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Sub-mucosal agent delivery method for the eye

  • US 8,574,217 B2
  • Filed: 02/10/2011
  • Issued: 11/05/2013
  • Est. Priority Date: 04/08/2010
  • Status: Active Grant
First Claim
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1. A method for administering a pharmacological agent formulation to a sub-mucosal compartment of an organ, comprising the steps of (i) providing an agent delivery apparatus containing the pharmacological agent formulation in an internal formulation chamber, said agent delivery apparatus including a needleless delivery member, said delivery member including a deformable positioning hood that is adapted to substantially conform to the surface of an organ and position said delivery member on said organ when in an engagement position thereon, needleless injector means that is in communication with said internal formulation chamber, and force generating means that is adapted to generate sufficient force to expel the pharmacological agent formulation from said agent delivery apparatus and into an organ, (ii) positioning said agent delivery apparatus on a surface of a first organ, and (iii) activating said agent delivery apparatus, whereby the pharmacological agent formulation is expelled from said agent delivery apparatus by said force generating means and delivered to the surface of said first organ with a delivery pressure in the range of approximately 100-1000 psi and, whereby a first volume of the pharmacological agent formulation is administered to a sub-mucosal compartment of said first organ, wherein said first organ comprises the eye.

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