: 02/24/2011
• Issued: 10/29/2013
• Est. Priority Date: 02/24/2011
• Status: Active Grant

• Current Assignee: Nano-Retina Inc.
• Original Assignee: Nano-Retina Inc.
• Inventors: Liran, Tuvia, Gefen, Ra'anan
• Primary Examiner(s): Koharski, Christopher D
• Assistant Examiner(s): VOORHEES, CATHERINE M
• Application Number:
  US13/034,516
• Publication Number:
  US 20120221103A1
• Time in Patent Office: 978 Days
• Field of Search: 607 53- 54, 607/116, 600/558
• US Class Current: 607/53
• CPC Class Codes: A61F 2/14 Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
• CPC Class Codes: A61N 1/36046 of the eye

Abstract

A medical device includes an array of electrodes, configured for implantation in contact with tissue in an eye of a living subject. Driver circuitry is configured to drive the electrodes in an alternating pattern, such that different groups of the electrodes are driven to stimulate the tissue during different, predetermined respective time periods. A power sensor, may be coupled to deactivate a first group of the electrodes when the available electrical power drops below a predetermined threshold, while a second group of the electrodes remains active. Other embodiments are also described.

Claims

1. A medical device, comprising:

a first array of electrodes, configured for implantation in contact with tissue in an eye of a living subject;

a second array of light-sensing elements, which are configured to output respective signals and a representation of a mean level of the signals, in response to light that is incident on the elements; and

a third array of conversion circuits, coupled to receive from the second array the signals from the light-sensing elements and the representation of the mean level of the signals, and configured to generate pulses to drive the electrodes at respective frequencies determined responsively to differences between the received signals and the representation of the mean level.

2. The device according to claim 1, wherein the conversion circuits are configured to generate an overshoot in the respective frequencies in response to a change in an intensity of the incident light on a given light-sensing element.

3. The device according to claim 1, wherein the conversion circuits comprise memory elements for returning the electrodes to a common level following the pulses.

4. The device according to claim 1, and comprising a common voltage reconstruction circuit, which is configured to receive inputs corresponding to the respective signals output by the light-sensing elements and to output the representation of the mean level to the conversion circuits.

5. The device according to claim 1, and comprising a power source coupled to supply electrical power to the driver circuitry, and a power sensor, which is configured to monitor a voltage output by the power supply and to deactivate a first group of the electrodes when the voltage drops below a predetermined threshold, while a second group of the electrodes remains active.

6. The device according to claim 1, wherein the representation of the mean level comprises a function of a mean value of the signals.

7. The device according to claim 6, wherein the function is selected from a group of functions consisting of a multiple of the mean value and a time-filtered mean value.

8. A medical device, comprising:

a first array of electrodes, configured for implantation in contact with tissue in an eye of a living subject;

a second array of light-sensing elements, which are configured to output respective signals in response to light that is incident on the elements; and

a third array of conversion circuits, coupled to receive the signals from the light-sensing elements, and configured to generate pulses to drive the electrodes at respective frequencies determined responsively to the received signals, the driving by the third array of conversion circuits including providing an overshoot in the respective frequencies in response to a change in an intensity of the incident light on a given light-sensing element.

9. The device according to claim 8, wherein the third array of conversion circuits is configured to drive the electrodes at the respective frequencies, and to configure the overshoot to include a transient increase in a frequency applied to a given electrode in response to an increase in the intensity incident on the given light-sensing element.

10. The device according to claim 8, wherein the conversion circuits comprise a low-pass filter for generating the overshoot.

11. The device according to claim 10, wherein the low-pass filter comprises a series of capacitive elements that are switched in sequence to generate a low-pass response.

12. The device according to claim 8, wherein the conversion circuits comprises memory elements for returning the electrodes to a common level following the pulses.

13. The device according to claim 8, and comprising a power source coupled to supply electrical power to the driver circuitry, and a power sensor, which is configured to monitor a voltage output by the power supply and to deactivate a first group of the electrodes when the voltage drops below a predetermined threshold, while a second group of the electrodes remains active.

14. A method for neural stimulation using a medical device comprising:

a first array of electrodes, configured for implantation in contact with tissue in an eye of a living subject;

a second array of light-sensing elements, which are configured to output respective signals and a representation of a mean level of the signals, in response to light that is incident on the elements; and

a third array of conversion circuits, coupled to receive from the second array the signals from the light-sensing elements and the representation of the mean level of the signals, and to generate pulses to drive the electrodes at respective frequencies determined responsively to differences between the received signals and the representation of the mean level, the method comprising the steps of;

providing the first array of electrodes for implantation in contact with the tissue in the eye of the living subject;

providing the second array of light-sensing elements to output the respective signals in response to the light that is incident on the elements; and

generating the pulses to drive the electrodes at the respective frequencies determined responsively to the differences between the signals output by the light-sensing elements and the representation of the mean level of the signals.

15. The method according to claim 14, wherein generating the pulses comprises generating an overshoot in the respective frequencies in response to a change in an intensity of the incident light on a given light-sensing element.

16. The method according to claim 14, and comprising coupling memory elements to return the electrodes to a common level following the pulses.

17. The method according to claim 14, wherein generating the pulses comprises deactivating a first group of the electrodes when a level of electrical power supplied for driving the electrodes drops below a predetermined threshold, while continuing to provide the pulses to a second group of the electrodes.

18. The method according to claim 14, wherein the representation of the mean level comprises a function of a mean value of the signals.

19. The method according to claim 18, wherein the function is selected from a group of functions consisting of a multiple of the mean value and a time-filtered mean value.

20. A method for neural stimulation using a medical device comprising:

a first array of electrodes, configured for implantation in contact with tissue in an eye of a living subject;

a second array of light-sensing elements, which are configured to output respective signals in response to light that is incident on the elements; and

a third array of conversion circuits, coupled to receive the signals from the light-sensing elements, and to generate pulses to drive the electrodes at respective frequencies determined responsively to the received signals, the driving by the third array of conversion circuits including providing an overshoot in the respective frequencies in response to a change in an intensity of the incident light on a given light-sensing element, the method comprising the steps of;

providing the first array of electrodes for implantation in contact with the tissue in the eye of the living subject;

providing the second array of light-sensing elements to output the respective signals in response to the light that is incident on the elements; and

generating pulses to drive the electrodes at the respective frequencies determined responsively to the signals, including the overshoot in the frequencies in response to the change in the intensity of the incident light on the given light-sensing element.

21. The method according to claim 20, wherein the overshoot comprises a transient increase in a frequency applied to a given electrode in response to an increase in the intensity incident on the given light-sensing element and a transient decrease in the frequency applied to the given electrode in response to a decrease in the intensity.

22. The method according to claim 21, wherein generating the pulses comprises applying a low-pass filter to generate the overshoot.

23. The method according to claim 22, wherein applying the low-pass filter comprises switching a series of capacitive elements in sequence to generate a low-pass response.

24. The method according to claim 21, and comprising coupling memory elements to return the electrodes to a common level following the pulses.

25. The method according to claim 21, wherein generating the pulses comprises deactivating a first group of the electrodes when a level of electrical power supplied for driving the electrodes drops below a predetermined threshold, while continuing to provide the pulses to a second group of the electrodes.