Vital sign monitor for cufflessly measuring blood pressure using a pulse transit time corrected for vascular index

• US 8,574,161 B2
• Filed: 06/12/2008
• Issued: 11/05/2013
• Est. Priority Date: 06/12/2007
• Status: Active Grant

• Current Assignee: Sotera Wireless Incorporated
• Original Assignee: Sotera Wireless Incorporated
• Inventors: Banet, Matthew J., Zhou, Zhou, Dhillon, Marshal Singh, Kopotic, Robert J., Terry, Andrew Stanley, Visser, Henk II
• Primary Examiner(s): ANGELL, JON E
• Application Number:
  US12/138,199
• Publication Number:
  US 20090018422A1
• Time in Patent Office: 1,972 Days
• Field of Search: 600/493
• US Class Current: 600/493
• CPC Class Codes: A61B 2562/08 Sensors provided with means for identification, e.g. barcodes or memory chips
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02125 of pulse wave propagation time
• CPC Class Codes: A61B 5/0285 Measuring or recording phase velocity of blood waves
• CPC Class Codes: A61B 5/352 Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives
• CPC Class Codes: A61B 5/7257 using Fourier transforms
• CPC Class Codes: A61B 5/7475 User input or interface means, e.g. keyboard, pointing device, joystick

Abstract

A method and apparatus for measuring a patient'"'"'s blood pressure featuring the following steps: 1) measuring a time-dependent optical waveform with an optical sensor; 2) measuring a time-dependent electrical signal with an electrical sensor; 3) estimating the patient'"'"'s arterial properties using the optical waveform; 4) determining a pulse transit time (PTT) from the time-dependent electrical signal and the time-dependent optical waveform; and 5) calculating a blood pressure value using a mathematical model that includes the PTT and the patient'"'"'s arterial properties.

Claims

1. A system for monitoring a patient'"'"'s blood pressure parameter, the system comprising:

an optical sensor configured to attach to the patient and generate a time-dependent optical waveform representing a flow of blood within the patient;

an electrode system configured to attach to the patient and generate a time-dependent electrical waveform representing activity of the patient'"'"'s heart;

a calibration system configured to attach to a portion of the patient'"'"'s body and apply a pressure; and

a processing component programmed to;

i) determine a first set of pulse transit times, wherein each transit time within the set is a measure of a separation in time of a first feature of the time-dependent electrical waveform and a second feature of the time-dependent optical waveform, the first set of pulse transit times measured while the calibration system applies the pressure to the portion of the patient'"'"'s body;

ii) analyze the first set of pulse transit times with a mathematical model that processes a pressure-induced change in transit time to determine a calibration representing properties of the patient'"'"'s blood circulatory system; and

iii) calculate the blood pressure parameter from a second pulse transit time and the calibration, the second pulse transit time measured while the calibration system does not apply pressure to the portion of the patient'"'"'s body.

2. The system of claim 1, wherein the calibration represents the patient'"'"'s vascular index.

3. The system of claim 2, wherein the calibration is linearly proportional to the vascular index.

4. The system of claim 2, wherein the processing component is programmed to analyze the time-dependent optical waveform by:

bandpass filtering the time-dependent optical waveform to generate a filtered waveform;

computing a derivative of the filtered waveform to generate a derivative waveform; and

computing the calibration from characteristics of a waveform derived from the derivative waveform.

5. The system of claim 4, wherein the processing component is further programmed to analyze the time-dependent optical waveform by filtering the derivative waveform to generate the derived waveform.

6. The system of claim 4, wherein the derivative that is used to generate the derivative waveform is the second derivative.

7. The system of claim 1, wherein the first feature of the time-dependent electrical waveform is a QRS complex and the second feature of the time-dependent optical waveform corresponds to an onset of a pressure pulse.

15. The system of claim 1, wherein the mathematical model is a linear model.

16. The system of claim 15, wherein the linear model relates a pressure-dependent change in estimated mean arterial pressure (Δ

MAP(P_applied)) while pressure is applied by the calibration system to;

i) the pressure applied (P_applied);

applied);

ii) a diastolic blood pressure measured by the calibration system (DIA); and

iii) a mean arterial pressure measured by the calibration system (MAP).

17. The system of claim 16, wherein the linear model estimates the effective pressure-dependent mean arterial pressure in the portion of the patient'"'"'s body (MAP*(P)) while pressure is applied.

18. The system of claim 17, wherein the linear model comprises the equations:

Δ

MAP(P)˜

(P_applied−

DIA) and MAP*(P)=MAP−

Δ

MAP(P).

19. The system of claim 18, wherein the mathematical model estimates a mathematical relationship between pulse transit time and MAP*(P).

20. The system of claim 19, wherein the calibration comprises the mathematical relationship between pulse transit time and MAP*(P).

21. The system of claim 20, wherein a unique transit time is determined for each of the patient'"'"'s heartbeats generated while pressure is applied by the calibration system.

