Packaging and delivery of pharmaceuticals and drugs

• US 8,573,202 B2
• Filed: 08/17/2010
• Issued: 11/05/2013
• Est. Priority Date: 06/28/2000
• Status: Expired due to Term

• Current Assignee: MicroDose Therapeutx, Inc. (Teva Pharmaceutical Industries Limited)
• Original Assignee: MicroDose Therapeutx, Inc. (Teva Pharmaceutical Industries Limited)
• Inventors: Gumaste, Anand V.
• Primary Examiner(s): Bianco, Patricia
• Assistant Examiner(s): PATEL, NIHIR B
• Application Number:
  US12/858,366
• Publication Number:
  US 20110030679A1
• Time in Patent Office: 1,176 Days
• Field of Search: 128/203.12, 128/203.15, 128/203.16, 128/203.21, 128/200.11, 128/200.12, 128/200.23, 206530-532, 206/538, 206/539
• US Class Current: 128/203.12
• CPC Class Codes: A61M 15/0045 using multiple prepacked dosages on a same carrier, e.g. blisters
• CPC Class Codes: A61M 15/0051 the dosages being arranged on a tape, e.g. strips
• CPC Class Codes: A61M 15/0085 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2205/0233 Conductive materials, e.g. antistatic coatings for spark prevention
• CPC Class Codes: B65D 75/323 and forming several compartments
• CPC Class Codes: B65D 75/327 and forming several compartments
• CPC Class Codes: B65D 75/34 and having several recesses to accommodate a series of articles or quantities of material not used

Abstract

A blister pack for use with inhalation therapy inhalers comprises an elongate bottom element having an overlying top element defining a plurality of spaced top crowned areas containing powder or liquid medications or drugs.

Claims

1. A blister pack for use with inhalation therapy inhalers equipped with a vibratory de-aggregator, comprising a first element comprising an elongate tape having spaced areas for interfacing and coupling with an inhaler vibratory de-aggregator, and a frangible second element overlying the first element and defining a plurality of spaced top crowned areas located over said first element spaced areas, and containing powder or liquid material, wherein the contents of the blister are forcible ejected from the blister through a plurality of holes in the top crown areas of the frangible second element when the spaced areas are interfaced coupled with a vibratory de-aggregator.

2. The blister pack according to claim 1, wherein said top crowned areas are shaped as inverted cones.

3. The blister pack according to claim 1, wherein said top crowned areas are shaped as rounded domes.

4. The blister pack according to claim 1, wherein the first element includes a depression opposite the top crowned areas.

5. The blister pack according to claim 4, wherein the depression is shaped as an inverted cone.

6. The blister pack according to claim 4, wherein the depression is shaped as an inverted pill box.

7. The blister pack according to claim 1, wherein said material comprises a medication.

8. The blister pack according to claim 1, wherein said material comprises a vitamin.

9. The blister pack according to claim 1, wherein said material comprises a hormone.

10. The blister pack according to claim 1, wherein said material comprises a steroid.

11. The blister pack according to claim 1, wherein said material comprises a bioactive material.

12. The blister pack according to claim 1, wherein a size and number of holes together with volume formed by the blister pack are optimized for de-aggregation and aerosolization of material in the blister pack.

13. The blister pack according to claim 1, wherein a height and shape of the blister pack is optimized for de-aggregation and aerosolization of material in the blister pack.

14. The blister pack according to claim 1, wherein an interface to a vibrator is optimized for optimum coupling of the energy into the blister pack for de-aggregation and aerosolization of material in the blister pack.

15. The blister pack according to claim 1, wherein said holes act as filters or screens to prevent ejection from the blister of particles of said powder or liquid material of a size greater than a predetermined size.

16. The blister pack according to claim 1, wherein said holes are formed by puncturing said frangible second element.

17. The blister pack according to claim 1, wherein said elongate tape is flexible.