8. A method of monitoring a patient'"'"'s blood pressure parameter, the method comprising:

detecting a time-dependent optical waveform from a flow of blood within the patient;

detecting a time-dependent electrical waveform representing activity of the patient'"'"'s heart;

applying a pressure to a portion of the patient'"'"'s body while detecting the optical waveform and the electrical waveform;

analyzing the time-dependent optical waveform and the time-dependent electrical waveform while pressure is applied to a portion of the patient'"'"'s body to determine a set of pulse transit times featuring values that change with the amount of applied pressure, wherein each pulse transit time within the set is a measure of a separation in time of a first feature of the time-dependent electrical waveform and a second feature of the time-dependent optical waveform, the set of pulse transit times representing properties of the patient'"'"'s blood circulatory system;

processing the pressure-dependent change in pulse transit times within the set of pulse transit times with a mathematical model to determine a calibration;

measuring a second pulse transit time for the patient while pressure is not applied to the portion of the patient'"'"'s body; and

determining the blood pressure parameter from the second pulse transit time and the calibration.

9. The method of claim 8, wherein analyzing the time-dependent optical waveform involves:

bandpass filtering the time-dependent optical waveform to generate a filtered waveform;

computing a derivative of the filtered waveform to generate a derivative waveform; and

computing the calibration from characteristics of a waveform derived from the derivative waveform.

10. The method of claim 9, further comprising filtering the derivative waveform to generate the derived waveform.

11. The method of claim 9, wherein the derivative that is used to generate the derivative waveform is the second derivative.

12. The method of claim 9, wherein the first feature of the time-dependent electrical waveform is a QRS complex and the second feature of the time-dependent optical waveform corresponds to an onset of a pressure pulse.

13. A system for monitoring a patient'"'"'s blood pressure parameter, the system comprising:

an optical sensor configured to attach to the patient and generate a time-dependent optical waveform representing a flow of blood within the patient;

an electrode system configured to attach to the patient and generate a time-dependent electrical waveform representing activity of the patient'"'"'s heart;

a calibration system configured to attach to a portion of the patient and apply a pressure; and

a processing component programmed to;

i) determine a set of pulse transit times while the calibration system applies pressure to the portion of the patient, with each pulse transit time within the set representing a measure of a separation in time of a first feature of the time-dependent electrical waveform and a second feature of the time-dependent optical waveform;

ii) analyze the pressure-dependent change in values of pulse transit times within the set of pulse transit times with a mathematical model to determine a vascular index representing properties of the patient'"'"'s blood circulatory system; and

iii) use the vascular index and a pulse transit time measured when pressure is not applied by the calibration system to determine a value of a blood pressure parameter for the patient.

14. A method of monitoring a patient'"'"'s blood pressure parameter, the method comprising:

generating a time-dependent optical waveform from a flow of blood within the patient;

detecting a time-dependent electrical waveform representing activity of the patient'"'"'s heart;

applying a pressure to a portion of the patient'"'"'s body;

analyzing the time-dependent optical waveform and the time-dependent electrical waveform while pressure is applied to a portion of the patient'"'"'s body to determine a set of pulse transit times, with each transit time representing a measure of a separation in time of a first feature of the electrical waveform and a second feature of the optical waveform, and a pressure-dependent change in the values of transit times indicating a vascular index representing properties of the patient'"'"'s blood circulatory system;

processing the pressure-dependent change in the values of transit times within the set of pulse transit times with a mathematical model to determine a calibration;

determining a pulse transit time for the patient when pressure is not applied to a portion of the patient'"'"'s body; and

using the calibration and a measured pulse transit time for the patient to determine a value of the blood pressure parameter for the patient.

22. A system for monitoring a patient'"'"'s blood pressure parameter, comprising body-worn sensors for measuring optical and electrical waveforms, a pressure-applying calibration system, a first processing system for determining a transit time from the optical and electrical waveforms, a second processing system for calculating a calibration from a pressure-induced change in transit time caused by the calibration system, and a third processing system for calculating the blood pressure parameters from the calibration and a transit time.

23. A system for monitoring a patient'"'"'s blood pressure parameter, the system comprising:

an optical sensor configured to attach to the patient and generate a time-dependent optical waveform representing a flow of blood within the patient;

an electrode system configured to attach to the patient and generate a time-dependent electrical waveform representing activity of the patient'"'"'s heart; and

a processing component programmed to;

i) determine a first pulse transit time, which is a measure of a separation in time of a first feature of the time-dependent electrical waveform and a second feature of the time-dependent optical waveform;

ii) analyze the optical waveform to determine its second mathematical derivative;

iii) determine a set of fiducial points from the second mathematical derivative;

iv) process the set of fiducial points with a mathematical model to estimate a vascular index representing properties of the patient'"'"'s blood circulatory system; and

v) determine an estimate of the blood pressure parameter from a measured second pulse transit time for the patient and the vascular index measured from the optical waveform used to calculate the second pulse transit time.